Brian Shy



Brian Shy, MD, PhD is a visiting investigator at Gladstone Institutes. He is also an assistant professor of laboratory medicine at UC San Francisco (UCSF) and the director of the UCSF human islet and cellular transplantation GMP Facility.

Shy’s laboratory focus is on the development, manufacturing, and delivery of novel cell and gene therapies. His group employs genome and epigenome engineering tools to enhance the safety and potency of cellular therapies, improve manufacturing methods, and develop new products targeting inherited immune disorders, infectious disease, and cancer. He has developed several methods to enable fully non-viral CRISPR engineering and is helping to drive these approaches towards clinical trials.

Shy received his MD and PhD at the University of Illinois, and completed residency and fellowship training in clinical pathology and transfusion medicine at UCSF. He completed postdoctoral training in the laboratory of Alex Marson, where he developed approaches to improve gene editing in primary human T cells. Shy has been a member of the Gladstone-UCSF Institute of Genomic Immunology since 2022.