Melanie Ott’s lab studies viruses that infect humans, and applies the lessons learned to new and emerging viruses. Founded at the peak of the AIDS epidemic, the lab has since broadened its scope from HIV to other viruses with global relevance such as hepatitis C virus, Zika virus, and SARS-CoV-2. The Ott Lab combines broad expertise—in virology, cell biology, biochemistry, systems biology, and chromatin biology—with a diverse and highly collaborative approach. They focus on human-host factors restricting or enabling viral infections, and build and study complex primary cell systems, such as organoids, to model physiological conditions closely. Ott’s team leads the HOPE Collaboratory, an NIH-funded multidisciplinary research consortium dedicated to eradicating HIV. The Ott lab also leads projects on respiratory virus infections in NIH-funded UCSF QCRG AViDD and HPMI programs.
Disease Areas
COVID-19/SARS-CoV-2
HIV/AIDS
Zika
Influenza
Hepatitis
Bunya
Areas of Expertise
Virology
Chromatin Biology
Organoids
Lipid Droplets
CRISPR Diagnostics
Reverse Genetics
Lab Focus
Developing a diagnostic platform that combines CRISPR-based biochemistry with smartphone optics for the rapid and quantitative detection of RNA viruses—including SARS-CoV-2 and HIV.
Utilizing human organoids derived from adult tissues, adult stem cells, or induced pluripotent stem cells to model infection of the lung, liver, intestine, brain, or airways.
Building a library of all the proteins encoded in the genomes of HIV, Zika, influenza, SARS-CoV-2, and others as a resource for cross-cutting virology research.
Adapting single-cell and bulk genomic, transcriptomic, and proteomic technology to analyze organoids and immune cells, and innovative chromatin tools to study latent HIV provirus.
Developing reverse genetics tools for SARS-CoV-2 (infectious clones, replicons, and virus-like particles) to study viral variants, the effect of mutations on viral fitness, and screen antiviral compounds rapidly.
Research Impact
The Ott Lab has uncovered a number of ways in which viruses harness the biology of human cells to their own benefit and to the detriment of their hosts.
These findings pave the way for the development of therapies that target the virus-host interface.
For instance, the lab demonstrated the importance of non-histone protein acetylation in HIV transcription and latency, ushering in the use of drugs that block acetylation as a potential step toward the eradication of HIV. They discovered a major pathway explaining hepatitis C virus’s dependence on lipid droplets inside liver cells, and identified nonsense-mediated RNA decay as a new host defense against RNA viruses that is inactivated by Zika virus.
Since the beginning of the COVID-19 pandemic, Ott’s lab and collaborators developed a testing platform that detect SARS-CoV-2 RNA without amplification, using CRISPR/Cas13a and a mobile phone. The platform could be deployed for rapid molecular testing at home or at a point-of-care facility.
They have used genome-wide CRISPR screens to identify host pathways enabling the replication of SARS-CoV-2 and of common cold coronaviruses as the basis for new pan-coronaviral therapeutic strategies.
They have also characterized Delta, Epsilon, and Omicron variants with pseudotyped viruses, virus-like particles and full-length molecular clones to identify mutations in S and N proteins that increase viral spread.
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Professional Titles
Director, Gladstone Institute of Virology
Senior Investigator, Gladstone Institutes
Senior Vice President, Gladstone Institutes
Professor, Department of Medicine, UC San Francisco
Director, Michael Hulton Center for HIV Cure Research
Bio
In Melanie Ott’s lab, the scientific goal is clear: We research the viruses of today to prepare for the viruses of tomorrow. Toward that end, she and her team are unraveling how viruses—including hepatitis C, HIV, SARS-CoV-2, and Zika—hijack human cells, and they are designing ways to thwart these pathogens.
A native of Germany, earned her medical degree in 1991 from the University of Frankfurt/Main. During her neurology residency in Frankfurt, she watched an overwhelming number of people with HIV die for lack of a treatment or cure. Seeking answers, Ott moved to the U.S. to study HIV in the laboratory and earned her PhD from the Elmezzi Graduate School of Molecular Medicine at Northwell Health. Following a five-year stint leading her own lab at the German Cancer Research Center, and working closely with virologist and Nobel laureate Harald zur Hausen, Ott returned to the U.S. in 2002 to join Gladstone Institutes.
Here, in addition to her laboratory investigations, Ott directs the global HOPE (HIV Obstruction by Programming Epigenetics) Collaboratory, which seeks to both silence and permanently remove HIV from the body. She also lends her scientific expertise to the council of the National Institute of Drug Abuse (NIDA) and to the FDA’s Cellular, Tissue, and Gene Therapies Advisory Committee. For InvisiShield Technologies Ltd, a company developing therapeutics to prevent respiratory infections, she chairs the scientific advisory board.
Always a proponent of opening laboratory doors to any student interested in science, Ott founded the PUMAS summer internship program at Gladstone, for which she has received much recognition.
