Convergence Seminar
Tuesday, March 5, 2024

Joshua Rosenthal, PhD

Senior Scientist, Bell Center, Marine Biological Laboratory, Woods Hole

Genetic information's transient residence in mRNA provides a prime opportunity for modification. Changes in DNA are permanent and perilous; those in RNA go away, making them safer. There are a variety of systems for altering RNA in cells. Alternative splicing, of course, is a well-studied example. Joshua Rosenthal's lab focuses on RNA editing through adenosine deamination, a system for introducing point mutations within RNA. All multicellular metazoans edit their mRNA, but cephalopods take it to a new level, particularly in their nervous system.

In his talk he will discuss how cephalopods use RNA editing, the messages that they target, where editing takes place within neurons, and how it can respond to environmental cues. Finally, based on new data using the first genetically tractable cephalopod model and CRISPR, he will show how a novel RNA editing enzyme isoform is driving the high-level cephalopod recoding.

Co-Hosted by Gladstone and Quantitative Biosciences Institute UCSF

Details

Dates
March 5, 2024
Time
2:00-3:00pm PST
Location
Mahley Auditorium
Audience
Gladstone and UCSF
Contact(s)





The Convergence Seminar is organized by Gladstone’s Institute for Data Science and Biotechnology. This seminar series brings together scientists from varying disciplines to solve complex scientific questions and accelerate the path to cures.

Diversity, Equity, and Inclusion

At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.

We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.