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Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM-Y, Baumgart M, Banerjee S, Beck C, Blennow K et al..  2012.  Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit.. Alzheimers Dement. 8(5):445-52.
Hodoglugil U, Mahley RW.  2012.  Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations.. Ann Hum Genet. 76(2):128-41.
Chen H-K, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji Z-S, Balestra ME, Walker DW et al..  2012.  Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.. J Biol Chem. 287(8):5253-66.
Mahley RW, Huang Y.  2012.  Apolipoprotein e sets the stage: response to injury triggers neuropathology.. Neuron. 76(5):871-85.
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, S An S, Hester JM, Cooke JN, Bostrom MA, Rudock ME et al..  2012.  A genome-wide association search for type 2 diabetes genes in African Americans.. PLoS One. 7(1):e29202.
Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen L-P et al..  2012.  Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.. PLoS Genet. 8(3):e1002607.
Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong D-eun, Pleiss M, McComas C, Hess F, Witter D et al..  2011.  Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.. J Biol Chem. 286(19):17217-26.
Hodoglugil U, Williamson DW, Yu Y, Farrer LA, Mahley RW.  2011.  Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks.. Ann Hum Genet. 75(3):398-417.
Chen H-K, Ji Z-S, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.  2011.  Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.. J Biol Chem. 286(7):5215-21.
Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JHua, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N et al..  2010.  Genetic variants influencing circulating lipid levels and risk of coronary artery disease.. Arterioscler Thromb Vasc Biol. 30(11):2264-76.
Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G et al..  2010.  Meta-analysis and imputation refines the association of 15q25 with smoking quantity.. Nat Genet. 42(5):436-40.
Hodoglugil U, Williamson DW, Mahley RW.  2010.  Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.. J Lipid Res. 51(2):422-30.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL et al..  2010.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.. Nat Genet. 42(2):105-16.
Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y.  2009.  GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.. Cell Stem Cell. 5(6):634-45.
J Richards B, Waterworth D, O'Rahilly S, Hivert M-F, Loos RJF, Perry JRB, Tanaka T, Timpson NJohn, Semple RK, Soranzo N et al..  2009.  A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.. PLoS Genet. 5(12):e1000768.
Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Y Kesaniemi A, Mahley RW, McPherson R, Waeber G, Bersot TP et al..  2009.  Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.. Obesity (Silver Spring). 17(4):737-44.
Mahley RW, Weisgraber KH, Huang Y.  2009.  Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.. J Lipid Res. 50 Suppl:S183-8.
Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID.  2008.  Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.. Obesity (Silver Spring). 16(11):2468-71.
Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois MV, Huang Y, Mahley RW, Dolan MJ et al..  2008.  Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.. Proc Natl Acad Sci U S A. 105(25):8718-23.
Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y.  2008.  Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.. Proc Natl Acad Sci U S A. 105(4):1343-6.
Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JHua, Song K, Yuan X, Johnson T, Ashford S et al..  2008.  LDL-cholesterol concentrations: a genome-wide association study.. Lancet. 371(9611):483-91.
Stirnadel H, Lin X, Ling H, Song K, Barter P, Y Kesaniemi A, Mahley RW, McPherson R, Waeber G, Bersot TP et al..  2008.  Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study.. Atherosclerosis. 197(2):868-76.
Barter P, Y McPherson R, Song K, Y Kesaniemi A, Mahley RW, Waeber G, Bersot TP, Mooser V, Waterworth D, Grundy SM.  2007.  Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia.. J Clin Endocrinol Metab. 92(6):2041-5.
Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW.  2007.  Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).. Pharmacogenomics J. 7(1):10-28.
Mahley RW, Huang Y, Weisgraber KH.  2007.  Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.. Curr Alzheimer Res. 4(5):537-40.
Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y.  2006.  Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.. J Neurosci. 26(19):4985-94.
Mahley RW, Huang Y, Weisgraber KH.  2006.  Putting cholesterol in its place: apoE and reverse cholesterol transport.. J Clin Invest. 116(5):1226-9.
Mahley RW, Bersot TP.  2006.  High density lipoprotein cholesterol in coronary artery patients: is it as low as expected? Anadolu Kardiyol Derg. 6(1):94-6;authorreply96.
Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW et al..  2006.  Human prions and plasma lipoproteins.. Proc Natl Acad Sci U S A. 103(30):11312-7.
Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW.  2006.  Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks.. J Lipid Res. 47(1):144-53.
Ji Z-S, Müllendorff K, Cheng IH, R Miranda D, Huang Y, Mahley RW.  2006.  Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.. J Biol Chem. 281(5):2683-92.
Mahley RW, Weisgraber KH, Huang Y.  2006.  Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.. Proc Natl Acad Sci U S A. 103(15):5644-51.
Yu Y, Wyszynski DF, Waterworth DM, Wilton SD, Barter PJ, Y Kesaniemi A, Mahley RW, McPherson R, Waeber G, Bersot TP et al..  2005.  Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.. J Lipid Res. 46(10):2202-13.
Wyszynski DF, Waterworth DM, Barter PJ, Cohen J, Y Kesaniemi A, Mahley RW, McPherson R, Waeber G, Bersot TP, Sharma SS et al..  2005.  Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project).. Am J Cardiol. 95(2):194-8.
Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW.  2005.  Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.. Proc Natl Acad Sci U S A. 102(51):18700-5.
Chang S, Ma Tran, R Miranda D, Balestra ME, Mahley RW, Huang Y.  2005.  Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.. Proc Natl Acad Sci U S A. 102(51):18694-9.
Mahley RW, Can S, Ozbayrakçi S, Bersot TP, Tanir S, K Palaoğlu E, Pépin GM.  2005.  Modulation of high-density lipoproteins in a population in istanbul, Turkey, with low levels of high-density lipoproteins.. Am J Cardiol. 96(4):547-55.
Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y.  2004.  Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.. J Biol Chem. 279(24):25511-6.
Harris FM, Tesseur I, Brecht WJ, Xu Q, Müllendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y.  2004.  Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.. J Biol Chem. 279(5):3862-8.
Shohet RV, Vega GL, Bersot TP, Mahley RW, Grundy SM, Guerra R, Cohen JC.  2002.  Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC).. Hum Mutat. 19(5):536-42.
Ji Z-S, R Miranda D, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW.  2002.  Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.. J Biol Chem. 277(24):21821-8.
Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV.  2002.  DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.. Clin Genet. 62(1):68-73.
Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW.  2001.  Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons.. Proc Natl Acad Sci U S A. 98(15):8838-43.
Dichek HL, Johnson SM, Akeefe H, Lo GT, Sage E, Yap CE, Mahley RW.  2001.  Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice.. J Lipid Res. 42(2):201-10.
Mahley RW, Arslan P, Pekcan G, Pépin GM, Ağaçdiken A, Karaağoğlu N, Rakicioğlu N, Nursal B, Dayanikli P, Palaoğlu KE et al..  2001.  Plasma lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL.. J Lipid Res. 42(12):1996-2006.
Nguyen TT, Kruckeberg KE, O'Brien JF, Ji ZS, Karnes PS, Crotty TB, Hay ID, Mahley RW, O'Brien T.  2000.  Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)].. J Clin Endocrinol Metab. 85(11):4354-8.
Mahley RW, Rall SC.  2000.  Apolipoprotein E: far more than a lipid transport protein.. Annu Rev Genomics Hum Genet. 1:507-37.
Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A.  2000.  Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages.. J Mol Med (Berl). 78(4):217-27.
Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW et al..  1999.  Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites.. Arterioscler Thromb Vasc Biol. 19(5):1306-15.
Bersot TP, Vega GL, Grundy SM, Palaoğlu KE, Atagündüz P, Ozbayrakçi S, Gökdemir O, Mahley RW.  1999.  Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population.. J Lipid Res. 40(3):432-8.
Mahley RW, Huang Y.  1999.  Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond.. Curr Opin Lipidol. 10(3):207-17.
Mahley RW, Rall SC.  1999.  Is epsilon4 the ancestral human apoE allele? Neurobiol Aging. 20(4):429-30.
Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW.  1999.  Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis.. Arterioscler Thromb Vasc Biol. 19(12):2952-9.