What are you most excited about in your lab right now?
“I am truly excited about the incredible motivation and dedication of my lab, the sense that our work is making a difference in people’s lives and the speed with which we can now progress from viral genotype to disease phenotype. Our rapid reverse genetics technology allows us to safely study any viral variant, its replication capacity and ability to cause disease in less than 2 weeks, and is widely shared with our colleagues.”
Melanie Ott, MD, PhD
Honors and Awards
2020 Named one of the Most Influential Women in the Bay Area by "San Francisco Business Times"
2020 Inspire Award, "San Francisco Business Times"
2019 NIH Merit Award, National Institutes of Health
2018 UCSF AIDS Research Institute Award for Outstanding Teaching and Mentoring
2018 Elected fellow, American Academy of Microbiology
2017 Pantheon Award: Biotechnology Educator of the Year, California Life Sciences Association
2014 Avant-Garde Award, National Institutes of Health
2013 Elected member, Association of American Physicians
2008 Thomas N. Burbridge Award, UC San Francisco
2008 UCSF Chancellor’s Award for Public Service, UC San Francisco
2000 Young Researcher Award, European Conference on Experimental AIDS Research, Madrid, Spain
Publications
- Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.
Rosas-Lemus M, Minasov G, Brunzelle JS, Taha TY, Lemak S, Yin S, Shuvalova L, Rosecrans J, Khanna K, Seifert HS, Savchenko A, Stogios PJ, Ott M, Satchell KJF. Protein Sci. 2025 Mar; 34(3):e70050. - SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation.
Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. PLoS Pathog. 2024 Nov; 20(11):e1012741. - Intracellular lipid droplets are exploited by JunĂn virus in a nucleoprotein-dependent process.
Vazquez CA, Escudero-Pérez B, Hayashi JM, Leon KE, Moreira JP, Castañeda Cataña MA, Groseth A, Ott M, Oestereich L, Muñoz-Fontela C, Garcia CC, Cordo SM. J Cell Sci. 2024 Oct 01; 137(19). - Silencing the transcriptionally active HIV reservoir to improve treatment outcomes.
Prigann J, Tavora R, Furler O'Brien RL, Schulze-Gahmen U, Boehm D, Roan NR, Nixon DF, Ndhlovu LC, Valente S, Ott M. Nat Microbiol. 2024 Oct; 9(10):2470-2472. - Understanding emerging and re-emerging viruses to facilitate pandemic preparedness.
Zapatero-BelinchĂłn FJ, Kumar P, Ott M, Schwartz O, Sigal A. Nat Microbiol. 2024 Sep; 9(9):2208-2211. - De novo-designed minibinders expand the synthetic biology sensing repertoire.
Weinberg ZY, Soliman SS, Kim MS, Shah DH, Chen IP, Ott M, Lim WA, El-Samad H. bioRxiv. 2024 Aug 29. - The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.
Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Zapatero-BelinchĂłn FJ, McCavittMalvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Richards AL, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS. bioRxiv. 2024 Aug 29. - Fibrin drives thromboinflammation and neuropathology in COVID-19.
Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K. Nature. 2024 Sep; 633(8031):905-913. - Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.
Li L, Matsui Y, Prahl MK, Cassidy AG, Golan Y, Jigmeddagva U, Ozarslan N, Lin CY, Buarpung S, Gonzalez VJ, Chidboy MA, Basilio E, Lynch KL, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens J, Rincon M, Myatt L, Taha TY, Montano M, Ott M, Greene WC, Gaw SL. NPJ Vaccines. 2024 Aug 27; 9(1):156. - Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains.
Rosas-Lemus M, Minasov G, Brunzelle JS, Taha TY, Lemak S, Yin S, Shuvalova L, Rosecrans J, Khanna K, Seifert HS, Savchenko A, Stogios PJ, Ott M, Satchell KJF. bioRxiv. 2024 Aug 14. - Immediate myeloid depot for SARS-CoV-2 in the human lung.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Sci Adv. 2024 Aug 02; 10(31):eadm8836. - NF-ÎşB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
Simoneau CR, Chen PY, Xing GK, Hayashi JM, Chen IP, Khalid MM, Meyers NL, Taha TY, Leon KE, Suryawanshi RK, McCavitt-Malvido M, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose JP, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. Sci Rep. 2024 07 04; 14(1):15351. - Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid.
Zhao H, Syed AM, Khalid MM, Nguyen A, Ciling A, Wu D, Yau WM, Srinivasan S, Esposito D, Doudna JA, Piszczek G, Ott M, Schuck P. Nucleic Acids Res. 2024 Jun 24; 52(11):6647-6661. - Colloidal Aggregation Confounds Cell-Based Covid-19 Antiviral Screens.
Glenn IS, Hall LN, Khalid MM, Ott M, Shoichet BK. J Med Chem. 2024 Jun 27; 67(12):10263-10274. - CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.
Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ. mBio. 2024 Apr 10; 15(4):e0222223. - Assembly reactions of SARS-CoV-2 nucleocapsid protein with nucleic acid.
Zhao H, Syed AM, Khalid MM, Nguyen A, Ciling A, Wu D, Yau WM, Srinivasan S, Esposito D, Doudna JA, Piszczek G, Ott M, Schuck P. bioRxiv. 2023 Nov 23. - Protocol for an in vitro assay to study HIV-1 Tat methylation.
Boehm D, Kaehlcke K, Schnoelzer M, Ott M. Protocol for an in vitro assay to study HIV-1 Tat methylation. STAR Protoc. 2023 Dec 15; 4(4):102687. - A flow cytometry-based assay to investigate HIV-1 expression in SMYD5 shRNA containing primary CD4+ T cells.
Boehm D, Ott M. A flow cytometry-based assay to investigate HIV-1 expression in SMYD5 shRNA containing primary CD4+ T cells. STAR Protoc. 2023 Dec 15; 4(4):102694. - Hepatitis C virus infects and perturbs liver stem cells.
Meyers NL, Ashuach T, Lyons DE, Khalid MM, Simoneau CR, Erickson AL, Bouhaddou M, Nguyen TT, Kumar GR, Taha TY, Natarajan V, Baron JL, Neff N, Zanini F, Mahmoudi T, Quake SR, Krogan NJ, Cooper S, McDevitt TC, Yosef N, Ott M. mBio. 2023 Dec 19; 14(6):e0131823. - Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination.
Suryawanshi RK, Taha TY, McCavitt-Malvido M, Silva I, Khalid MM, Syed AM, Chen IP, Saldhi P, Sreekumar B, Montano M, Foresythe K, Tabata T, Kumar GR, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Kojima N, Arellanor T, Bussanich A, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Wang Y, Ghazarian S, Davis G, Rodriguez D, Doudna J, Spraggon L, Chiu CY, Ott M. Emerg Microbes Infect. 2023 Dec; 12(2):2270071. - Colloidal aggregation confounds cell-based Covid-19 antiviral screens.
Glenn IS, Hall LN, Khalid MM, Ott M, Shoichet BK. bioRxiv. 2023 Oct 30. - HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O'Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M. Viruses. 2023 10 28; 15(11). - Post-acute immunological and behavioral sequelae in mice after Omicron infection.
Ma T, Suryawanshi RK, Miller SR, Ly KK, Thomas R, Elphick N, Yin K, Luo X, Kaliss N, Chen IP, Montano M, Sreekumar B, Standker L, MĂĽnch J, Heath Damron F, Palop JJ, Ott M, Roan NR. bioRxiv. 2023 Oct 04. - Comprehensive synergy mapping links a BAF- and NSL-containing "supercomplex" to the transcriptional silencing of HIV-1.
Li Z, Deeks SG, Ott M, Greene WC. Cell Rep. 2023 Sep 26; 42(9):113055. - A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, McCavitt-Malvido M, O'Leary PC, Jogalekar MP, Diolaiti ME, Kimmerly GR, Tsou CL, Gascon R, Montano M, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. PLoS Pathog. 2023 08; 19(8):e1011614. - SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cells.
Kim IJ, Lee YH, Khalid MM, Chen IP, Zhang Y, Ott M, Verdin E. J Biol Chem. 2023 08; 299(8):104955. - Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.
Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N. RSC Adv. 2023 Jun 09; 13(26):17667-17677. - Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Upadhyay V, Suryawanshi RK, Tasoff P, McCavitt-Malvido M, Kumar RG, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha CWY, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ. mBio. 2023 08 31; 14(4):e0088923. - Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.
Singh I, Li F, Fink EA, Chau I, Li A, Rodriguez-Hernández A, Glenn I, Zapatero-BelinchĂłn FJ, Rodriguez ML, Devkota K, Deng Z, White K, Wan X, Tolmachova NA, Moroz YS, Kaniskan HĂś, Ott M, GarcĂa-Sastre A, Jin J, Fujimori DG, Irwin JJ, Vedadi M, Shoichet BK. J Med Chem. 2023 06 22; 66(12):7785-7803. - A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. bioRxiv. 2023 May 10. - Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.
Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Renuka Kumar G, Wyman S, Doudna JA, Ott M. Nat Commun. 2023 04 21; 14(1):2308. - A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.
Han H, Gracia AV, Røise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakhshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N. RSC Adv. 2023 Apr 03; 13(16):10636-10641. - The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11.
Boehm D, Lam V, Schnolzer M, Ott M. Cell Rep. 2023 03 28; 42(3):112234. - SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. Stem Cell Reports. 2023 03 14; 18(3):636-653. - Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6.
Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, Kumar GR, Wyman S, Doudna JA, Ott M. bioRxiv. 2023 Feb 09. - Nuclear accumulation of host transcripts during Zika Virus Infection.
Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, Kaye J, Shah PS, Finkbeiner S, Krogan NJ, Bertozzi C, Carette JE, Ott M. PLoS Pathog. 2023 01; 19(1):e1011070. - Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Upadhyay V, Suryawanshi R, Tasoff P, McCavitt-Malvido M, Kumar GR, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha C, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ. bioRxiv. 2022 Dec 08. - Neutralizing Immunity Induced Against the Omicron BA.1 and BA.2 Variants in Vaccine Breakthrough Infections.
Brazer N, Morris MK, Servellita V, Anglin K, Saldhi P, Garcia-Knight M, Bethancourt S, Sotomayor-Gonzalez A, Wang B, Foresythe A, Nguyen J, Gliwa AS, Pineda-Ramirez J, Sanchez RD, Zhang Y, Ott M, Wadford DA, Andino R, Kelly JD, Hanson C, Chiu CY. J Infect Dis. 2022 11 11; 226(10):1688-1698. - Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons.
Kong W, Montano M, Corley MJ, Helmy E, Kobayashi H, Kinisu M, Suryawanshi R, Luo X, Royer LA, Roan NR, Ott M, Ndhlovu LC, Greene WC. mBio. 2022 12 20; 13(6):e0230822. - Viral Hijacking of BET Proteins.
Chen IP, Ott M. Viruses. 2022 10 17; 14(10). - SARS-CoV-2 hybrid immunity: silver bullet or silver lining?
Suryawanshi R, Ott M. Nat Rev Immunol. 2022 10; 22(10):591-592. - SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Soveg FW, Gross JD, Krogan NJ, Jerome KR, Schilling B, Ott M, Verdin E. PLoS Pathog. 2022 09; 18(9):e1010811. - Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, HĂĽttenhain R, Carette JE, Krogan NJ. Nat Commun. 2022 09 08; 13(1):5282. - Catching BETs by viruses.
Zandian M, Chen IP, Byrareddy SN, Fujimori DG, Ott M, Kutateladze TG. Biochim Biophys Acta Gene Regul Mech. 2022 10; 1865(7):194859. - NF-ÎşB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.
Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. bioRxiv. 2022 Aug 02. - Taking cues from convalescence to improve vaccines against hepatitis C virus.
Sreekumar BK, Taha TY, Ott M. J Clin Invest. 2022 08 01; 132(15). - A Single-Component Luminescent Biosensor for the SARS-CoV-2 Spike Protein.
Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak JE, Ott M, Ting AY. J Am Chem Soc. 2022 08 03; 144(30):13663-13672. - Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott M, Doudna JA. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2200592119. - Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants.
Yu B, Li S, Tabata T, Wang N, Cao L, Kumar GR, Sun W, Liu J, Ott M, Wang L. Chem. 2022 Oct 13; 8(10):2766-2783. - Tropism of SARS-CoV-2 for human cortical astrocytes.
Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2122236119. - Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2.
Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Khalid MM, Taha TY, Tabata T, Hayashi JM, Soveg FW, Carlson-Stevermer J, Gupta M, Zhang MY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, Krogan N, Fujimori DG, Ott M. Cell Rep. 2022 07 19; 40(3):111088. - Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination.
Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, Gonzalez VJ, Lin CY, Jigmeddagva U, Chidboy MA, Montano M, Taha TY, Khalid MM, Sreekumar B, Hayashi JM, Chen PY, Kumar GR, Warrier L, Wu AH, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens J, Rincon M, Myatt L, Asiodu IV, Flaherman VJ, Afshar Y, Jacoby VL, Murtha AP, Robinson JF, Ott M, Greene WC, Gaw SL. JCI Insight. 2022 06 22; 7(12). - A single-component luminescent biosensor for the SARS-CoV-2 spike protein.
Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak J, Ott M, Ting AY. bioRxiv. 2022 Jun 15. - Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. Nature. 2022 07; 607(7918):351-355. - Immediate myeloid depot for SARS-CoV-2 in the human lung.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Res Sq. 2022 May 17. - Immediate myeloid depot for SARS-CoV-2 in the human lung.
Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. bioRxiv. 2022 May 11. - Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants.
Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, Hackett J, Andino R, Wadford DA, Hanson C, Doudna J, Ott M, Chiu CY. Cell. 2022 04 28; 185(9):1539-1548.e5. - Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants.
Yu B, Li S, Tabata T, Wang N, Kumar GR, Liu J, Ott MM, Wang L. bioRxiv. 2022 Mar 14. - Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system.
Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M. Open Biol. 2022 03; 12(3):210320. - Limited Cross-Variant Immunity after Infection with the SARS-CoV-2 Omicron Variant Without Vaccination.
Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna J, Ott M. medRxiv. 2022 Feb 09. - SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E. bioRxiv. 2022 Jan 05. - Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA. medRxiv. 2022 Jan 02. - Viral E Protein Neutralizes BET Protein-Mediated Post-Entry Antagonism of SARS-CoV-2.
