Convergence Seminar
Monday, May 8, 2023

Veer Keizer, PhD

National Institutes of Health, National Cancer Institute, Center for Cancer Research

Have you ever wondered what chromatin is like in the nucleus of a living cell? In this talk, Keizer will discuss a novel tool to actively manipulate chromatin in live cells using magnetism. By physically moving chromatin through the nuclear space, Her team gained a better understanding of key chromatin characteristics and chromatin organization. The observed behavior could be recapitulated with a Rouse model that includes only a weak obstructive effect of the surrounding chromatin and nucleoplastic material. This challenges the view that interphase chromatin is a gel-like material and has important implications for nuclear functions such as transcription and DNA damage repair.

About the Speaker

Currently, Veer Keizer is a visiting fellow in the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute (NCI/NIH). She obtained her PhD from Leiden University, where she studied transcription factor binding dynamics using live cell single-molecule imaging techniques. Between 2017 and 2020, she carried out postdoctoral work at Institut Curie in Paris. There, she developed a tool to manipulate chromatin in live cells using magnetism and gained insight into the mechanical properties of chromatin. As a member of Dan Larson’s Systems Biology of Gene Expression Group, she is leveraging imaging techniques and other tools at the interface between physics and biology to gain insight into the direct link between chromatin interactions and transcription.

Details

Dates
May 8, 2023
Time
11:00am-12:00pm PDT
Location
Mahley Auditorium & Online
Audience
Gladstone and UCSF
Contact(s)





The Convergence Seminar is organized by Gladstone’s Institute for Data Science and Biotechnology. This seminar series brings together scientists from varying disciplines to solve complex scientific questions and accelerate the path to cures.

Diversity, Equity, and Inclusion

At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.

We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.