Center for Cell Circuitry Seminar
John Coffin, PhD
John Coffin will discuss the application of integration site analysis to elucidate the nature and effect of the forces that act on HIV-infected cells before and during suppressive antiretroviral therapy, including the effects of the following factors on shaping proviral patterns:
- Gene expression at the time of integration
- Selection against cells with proviruses in expressed genes
- Selection for cells with proviruses in a few specific cancer genes
- Role of provirus-driven modification of gene expression in clonal expansion
Together these factors give rise to a robust bed of proviral embers, readily and almost inevitably rekindled to restore active infection once therapy is terminated.
Details
Dates
February 4, 2022Time
10:00-11:00am PSTLocation
OnlineThe Center for Cell Circuitry Seminar connects investigators across disciplines to develop single-cell tools to map how cellular components connect into circuits. The center aims to develop new single-cell approaches that overcome limitations inherent in traditional techniques that analyze bulk populations of cells, thereby obscuring individual cell behavior.
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