Chen IP, Longbotham JE, McMahon S, Suryawanshi RK, Carlson-Stevermer J, Gupta M, Zhang MY, Soveg FW, Hayashi JM, Taha TY, Lam VL, Li Y, Yu Z, Titus EW, Diallo A, Oki J, Holden K, QCRG Structural Biology Consortium, Krogan N, Galonic Fujimori D, Ott M. bioRxiv. 2021 Nov 15. - Identification of a therapeutic interfering particle-A single-dose SARS-CoV-2 antiviral intervention with a high barrier to resistance.
Chaturvedi S, Vasen G, Pablo M, Chen X, Beutler N, Kumar A, Tanner E, Illouz S, Rahgoshay D, Burnett J, Holguin L, Chen PY, Ndjamen B, Ott M, Rodick R, Rogers T, Smith DM, Weinberger LS. Cell. 2021 12 09; 184(25):6022-6036.e18. - Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles.
Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA. Science. 2021 Dec 24; 374(6575):1626-1632. - Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases.
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, DĂaz de LeĂłn Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Nat Chem Biol. 2021 Nov; 17(11):1210. - Accelerated RNA detection using tandem CRISPR nucleases.
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, DĂaz de LeĂłn Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim S, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Nat Chem Biol. 2021 09; 17(9):982-988. - Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.
Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA. ACS Infect Dis. 2021 08 13; 7(8):2337-2351. - Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.
Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, GarcĂa-Sastre A, Ott M, Sirota M. Sci Rep. 2021 06 10; 11(1):12310. - SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. bioRxiv. 2021 Jun 02. - Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F, QCRG Structural Biology Consortium, Kumar GR, Ott M, Baker D, El-Samad H. bioRxiv. 2021 Apr 20. - Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant.
Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Sanchez San Martin C, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi JM, Simoneau CR, Kumar GR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Frankino PA, Shivram H, Lareau LF, Wyman SK, Ott M, Andino R, Chiu CY. Cell. 2021 06 24; 184(13):3426-3437.e8. - Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts.
Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA. Methods. 2022 05; 201:15-25. - Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.
Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, GarcĂa-Sastre A, Ott M, Sirota M. Res Sq. 2021 Mar 30. - Accelerated RNA detection using tandem CRISPR nucleases.
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de LeĂłn Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim SE, Dugan EJ, IGI Testing Consortium, Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. medRxiv. 2021 Mar 24. - A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection.
Kulsuptrakul J, Wang R, Meyers NL, Ott M, Puschnik AS. Cell Rep. 2021 03 16; 34(11):108859. - SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.
Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC. Sci Transl Med. 2021 04 21; 13(590). - Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation.
Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Martin CSS, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Kumar GR, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi J, Simoneau CR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Lareau LF, Frankino PA, Shivram H, Wyman SK, Ott M, Andino R, Chiu CY. medRxiv. 2021 Mar 09. - Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA.
Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. J Virol Methods. 2021 06; 292:114115. - Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. J Virol. 2021 03 25; 95(8). - Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.
Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR. bioRxiv. 2021 Jan 18. - Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2.
Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA. bioRxiv. 2021 Jan 12. - Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Nat Metab. 2021 Jan; 3(1):120-121. - Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Cell. 2021 01 07; 184(1):106-119.e14. - Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy.
Fozouni P, Son S, DĂaz de LeĂłn Derby M, Knott GJ, Gray CN, D'Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, Harris AR, Chen PY, Osterloh JM, Meyer-Franke A, Joehnk B, Walcott K, Sil A, Langelier C, Pollard KS, Crawford ED, Puschnik AS, Phelps M, Kistler A, DeRisi JL, Doudna JA, Fletcher DA, Ott M. Cell. 2021 01 21; 184(2):323-333.e9. - Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology.
Simoneau CR, Ott M. Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology. Cell Stem Cell. 2020 12 03; 27(6):859-868. - Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F. Cell Stem Cell. 2020 12 03; 27(6):876-889.e12. - Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Nat Metab. 2020 11; 2(11):1265-1283. - An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, GarcĂa-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. Science. 2020 12 18; 370(6523):1473-1479. - Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, HĂĽttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, GarcĂa-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. Science. 2020 12 04; 370(6521). - SIRT1 is downregulated by autophagy in senescence and ageing.
Xu C, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, Lu C, Nicastri M, Bretz C, Winkler JD, Amaravadi R, Garcia BA, Adams PD, Ott M, Tong W, Johansen T, Dou Z, Berger SL. Nat Cell Biol. 2020 10; 22(10):1170-1179. - Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses.
Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi JM, Carlson-Stevermer J, Oki J, Holden K, Krogan NJ, Ott M, Puschnik AS. bioRxiv. 2020 Sep 24. - SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
PĂ©rez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC. bioRxiv. 2020 Sep 12. - Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Cell Stem Cell. 2020 11 05; 27(5):840-851.e6. - An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, GarcĂa-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. bioRxiv. 2020 Aug 17. - Turning up the heat on HIV-1.
