Center for Cell Circuitry Seminar
Friday, February 4, 2022

John Coffin, PhD

Professor of Molecular Biology and Microbiology
Tufts University School of Medicine, Boston, Massachusetts

John Coffin will discuss the application of integration site analysis to elucidate the nature and effect of the forces that act on HIV-infected cells before and during suppressive antiretroviral therapy, including the effects of the following factors on shaping proviral patterns:

  • Gene expression at the time of integration
  • Selection against cells with proviruses in expressed genes
  • Selection for cells with proviruses in a few specific cancer genes
  • Role of provirus-driven modification of gene expression in clonal expansion

Together these factors give rise to a robust bed of proviral embers, readily and almost inevitably rekindled to restore active infection once therapy is terminated.


February 4, 2022
10:00-11:00am PST

The Center for Cell Circuitry Seminar connects investigators across disciplines to develop single-cell tools to map how cellular components connect into circuits. The center aims to develop new single-cell approaches that overcome limitations inherent in traditional techniques that analyze bulk populations of cells, thereby obscuring individual cell behavior.

Diversity, Equity, and Inclusion

At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.

We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.