Gladstone-UCSF Institute of Genomic Immunology Seminar
Christine Brown, PhD
Christine Brown, PhD, is a faculty member in the departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology. As deputy director of the T Cell Therapeutics Research Laboratories, Brown, The Heritage Provider Network Professor in Immunotherapy, provides scientific oversight for the preclinical research program, as well as the ongoing clinical trial program focused on the development of CAR-engineered T cells for the treatment of hematological malignancies and solid tumors. Dr. Brown’s personal research efforts are focused on developing and refining redirected CAR T cells for the treatment of malignant brain tumors.
Brown received her doctoral degree from University of California, Berkeley, and was a Leukemia & Lymphoma Scholar during her postdoctoral fellowship at Pennsylvania State University. Her scientific contributions to the development and optimization of tumor-specific CAR T cells for the treatment of glioblastoma are supported by the California Institute for Regenerative Medicine and are the basis of an ongoing phase I clinical trial which is supported by Gateway for Cancer Research and R01 FD005129.
Within the Brown Lab, one major area of research focus is the development of CAR T cell therapy for the treatment of glioblastoma (GBM), the most common and aggressive type of adult primary brain tumor. Ongoing projects include addressing the challenge of tumor heterogeneity to reduce the potential of tumor antigen escape, overcoming the suppressive tumor micro-environment to improve CAR T cell function, monitoring tumor trafficking, optimizing CAR T cell route of delivery, and improving CAR T cell manufacturing. Other areas of interest include understanding the interplay between CAR T cells and the host immune micro-environment, functionalizing CARs using the meditope cyclic peptide technology and CRISPR/Cas9 modification of CAR T cells for improved functionality.
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Audience
Gladstone and UCSFContact(s)
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The Gladstone-UCSF Institute of Genomic Immunology Seminar Series showcases speakers at the intersection of genomic technology and immunology research with an aim to engineer the human immune system for therapeutic benefit. Speakers span technology development, synthetic biology, bioengineering, and the development and clinical application of immunotherapy. These talks are open to the Gladstone and UCSF communities.
Diversity, Equity, and Inclusion
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