Chen IP, Ott M. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16109-16111. - The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Bouhaddou M, Memon D, Meyer B, White KM, Rezelj VV, Correa Marrero M, Polacco BJ, Melnyk JE, Ulferts S, Kaake RM, Batra J, Richards AL, Stevenson E, Gordon DE, Rojc A, Obernier K, Fabius JM, Soucheray M, Miorin L, Moreno E, Koh C, Tran QD, Hardy A, Robinot R, Vallet T, Nilsson-Payant BE, Hernandez-Armenta C, Dunham A, Weigang S, Knerr J, Modak M, Quintero D, Zhou Y, Dugourd A, Valdeolivas A, Patil T, Li Q, HĂĽttenhain R, Cakir M, Muralidharan M, Kim M, Jang G, Tutuncuoglu B, Hiatt J, Guo JZ, Xu J, Bouhaddou S, Mathy CJP, Gaulton A, Manners EJ, FĂ©lix E, Shi Y, Goff M, Lim JK, McBride T, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, De Wit E, Leach AR, Kortemme T, Shoichet B, Ott M, Saez-Rodriguez J, tenOever BR, Mullins RD, Fischer ER, Kochs G, Grosse R, GarcĂa-Sastre A, Vignuzzi M, Johnson JR, Shokat KM, Swaney DL, Beltrao P, Krogan NJ. Cell. 2020 08 06; 182(3):685-712.e19. - An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections.
Leon K, Ott M. Semin Cell Dev Biol. 2021 03; 111:101-107. - FOXO1 promotes HIV latency by suppressing ER stress in T cells.
Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M. Nat Microbiol. 2020 09; 5(9):1144-1157. - A combinatorial view of old and new RNA polymerase II modifications.
Lyons DE, McMahon S, Ott M. Transcription. 2020 04; 11(2):66-82. - A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, HĂĽttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, GarcĂa-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. Nature. 2020 07; 583(7816):459-468. - A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Wankowicz SA, Bohn M, Sharp PP, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Rosenberg OS, Verba KA, Agard D, Ott M, Emerman M, Ruggero D, GarcĂa-Sastre A, Jura N, von Zastrow M, Taunton J, Ashworth A, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. bioRxiv. 2020 Mar 27. - Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract.
Khan S, Lew I, Wu F, Fritts L, Fontaine KA, Tomar S, Trapecar M, Shehata HM, Ott M, Miller CJ, Sanjabi S. Nat Commun. 2019 09 25; 10(1):4344. - Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M. Mol Cell. 2019 06 20; 74(6):1164-1174.e4. - High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.
Schilling B, Meyer JG, Wei L, Ott M, Verdin E. Methods Mol Biol. 2019; 1983:3-16. - A BAF'ling Approach to Curing HIV.
Tomar S, Ali I, Ott M. Cell Chem Biol. 2018 12 20; 25(12):1441-1442. - How cells hush a viral invader.
Fozouni P, Ott M. Nature. 2018 12; 564(7735):193-194. - The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein.
Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. mBio. 2018 11 06; 9(6). - Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali I, Conrad RJ, Verdin E, Ott M. Chem Rev. 2018 02 14; 118(3):1216-1252. - Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.
Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M. J Exp Med. 2018 01 02; 215(1):51-62. - Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
Boehm D, Ott M. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S8-S22. - The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes.
Conrad RJ, Fozouni P, Thomas S, Sy H, Zhang Q, Zhou MM, Ott M. Mol Cell. 2017 Sep 21; 67(6):1001-1012.e6. - Flow Cytometric Analysis of HIV-1 Transcriptional Activity in Response to shRNA Knockdown in A2 and A72 J-Lat Cell Lines.
Boehm D, Ott M. Bio Protoc. 2017 Jun 05; 7(11). - Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines.
Boehm D, Ott M. Bio Protoc. 2017 May 20; 7(10). - SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M. Cell Host Microbe. 2017 May 10; 21(5):569-579.e6. - Retrovirus Integration: Some Assembly Required?
Ali I, Conrad RJ, Ott M. Cell Host Microbe. 2016 Dec 14; 20(6):702-704. - The mTOR Complex Controls HIV Latency.
Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. Cell Host Microbe. 2016 Dec 14; 20(6):785-797. - Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.
Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S. J Exp Med. 2016 12 12; 213(13):2913-2929. - Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions.
Ott M, Marques D, Funk C, Bailer SM. Virol J. 2016 Oct 20; 13(1):175. - International AIDS Society global scientific strategy: towards an HIV cure 2016.
Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. Nat Med. 2016 08; 22(8):839-50. - Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Elife. 2016 05 31; 5. - Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection.
Meyers NL, Fontaine KA, Kumar GR, Ott M. Curr Opin Cell Biol. 2016 08; 41:117-24. - The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7.