Huang Y, Liu XQ, Rall SC, Taylor JM, von Eckardstein A, Assmann G, Mahley RW.  1998.  Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia.. J Biol Chem. 273(41):26388-93.
Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM.  1998.  Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.. J Clin Invest. 101(10):2151-64.
Pitas RE, Ji ZS, Weisgraber KH, Mahley RW.  1998.  Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.. Biochem Soc Trans. 26(2):257-62.
Zhu Y, Bellosta S, Langer C, Bernini F, Pitas RE, Mahley RW, Assmann G, von Eckardstein A.  1998.  Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma.. Proc Natl Acad Sci U S A. 95(13):7585-90.
Vega GL, Gao J, Bersot TP, Mahley RW, Verstraete R, Grundy SM, White A, Cohen JC.  1998.  The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity.. J Lipid Res. 39(7):1520-4.
Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG et al..  1998.  Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake.. J Biol Chem. 273(4):1896-903.
Mahley RW.  1997.  The J. David Gladstone Institutes.. Mol Med. 3(9):569-71.
Huang Y, Rall SC, Mahley RW.  1997.  Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2.. Arterioscler Thromb Vasc Biol. 17(11):2817-24.
Hussain MM, Goldberg IJ, Weisgraber KH, Mahley RW, Innerarity TL.  1997.  Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity.. Arterioscler Thromb Vasc Biol. 17(7):1407-13.
McGeer PL, Walker DG, Pitas RE, Mahley RW, McGeer EG.  1997.  Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro.. Brain Res. 749(1):135-8.
Huang Y, Schwendner SW, Rall SC, Mahley RW.  1996.  Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.. J Biol Chem. 271(46):29146-51.
Weisgraber KH, Mahley RW.  1996.  Human apolipoprotein E: the Alzheimer's disease connection.. FASEB J. 10(13):1485-94.
Mahley RW, Nathan BP, Pitas RE.  1996.  Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease.. Ann N Y Acad Sci. 777:139-45.
Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL.  1995.  Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.. Proc Natl Acad Sci U S A. 92(21):9480-4.
Bellosta S, Nathan BP, Orth M, Dong LM, Mahley RW, Pitas RE.  1995.  Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth.. J Biol Chem. 270(45):27063-71.
Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE.  1995.  Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.. J Clin Invest. 96(5):2170-9.
Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE.  1995.  The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization.. J Biol Chem. 270(34):19791-9.
Mahley RW, Palaoğlu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V, Onat H, Fulks P, Mahley LL, Vakar F.  1995.  Turkish Heart Study: lipids, lipoproteins, and apolipoproteins.. J Lipid Res. 36(4):839-59.
Mahley RW, Nathan BP, Bellosta S, Pitas RE.  1995.  Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.. Curr Opin Lipidol. 6(2):86-91.
Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA.  1994.  Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.. J Biol Chem. 269(35):22358-65.
Mahley RW, Ji ZS, Brecht WJ, Miranda RD, He D.  1994.  Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism.. Ann N Y Acad Sci. 737:39-52.
Thomas DL, Mahley RW, Badur S, Palaoglu E, Quinn TC.  1994.  The epidemiology of hepatitis C in Turkey.. Infection. 22(6):411-4.
Fazio S, Sanan DA, Lee YL, Ji ZS, Mahley RW, Rall SC.  1994.  Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).. Arterioscler Thromb. 14(11):1873-9.
Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE.  1994.  Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.. Science. 264(5160):850-2.
Ji ZS, Lauer SJ, Fazio S, Bensadoun A, Taylor JM, Mahley RW.  1994.  Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.. J Biol Chem. 269(18):13429-36.
de Silva HV, Lauer SJ, Wang J, Simonet WS, Weisgraber KH, Mahley RW, Taylor JM.  1994.  Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.. J Biol Chem. 269(3):2324-35.
Fan J, Wang J, Bensadoun A, Lauer SJ, Dang Q, Mahley RW, Taylor JM.  1994.  Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.. Proc Natl Acad Sci U S A. 91(18):8724-8.
Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA.  1994.  Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.. Structure. 2(8):713-8.
