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Chen, J.S., Ma, E., Harrington, L.B., Da Costa, M., Tian, X., Palefsky, J.M., and Doudna, J.A. (2018) CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity. Science 360, 436-439.

Harrington, L.B., Doxzen, K.W., Ma, E., Liu, J., Knott, G.J., Edraki, A., Amrani, N., Chen, J.S., Cofsky, J.C., Kranzusch, P.J., Sontheimer, E.J., Davidson, A.R., Maxwell, K.L. and Doudna, J.A. (2017) A broad-spectrum inhibitor of CRISPR-Cas9. Cell 170, 1224-1233.e15.

Wright, A.V., Liu, J.J., Knott, G.J., Doxzen, K.W., Nogales, E. and Doudna, J.A. (2017) Structures of the CRISPR genome integration complex. Science 357, 1113-1118.

Nelles, D.A., Fang, M.Y., O'Connell, M.R., Xu, J.L., Markmiller, S.J., Doudna, J.A. and Yeo, G.W. (2016) Programmable RNA tracking in live cells with CRISPR-Cas9. Cell 65, 488-496.

Nuñez, J.K., Harrington, L.B., Kranzusch, P.J., Engelman, A. and Doudna, J.A. (2015) Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature 527, 535-8.

Sternberg, S.H., LaFrance, B., Kaplan, M. and Doudna, J.A. (2015) Conformational control of DNA target cleavage by CRISPR-Cas9. Nature 527,110-113.

Jiang, F., Zhou, K., Ma, K., Gressel, S. and Doudna, J.A. (2015) A Cas9-guide RNA complex pre-organized for target DNA recognition. Science 348,1477-81.

O’Connell, M.R., Oakes, B.L., Sternberg, S.H., East-Seletsky, A., Kaplan, M. and Doudna, J.A. (2014) Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature 516, 263-6.

Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E. and Doudna, J.A. (2014) Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science 343, 1247997.

Sternberg, S.H., Redding, S., Jinek, M.J., Greene, E.C. and Doudna, J.A. (2014) DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507, 62-7. (cover article; Perspective in Science published May 2014).

Lo, T.W., Pickle, C.S., Lin, S., Ralston, E.J., Gurling, M., Schartner, C.M., Bian, Q., Doudna, J.A. and Meyer, B.J. (2013) Heritable genome editing using TALENs and CRISPR/Cas9 to engineer precise insertions and deletions in evolutionarily diverse nematode species. Genetics 195, 331-48.

Pattanayak, V., Lin, S., Guilinger, J.P., Ma, E., Doudna, J.A. and Liu, D.R. (2013) High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nature Biotechnol. 31, 839-43.

Gilbert, L.A., Larson, M.H., Morsut, L., Liu, Z., Brar, G.A., Torres, S.E., Stern-Ginossar, N., Brandman, 8 O., Whitehead, E.H., Doudna, J.A., Lim, W.A., Weissman, J.S. and Qi, L.S. (2013) CRISPR mediated modular RNA-guided regulation of transcription in eukaryotes. Cell 154, 442-51.

Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. (2013) Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173-83.

Jinek, M., East, A., Cheng, A., Ma, E. and Doudna, J.A. (2013) RNA-programmed genome editing in human cells. eLife 2, e00471.

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., *Doudna, J.A. and *Charpentier E. (2012) A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity. Science 337, 816-21.  *corresponding authors

Wiedenheft, B., Lander, G.C., Zhou, K., Jore, M.M., Brouns, S.J., van der Oost, J., Doudna, J.A. and Nogales, E. (2011) Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature 477, 486-9.

Sashital, D.G., Jinek, M. and Doudna, J.A. (2011) An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nature Struct. Mol. Biol. 18, 680-7. PMID: 21572442.

Wiedenheft, B., van Duijn, E., Bultema, J., Waghmare, S., Zhou, K., Barendregt, A., Westphal, W., Heck, A., Boekema, E., Dickman, M. and Doudna, J.A. (2011) RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc. Natl. Acad. Sci. USA 108, 10092-7.

Jore, M.M., Lundgren, M., van Duijn, E., Bultema, J.B., Westra, E.R., Waghmare, S.P., Wiedenheft, B., Pul, U., Wurm, R., Wagner, R., Beijer, M.R., Barendregt, A., Zhou, K., Snijders, A.P., Dickman, M.J., Doudna, J.A., Boekema, E.J., Heck, A.J., van der Oost, J., Brouns, S.J. (2011) Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature Struct. Mol. Biol. 18, 529- 36. 

Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K. and Doudna, J.A. (2010) Sequence- and structurespecific RNA processing by a CRISPR endonuclease. Science 329, 1355-8.