Welcome to Lab Notes Volume 4, Issue 3 |
Last month I shared the news that we have acquired more than 100,000 sq ft of additional lab space and highlighted some of the incredible science driving our plans to expand. To give you a quick look inside the new space, I recorded a short walkthrough and am thrilled to share that we are on track to complete the build out and be fully operational by early 2027. Anyone who has ever taken on a complex building project can appreciate what an accomplishment that would be!
This expansion gives us an opportunity to double down on our strengths and add critical scientific expertise, particularly within our immunotherapy and AI efforts. See below for an update on the new trails we are blazing in AI, cancer, and Alzheimer's research that would have been hard to imagine even a few years ago.
To see how these efforts come together, I invite you to watch a short new video: Catalyze Breakthroughs. With gratitude, |
President, Gladstone Institutes |
1 ] AI Breakthrough Could Change How We Age |
Scientists in Christina Theodoris’s lab have collaborated with Nvidia to describe a new AI model that predicts how human cells age over time. The tool, called MaxToki, was trained on nearly 1 trillion data points and can identify targets to slow age-related decline in our cells. Published on the preprint server bioRxiv, MaxToki is already identifying and validating new targets to fight age-related diseases of the heart and brain.
Read more >
See more > |
2 ] Could We Stop Alzheimer’s Before It Starts? |
Alzheimer’s may actually begin decades before noticeable memory loss. New findings from Yadong Huang’s lab reveal how the APOE4 gene disrupts brain circuits early and has even identified a potential therapeutic target to reverse these effects. The study, published in Nature Aging, offers new hope for AD prevention.
Read more > Hear more > |
3 ] Reprogramming the Body to Fight Cancer |
CAR-T therapy has revolutionized cancer treatment, but it requires an elaborate process: extracting a patient’s immune cells, shipping them to a specialized facility where they’re genetically reprogrammed to fight cancer, then infusing them back into a patient’s bloodstream. This costly and time consuming method places CAR-T therapy out of reach for thousands of patients.
A new approach from Justin Eyquem’s lab, published in Nature, allows scientists to engineer cancer-fighting T cells directly inside the body with precise gene editing. This breakthrough could make powerful immunotherapies more accessible for patients with cancer, autoimmune diseases, and more.
Read more >
Hear more > |
If you enjoyed this email, forward it to a friend, and if you're seeing this for the first time, subscribe to get monthly updates on Gladstone's discoveries. |
|
|
|