Lüttmann S, von Eckardstein A, Wei W, Funke H, Köhler E, Mahley RW, Assmann G.  1994.  Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient.. J Lipid Res. 35(8):1431-40.
Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD.  1994.  Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.. J Clin Invest. 94(2):860-9.
Lund-Katz S, Weisgraber KH, Mahley RW, Phillips MC.  1993.  Conformation of apolipoprotein E in lipoproteins.. J Biol Chem. 268(31):23008-15.
Chiesa G, Johnson DF, Yao Z, Innerarity TL, Mahley RW, Young SG, Hammer RH, Hobbs HH.  1993.  Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA.. J Biol Chem. 268(32):23747-50.
Ji ZS, Brecht WJ, Miranda RD, Hussain MM, Innerarity TL, Mahley RW.  1993.  Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.. J Biol Chem. 268(14):10160-7.
de Silva HV, Lauer SJ, Mahley RW, Weisgraber KH, Taylor JM.  1993.  Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice.. Biochem Soc Trans. 21(2):483-7.
Thomas DL, Mahley RW, Badur S, Palaoğlu KE, Quinn TC.  1993.  Epidemiology of hepatitis E virus infection in Turkey.. Lancet. 341(8860):1561-2.
Bersot TP, Russell SJ, Thatcher SR, Pomernacki NK, Mahley RW, Weisgraber KH, Innerarity TL, Fox CS.  1993.  A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder.. J Lipid Res. 34(7):1149-54.
Schmidt EB, Illingworth DR, Bacon S, Mahley RW, Weisgraber KH.  1993.  Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100.. Atherosclerosis. 98(2):213-7.
Schmidt EB, Illingworth DR, Bacon S, Russell SJ, Thatcher SR, Mahley RW, Weisgraber KH.  1993.  Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100.. Metabolism. 42(2):137-9.
Illingworth DR, Vakar F, Mahley RW, Weisgraber KH.  1992.  Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100.. Lancet. 339(8793):598-600.
Rall SC, Mahley RW.  1992.  The role of apolipoprotein E genetic variants in lipoprotein disorders.. J Intern Med. 231(6):653-9.
Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA.  1991.  Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.. Science. 252(5014):1817-22.
Hussain MM, Maxfield FR, Más-Oliva J, Tabas I, Ji ZS, Innerarity TL, Mahley RW.  1991.  Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.. J Biol Chem. 266(21):13936-40.
Mahley RW, Weisgraber KH, Innerarity TL, Rall SC.  1991.  Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism.. JAMA. 265(1):78-83.
Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL.  1990.  Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.. J Biol Chem. 265(18):10771-9.
Crook D, Weisgraber KH, Boyles JK, Mahley RW.  1990.  Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets.. Arteriosclerosis. 10(4):633-47.
Crook D, Weisgraber KH, Rall SC, Mahley RW.  1990.  Isolation and characterization of several plasma apolipoproteins of common marmoset monkey.. Arteriosclerosis. 10(4):625-32.
Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, Grundy SM, Friedl W, Davignon J, McCarthy BJ.  1990.  Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.. J Lipid Res. 31(8):1337-49.
Weisgraber KH, Innerarity TL, Rall SC, Mahley RW.  1990.  Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E.. Ann N Y Acad Sci. 598:37-48.
Steinberg D, Carew TE, Fielding C, Fogelman AM, Mahley RW, Sniderman AD, Zilversmit DB.  1989.  Lipoproteins and the pathogenesis of atherosclerosis.. Circulation. 80(3):719-23.
Hussain MM, Mahley RW, Boyles JK, Lindquist PA, Brecht WJ, Innerarity TL.  1989.  Chylomicron metabolism. Chylomicron uptake by bone marrow in different animal species.. J Biol Chem. 264(30):17931-8.
Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ.  1989.  A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.. J Clin Invest. 83(3):1015-31.
Hussain MM, Mahley RW, Boyles JK, Fainaru M, Brecht WJ, Lindquist PA.  1989.  Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake.. J Biol Chem. 264(16):9571-82.
Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M.  1989.  Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.. J Clin Invest. 83(6):2125-30.