Ali I, Ramage H, Boehm D, Dirk LM, Sakane N, Hanada K, Pagans S, Kaehlcke K, Aull K, Weinberger L, Trievel R, Schnoelzer M, Kamada M, Houtz R, Ott M. J Biol Chem. 2016 07 29; 291(31):16240-8. - Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.
Conrad RJ, Ott M. ACS Chem Biol. 2016 Mar 18; 11(3):669-80. - Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures.
Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L. Mol Nutr Food Res. 2016 Mar; 60(3):661-71. - Subcellular trafficking and functional importance of herpes simplex virus type 1 glycoprotein M domains.
Striebinger H, Zhang J, Ott M, Funk C, Radtke K, Duron J, Ruzsics Z, Haas J, Lippé R, Bailer SM. J Gen Virol. 2015 Nov; 96(11):3313-3325. - Manipulation of the host protein acetylation network by human immunodeficiency virus type 1.
Jeng MY, Ali I, Ott M. Crit Rev Biochem Mol Biol. 2015; 50(4):314-25. - The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain.
Funk C, Ott M, Raschbichler V, Nagel CH, Binz A, Sodeik B, Bauerfeind R, Bailer SM. PLoS Pathog. 2015 Jun; 11(6):e1004957. - SIRT1 deacetylates RORÎłt and enhances Th17 cell generation.
Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. J Exp Med. 2015 Jun 01; 212(6):973. - SIRT1 deacetylates RORγt and enhances Th17 cell generation.
Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. J Exp Med. 2015 May 04; 212(5):607-17. - Membrane Flotation Assay.
Vogt DA, Ott M. Bio Protoc. 2015 Apr 05; 5(7). - Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.
Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. BMC Evol Biol. 2015 Mar 10; 15:35. - A combined proteomics/genomics approach links hepatitis C virus infection with nonsense-mediated mRNA decay.
Ramage HR, Kumar GR, Verschueren E, Johnson JR, Von Dollen J, Johnson T, Newton B, Shah P, Horner J, Krogan NJ, Ott M. Mol Cell. 2015 Jan 22; 57(2):329-340. - 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond.
Verdin E, Ott M. Nat Rev Mol Cell Biol. 2015 04; 16(4):258-64. - The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.
Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M. J Biol Chem. 2014 Dec 26; 289(52):35770-80. - Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.
Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Mol Cell. 2013 Nov 07; 52(3):314-24. - Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus.
Webster B, Ott M, Greene WC. J Virol. 2013 Dec; 87(24):13354-69. - Acetylphosphate: a novel link between lysine acetylation and intermediary metabolism in bacteria.
Verdin E, Ott M. Mol Cell. 2013 Jul 25; 51(2):132-4. - Bromodomain proteins in HIV infection.
Boehm D, Conrad RJ, Ott M. Viruses. 2013 Jun 21; 5(6):1571-86. - Three rules for HIV latency: location, location, and location.
Ott M, Verdin E. Cell Host Microbe. 2013 Jun 12; 13(6):625-6. - How the antiviral immune response boosts liver fat.
Camus G, Ott M. Nat Med. 2013 Jun; 19(6):671-2. - Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein.
Vogt DA, Camus G, Herker E, Webster BR, Tsou CL, Greene WC, Yen TS, Ott M. PLoS Pathog. 2013; 9(4):e1003302. - Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M. J Biol Chem. 2013 Apr 05; 288(14):9915-9923. - Snapshots: chromatin control of viral infection.
Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. Virology. 2013 Jan 05; 435(1):141-56. - Lipid droplets and viral infections.
Camus G, Vogt DA, Kondratowicz AS, Ott M. Methods Cell Biol. 2013; 116:167-90. - Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis.
Webster B, Wissing S, Herker E, Ott M, Greene WC. J Virol. 2013 Jan; 87(1):581-96. - Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M. J Immunol. 2012 Mar 15; 188(6):2712-21. - BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. Cell Cycle. 2013 Feb 01; 12(3):452-62. - The control of HIV transcription: keeping RNA polymerase II on track.
Ott M, Geyer M, Zhou Q. Cell Host Microbe. 2011 Nov 17; 10(5):426-35. - Emerging role of lipid droplets in host/pathogen interactions.
Herker E, Ott M. J Biol Chem. 2012 Jan 20; 287(4):2280-7. - Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.
Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M. J Biol Chem. 2012 Jan 06; 287(2):1090-9. - Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.
Harris C, Herker E, Farese RV, Ott M. J Biol Chem. 2011 Dec 09; 286(49):42615-42625. - Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).
Sakane N, Kwon HS, Pagans S, Kaehlcke K, Mizusawa Y, Kamada M, Lassen KG, Chan J, Greene WC, Schnoelzer M, Ott M. PLoS Pathog. 2011 Aug; 7(8):e1002184. - Functional characterization of the essential tail anchor of the herpes simplex virus type 1 nuclear egress protein pUL34.
