Katerina Akassoglou and her team have discovered new mechanisms that control the communication between the brain, the immune system, and the vascular system, and designed novel therapies for neurological diseases. Akassoglou’s lab pioneered studies showing that when the blood-brain barrier is disrupted, the blood-clotting factor fibrinogen can leak into the brain, where it induces neurodegeneration. Their findings indicate that fibrinogen leakage could contribute to a wide range of neurological conditions, including multiple sclerosis, Alzheimer’s disease, traumatic brain injury, and stroke.

Disease Areas

Multiple Sclerosis
Alzheimer’s Disease
Traumatic Brain Injury
Epilepsy
Autoimmune Diseases
Spinal Cord Injury
Depression

Areas of Expertise

Blood-brain Barrier
Neuroimmunology
Coagulation
Disease Models
In Vivo Imaging
Two-photon Microscopy
Working in the Akassoglou lab

Lab Focus

Identifying the functional role of blood-brain barrier disruption in inflammation, neurodegeneration, and repair in neurological diseases.
Discovery of new mechanisms that control brain-vascular-immune communication
Developing first-in-class therapies for neurodegeneration and neurorepair
Developing new imaging methods for early detection of neuroinflammation and neurovascular alterations in neurological diseases.

Research Impact

Work from Akassoglou’s lab has led to a new way of thinking about neurological diseases by proposing a fundamental mechanism through which cerebrovascular dysfunction impairs the brain and spinal cord. Specifically, they demonstrated that the neurovascular interface is fundamentally changed in neurological disease, resulting in increased blood-brain barrier permeability that promotes toxic brain inflammation. They identified the blood clotting factor fibrinogen as a common driver for neuroinflammation and neurodegeneration and inhibitor of neurorepair. They developed the first immunotherapy that blocks the deleterious functions of fibrin and protects from neuroinflammation and neurodegeneration in animal models of multiple sclerosis and Alzheimer’s disease. Therefore, the team’s research has broad impact on the understanding of and ability to treat multiple neurological diseases, including multiple sclerosis, stroke, epilepsy, traumatic brain injury, and spinal cord injury.

Akassoglou’s team continues to investigate the mechanisms at the neurovascular interface that promote neuroinflammation, neurodegeneration, and cognitive decline. They hope to use their discoveries to develop innovative treatments, and fluid and imaging biomarkers for devastating neurological diseases.

 

Professional Titles

Senior Investigator, Gladstone Institutes

Director, Gladstone-UCSF Center for Neurovascular Brain Immunology

Professor of Neurology, UC San Francisco

Bio

Katerina Akassoglou, PhD, is a senior investigator and director of the Gladstone UCSF Center for Neurovascular Brain Immunology. She is also a professor of neurology at UC San Francisco.

A native of Greece, Akassoglou earned both a bachelor's of science in biology and a PhD in neuroimmunology at the University of Athens, Greece with training in neuropathology by Hans Lassmann at the University of Vienna. Akassoglou completed her postdoctoral work at the State University of New York at Stony Brook, Rockefeller University with Sid Strickland, and at New York University with Moses Chao. Prior to joining Gladstone in 2008, she was an assistant professor of Pharmacology at UC San Diego. She has led multiple international collaborations between academia and pharma, and has given over 200 lectures nationally and internationally. She is active in several scientific organizations, editorial boards, and funding agencies, has published over 100 papers, and is a named inventor on 20 patents and patent applications. She is the scientific founder and Board Director of the VC-backed university spin-out Therini Bio. She has received several awards including the Presidential Early Career Award for Scientists and Engineers by The White House, the highest honor bestowed by the US government on outstanding scientists and engineers beginning their independent careers, the John J. Abel Award, the R35 Research Program Award by NINDS, and the Barancik Prize for Innovation in MS research. Dr. Akassoglou is a Fellow of the American Neurological Association (ANA), elected Fellow of the National Academy of Inventors (NAI) and Lifetime Fellow of the American Association for the Advancement of Science (AAAS). She was named by the San Francisco Business Times among the 2021 Most Influential Women in Bay Area Business.

How Did You Get Your Start in Science?

“I was inspired by my biology high school teacher. She helped me get a summer internship in an immunology lab and I never looked back.”

Katerina Akassoglou, PhD

Honors and Awards

2022 Lifetime Fellow, American Association for the Advancement of Sciences (AAAS)

2022 ASPET-JPS Keynote Lecture at the 95th Japanese Pharmacological Society Meeting

2021 Fellow, National Academy of Inventors

2021 Rita-Levi Montalcini Neurobiology Keynote Lecture – International Society for Neuroimmunology

2021 Most Influential Women in Bay Area Business, San Francisco Business Times

2019 Barancik Prize for Innovation in Multiple Sclerosis Research, National Multiple Sclerosis Society

2019 Greek Top Women Award

2018 Fellow, American Neurological Association

2016 R35 NINDS Research Program Award

2015 The Marilyn Hilton Award for Innovation in MS Research, Conrad N. Hilton Foundation

2015 Secretary/Treasurer, Molecular Pharmacology Division, American Society for Pharmacology and Experimental Therapeutics

2009 Vilcek Prize for Creative Promise in Biomedical Research (Finalist), Vilcek Foundation

2009 Exceptional Unconventional Research Enabling Knowledge Acceleration Award EUREKA, National Institutes of Health

2008 John J. Abel Award in Pharmacology, American Society for Pharmacology and Experimental Therapeutics

2007 Presidential Early Career Award for Scientists and Engineers, The White House

2007 The Dana Award in Brain and Immunoimaging

2006 Young Investigator Award, International Fibrinogen Society

2002 Young Investigator Award, International Society for Neurochemistry

2000 Young Investigator Award, International Society for Fibrinolysis and Proteolysis

1999 Fellow, Human Frontiers Science Program

1998 Women in Neuroimmunology Award, International Society of Neuroimmunology

1998 European League Against Rheumatism

Publications

More Publications

Contact

Katerina Akassoglou
Email
415.734.2512


Lab Members

Pilar Alzamora
Senior Research Associate
Belinda Cabriga
Research Scientist
Karuna Dixit, PhD
Postdoctoral Scholar
Brandon Nicholas Guo
Student Intern
Eilidh MacDonald
Student Intern
Andrew Mendiola, PhD
Scientist
Mark Petersen, MD
Visiting Scientist
Mark Petersen, MD
Visiting Scientist
Jae Ryu, PhD
Scientific Program Leader II
Elif Sozmen, MD, PhD
Visiting Scientist
Reshmi Tognatta, PhD
Scientist
Olivia Weaver
Visiting Researcher
Zhaoqi Yan, PhD
Postdoctoral Scholar