Weisgraber KH, Newhouse YM, Taylor JM, Tuan B, Nestruck AC, Davignon J, Mahley RW.  1989.  Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.. Arteriosclerosis. 9(1):50-7.
Mahley RW, Hui DY, Innerarity TL, Beisiegel U.  1989.  Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake.. Arteriosclerosis. 9(1 Suppl):I14-8.
Rall SC, Newhouse YM, Clarke HR, Weisgraber KH, McCarthy BJ, Mahley RW, Bersot TP.  1989.  Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.. J Clin Invest. 83(4):1095-101.
Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, Shooter EM, Gebicke-Haerter PJ.  1988.  Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state.. J Cell Biol. 107(3):1207-13.
Beisiegel U, Weber W, Havinga JR, Ihrke G, Hui DY, Wernette-Hammond ME, Turck CW, Innerarity TL, Mahley RW.  1988.  Apolipoprotein E-binding proteins isolated from dog and human liver.. Arteriosclerosis. 8(3):288-97.
Koo C, Wernette-Hammond ME, Garcia Z, Malloy MJ, Uauy R, East C, Bilheimer DW, Mahley RW, Innerarity TL.  1988.  Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors.. J Clin Invest. 81(5):1332-40.
Fainaru M, Funke H, Boyles JK, Ludwig EH, Innerarity TL, Mahley RW.  1988.  Metabolism of canine beta-very low density lipoproteins in normal and cholesterol-fed dogs.. Arteriosclerosis. 8(2):130-9.
Lalazar A, Weisgraber KH, Rall SC, Giladi H, Innerarity TL, Levanon AZ, Boyles JK, Amit B, Gorecki M, Mahley RW.  1988.  Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions.. J Biol Chem. 263(8):3542-5.
Weisgraber KH, Newhouse YM, Mahley RW.  1988.  Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes.. Biochem Biophys Res Commun. 157(3):1212-7.
Weisgraber KH, Innerarity TL, Newhouse YM, Young SG, Arnold KS, Krauss RM, Vega GL, Grundy SM, Mahley RW.  1988.  Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.. Proc Natl Acad Sci U S A. 85(24):9758-62.
Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, Grundy SM.  1987.  Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.. Proc Natl Acad Sci U S A. 84(19):6919-23.
Ignatius MJ, Shooter EM, Pitas RE, Mahley RW.  1987.  Lipoprotein uptake by neuronal growth cones in vitro.. Science. 236(4804):959-62.
Marcel YL, Innerarity TL, Spilman C, Mahley RW, Protter AA, Milne RW.  1987.  Mapping of human apolipoprotein B antigenic determinants.. Arteriosclerosis. 7(2):166-75.
Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW.  1987.  Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins.. Biochim Biophys Acta. 917(1):148-61.
Gebicke-Haerter PJ, Darby JK, Shooter EM, Riccardi VM, Weisgraber KH, Boyles JK, Mahley RW.  1987.  Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis.. Exp Neurol. 95(2):323-35.
Corsini A, Spilman CH, Innerarity TL, Arnold KS, Rall SC, Boyles JK, Mahley RW.  1987.  Receptor binding activity of lipid recombinants of apolipoprotein B-100 thrombolytic fragments.. J Lipid Res. 28(12):1410-23.
Innerarity TL, Young SG, Poksay KS, Mahley RW, Smith RS, Milne RW, Marcel YL, Weisgraber KH.  1987.  Structural relationship of human apolipoprotein B48 to apolipoprotein B100.. J Clin Invest. 80(6):1794-8.
Friedman G, Wernette-Hammond ME, Hui DY, Mahley RW, Innerarity TL.  1987.  Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.. J Lipid Res. 28(12):1482-94.
Ludwig EH, Blackhart BD, Pierotti VR, Caiati L, Fortier C, Knott T, Scott J, Mahley RW, Levy-Wilson B, McCarthy BJ.  1987.  DNA sequence of the human apolipoprotein B gene.. DNA. 6(4):363-72.
Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ.  1987.  Human apolipoprotein B: complete cDNA sequence and identification of structural domains of the protein.. Biochem Soc Trans. 15(2):195-9.
Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ.  1987.  Apolipoprotein B gene: plasma cholesterol and atherosclerosis.. Biochem Soc Symp. 53:155-63.
Innerarity TL, Weisgraber KH, Rall SC, Mahley RW.  1987.  Functional domains of apolipoprotein E and apolipoprotein B.. Acta Med Scand Suppl. 715:51-9.
Knott TJ, Wallis SC, Powell LM, Pease RJ, Lusis AJ, Blackhart B, McCarthy BJ, Mahley RW, Levy-Wilson B, Scott J.  1986.  Complete cDNA and derived protein sequence of human apolipoprotein B-100.. Nucleic Acids Res. 14(18):7501-3.
Mahley RW, Innerarity TL, Hui DY, Weisgraber KH, Pitas RE.  1986.  Pathology: plasma cholesterol levels determined by lipoprotein interactions with cell surface receptors.. West J Med. 145(3):372.
Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW.  1986.  Isolation and characterization of the apolipoprotein E receptor from canine and human liver.. J Biol Chem. 261(9):4256-67.
Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM.  1986.  Expression of the human apolipoprotein E gene in cultured mammalian cells.. J Biol Chem. 261(21):9858-64.
Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW.  1986.  Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages.. Arteriosclerosis. 6(1):114-22.
Weisgraber KH, Rall SC, Mahley RW, Milne RW, Marcel YL, Sparrow JT.  1986.  Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.. J Biol Chem. 261(5):2068-76.
Bersot TP, Innerarity TL, Pitas RE, Rall SC, Weisgraber KH, Mahley RW.  1986.  Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages.. J Clin Invest. 77(2):622-30.
Ignatius MJ, Gebicke-Härter PJ, Skene JH, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM.  1986.  Expression of apolipoprotein E during nerve degeneration and regeneration.. Proc Natl Acad Sci U S A. 83(4):1125-9.
Rall SC, Weisgraber KH, Mahley RW, Ehnholm C, Schamaun O, Olaisen B, Blomhoff JP, Teisberg P.  1986.  Identification of homozygosity for a human apolipoprotein A-I variant.. J Lipid Res. 27(4):436-41.
Innerarity TL, Hui DY, Bersot TP, Mahley RW.  1986.  Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions.. Adv Exp Med Biol. 201:273-88.
Rall SC, Weisgraber KH, Mahley RW.  1986.  Isolation and characterization of apolipoprotein E.. Methods Enzymol. 128:273-87.
Taylor JM, Mahley RW, Fukazawa C.  1986.  Cloning of the cDNA for rat and human apolipoprotein E mRNA.. Methods Enzymol. 128:801-11.
Weisgraber KH, Mahley RW.  1986.  Characterization of apolipoprotein E-containing lipoproteins.. Methods Enzymol. 129:145-66.
Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM.  1986.  Cloning and expression of the human apolipoprotein E gene.. Methods Enzymol. 128:811-23.
Innerarity TL, Pitas RE, Mahley RW.  1986.  Lipoprotein-receptor interactions.. Methods Enzymol. 129:542-65.
Mahley RW, Innerarity TL, Weisgraber KH, Rall SC, Hui DY, Lalazar A, Boyles JK, Taylor JM, Levy-Wilson B.  1986.  Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions.. Cold Spring Harb Symp Quant Biol. 51 Pt 2:821-8.
Cornhill JF, Barrett WA, Herderick EE, Mahley RW, Fry DL.  1985.  Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis.. Arteriosclerosis. 5(5):415-26.
Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM.  1985.  Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.. J Clin Invest. 76(4):1501-13.
Paik YK, Chang DJ, Reardon CA, Davies GE, Mahley RW, Taylor JM.  1985.  Nucleotide sequence and structure of the human apolipoprotein E gene.. Proc Natl Acad Sci U S A. 82(10):3445-9.
Pitas RE, Boyles J, Mahley RW, Bissell DM.  1985.  Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.. J Cell Biol. 100(1):103-17.
Weisgraber KH, Newhouse YM, Seymour JL, Rall SC, Mahley RW.  1985.  Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels.. Anal Biochem. 151(2):455-61.
