Gladstone-UCSF Institute of Genomic Immunology Seminar
John Tsang, PhD
John Tsang is a senior investigator in the NIH Intramural Research Program and leads a lab focusing on systems and quantitative immunology at the National Institute of Allergy and Infectious Diseases (NIAID). He also co-directs the Trans-NIH Center for Human Immunology and leads its research program in systems human immunology.
The Tsang Lab develops and applies systems biology approaches—combining computation, modeling, and experiments—to study the immune system at the organismal, cellular, and molecular levels. At the organismal level (particularly in humans), they utilize natural variation (disease and genetic variation) and interventions (particularly vaccination) to systemically perturb the immune system and comprehensively assess its status pre- and post-intervention using multiplexed technologies in human cohorts. The resulting multi-modal datasets are analyzed and modeled in an integrative manner to: 1) uncover biomarkers of immune responsiveness and health, 2) infer interactions among components of the immune system, and ultimately, 3) understand how immune responses are orchestrated quantitatively across scales—from molecules to cells to cell-to-cell interactions in space and time. They have also begun to generate and incorporate similar large-scale data from mouse models to develop a more complete (e.g., including dynamics and tissue statuses) understanding.
The lab has also been participating in a large, international NIAID-wide collaboration to investigate the innate and adaptive immune responses during acute COVID-19 infection and convalescence. Learn more about the systems immunology of COVID-19 project by joining us at this special seminar!
Details
Dates
March 15, 2022Time
10:00-11:00am PDTLocation
OnlineAudience
Gladstone and UCSFContact(s)
The Gladstone-UCSF Institute of Genomic Immunology Seminar Series showcases speakers at the intersection of genomic technology and immunology research with an aim to engineer the human immune system for therapeutic benefit. Speakers span technology development, synthetic biology, bioengineering, and the development and clinical application of immunotherapy. These talks are open to the Gladstone and UCSF communities.
Diversity, Equity, and Inclusion
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