Ott M, Tascher G, HaĂźdenteufel S, Zimmermann R, Haas J, Bailer SM. J Gen Virol. 2011 Dec; 92(Pt 12):2734-2745. - Unique ties between hepatitis C virus replication and intracellular lipids.
Herker E, Ott M. Trends Endocrinol Metab. 2011 Jun; 22(6):241-8. - HIV never ceases to surprise: Innovative methods in the quest for a cure.
Ott M. Methods. 2011 Jan; 53(1):1-2. - Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. Nat Med. 2010 Nov; 16(11):1295-8. - Acetylation of tau inhibits its degradation and contributes to tauopathy.
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Neuron. 2010 Sep 23; 67(6):953-66. - Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies.
Pagans S, Sakane N, Schnölzer M, Ott M. Methods. 2011 Jan; 53(1):91-6. - CYCLINg through transcription: posttranslational modifications of P-TEFb regulate transcription elongation.
Cho S, Schroeder S, Ott M. Cell Cycle. 2010 May; 9(9):1697-705. - HAT trick: p300, small molecule, inhibitor.
Ott M, Verdin E. Chem Biol. 2010 May 28; 17(5):417-8. - The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.
Pagans S, Kauder SE, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel RC, Verdin E, Schnolzer M, Ott M. Cell Host Microbe. 2010 Mar 18; 7(3):234-44. - Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.
Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M. EMBO J. 2009 May 20; 28(10):1407-17. - Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR.
Ott M, Fricker G, Bauer B. J Pharmacol Exp Ther. 2009 Apr; 329(1):141-9. - Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.
Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. J Neurosci. 2008 Nov 19; 28(47):12305-17. - The ups and downs of SIRT1.
Kwon HS, Ott M. Trends Biochem Sci. 2008 Nov; 33(11):517-25. - Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation.
Kwon HS, Brent MM, Getachew R, Jayakumar P, Chen LF, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M. Cell Host Microbe. 2008 Mar 13; 3(3):158-67. - Recruitment and activation of RSK2 by HIV-1 Tat.
Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. PLoS One. 2007 Jan 17; 2(1):e151. - Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPH.
Nieters A, Kallinowski B, Brennan P, Ott M, Maynadié M, Benavente Y, Foretova L, Cocco PL, Staines A, Vornanen M, Whitby D, Boffetta P, Becker N, De Sanjosé S. Gastroenterology. 2006 Dec; 131(6):1879-86. - The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.
Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. J Biol Chem. 2006 Jul 21; 281(29):19960-8. - Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry.
Dormeyer W, Ott M, Schnölzer M. Methods. 2005 Aug; 36(4):376-82. - Decoding Tat: the biology of HIV Tat posttranslational modifications.
Hetzer C, Dormeyer W, Schnölzer M, Ott M. Microbes Infect. 2005 Oct; 7(13):1364-9. - Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays.
Dormeyer W, Ott M, Schnölzer M. Mol Cell Proteomics. 2005 Sep; 4(9):1226-39. - SIRT1 regulates HIV transcription via Tat deacetylation.
Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, Dorr A, Hetzer-Egger C, Henklein P, Frye R, McBurney MW, Hruby H, Jung M, Verdin E, Ott M. PLoS Biol. 2005 Feb; 3(2):e41. - Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif.
Schwer B, Ren S, Pietschmann T, Kartenbeck J, Kaehlcke K, Bartenschlager R, Yen TS, Ott M. J Virol. 2004 Aug; 78(15):7958-68. - HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.
Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur AS. Mol Cell. 2004 Jan 30; 13(2):179-90. - Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.
Ott M, Dorr A, Hetzer-Egger C, Kaehlcke K, Schnolzer M, Henklein P, Cole P, Zhou MM, Verdin E. Novartis Found Symp. 2004; 259:182-93; discussion 193-6, 223-5. - Acetylation of the HIV-1 Tat protein: an in vitro study.
Dormeyer W, Dorr A, Ott M, Schnölzer M. Anal Bioanal Chem. 2003 Aug; 376(7):994-1005. - Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Mol Cell. 2003 Jul; 12(1):167-76. - Release and intercellular transfer of cell surface CD81 via microparticles.
Fritzsching B, Schwer B, Kartenbeck J, Pedal A, Horejsi V, Ott M. J Immunol. 2002 Nov 15; 169(10):5531-7. - The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.
Schwer B, North BJ, Frye RA, Ott M, Verdin E. J Cell Biol. 2002 Aug 19; 158(4):647-57. - Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.
Dorr A, Kiermer V, Pedal A, Rackwitz HR, Henklein P, Schubert U, Zhou MM, Verdin E, Ott M. EMBO J. 2002 Jun 03; 21(11):2715-23. - Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM. Mol Cell. 2002 Mar; 9(3):575-86.
Contact
Melanie Ott
Email
415.734.4807
Alia Aguilar
Administrative Associate
415.734.2725
Email