Emma Chory, PhD
Evolution occurs when selective pressures from the environment shape inherited variation over time. Within the laboratory, evolution is commonly used to engineer proteins and RNA, but experimental constraints have limited our ability to reproducibly and reliably explore key factors such as population diversity, the timing of environmental changes, and chance. Emma Chory's lab developed a high-throughput system for the analytical exploration of molecular evolution using phage-based mutagenesis to evolve many distinct classes of biomolecules simultaneously. In this talk, she will describe the development of their open-source python:robot integration platform which enables them to adjust the stringency of selection in response to real-time evolving activity measurements and to dissect the historical, environmental, and random factors governing biomolecular evolution. Finally, she will talk about their many on-going and future projects which utilize this system to evolve previously intractable biomolecules to target the undruggable proteome.
Hosted by: Vijay Ramani, PhD
DatesJanuary 9, 2023
AudienceGladstone and UCSF
The Convergence Seminar is organized by Gladstone’s Institute for Data Science and Biotechnology. This seminar series brings together scientists from varying disciplines to solve complex scientific questions and accelerate the path to cures.
Diversity, Equity, and Inclusion
At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.
We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.