Weisgraber KH, Innerarity TL, Rall SC, Mahley RW.  1985.  Receptor interactions controlling lipoprotein metabolism.. Can J Biochem Cell Biol. 63(8):898-905.
Weisgraber KH, Innerarity TL, Rall SC, Mahley RW.  1985.  Apolipoprotein E: receptor binding properties.. Adv Exp Med Biol. 183:159-71.
Mahley RW, Innerarity TL, Rall SC, Weisgraber KH.  1985.  Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia.. Ann N Y Acad Sci. 454:209-21.
Funke H, Boyles J, Weisgraber KH, Ludwig EH, Hui DY, Mahley RW.  1984.  Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells.. Arteriosclerosis. 4(5):452-61.
Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL.  1984.  Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia.. Proc Natl Acad Sci U S A. 81(17):5566-70.
Utermann G, Haas J, Steinmetz A, Paetzold R, Rall SC, Weisgraber KH, Mahley RW.  1984.  Apolipoprotein A-IGiessen (Pro143----Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase.. Eur J Biochem. 144(2):325-31.
McLean JW, Elshourbagy NA, Chang DJ, Mahley RW, Taylor JM.  1984.  Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.. J Biol Chem. 259(10):6498-504.
Menzel HJ, Assmann G, Rall SC, Weisgraber KH, Mahley RW.  1984.  Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type.. J Biol Chem. 259(5):3070-6.
Innerarity TL, Weisgraber KH, Arnold KS, Rall SC, Mahley RW.  1984.  Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.. J Biol Chem. 259(11):7261-7.
Innerarity TL, Bersot TP, Arnold KS, Weisgraber KH, Davis PA, Forte TM, Mahley RW.  1984.  Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma.. Metabolism. 33(2):186-95.
Mahley RW, Innerarity TL, Rall SC, Weisgraber KH.  1984.  Plasma lipoproteins: apolipoprotein structure and function.. J Lipid Res. 25(12):1277-94.
Rall SC, Weisgraber KH, Mahley RW, Ogawa Y, Fielding CJ, Utermann G, Haas J, Steinmetz A, Menzel HJ, Assmann G.  1984.  Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.. J Biol Chem. 259(16):10063-70.
Weisgraber KH, Rall SC, Innerarity TL, Mahley RW, Kuusi T, Ehnholm C.  1984.  A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1.. J Clin Invest. 73(4):1024-33.
Steinmetz A, Utermann G, Haas J, Menzel HJ, Rall SC, Weisgraber KH, Mahley RW.  1984.  Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase.. Agents Actions Suppl. 16:217-24.
Innerarity TL, Friedlander EJ, Rall SC, Weisgraber KH, Mahley RW.  1983.  The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.. J Biol Chem. 258(20):12341-7.
Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT.  1983.  The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.. J Biol Chem. 258(20):12348-54.
Schmitz G, Assmann G, Rall SC, Mahley RW.  1983.  Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-i) with high density lipoproteins.. Proc Natl Acad Sci U S A. 80(19):6081-5.
Rall SC, Weisgraber KH, Innerarity TL, Bersot TP, Mahley RW, Blum CB.  1983.  Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.. J Clin Invest. 72(4):1288-97.
Gordon V, Innerarity TL, Mahley RW.  1983.  Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro.. J Biol Chem. 258(10):6202-12.
Mahley RW, Innerarity TL.  1983.  Lipoprotein receptors and cholesterol homeostasis.. Biochim Biophys Acta. 737(2):197-222.
Mahley RW.  1983.  Apolipoprotein E and cholesterol metabolism.. Klin Wochenschr. 61(5):225-32.
Rouleau JL, Parmley WW, Stevens J, Wikman-Coffelt J, Sievers R, Mahley RW, Havel RJ.  1983.  Verapamil suppresses atherosclerosis in cholesterol-fed rabbits.. J Am Coll Cardiol. 1(6):1453-60.
Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR.  1983.  Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I.. J Biol Chem. 258(4):2508-13.
Rall SC, Weisgraber KH, Innerarity TL, Mahley RW.  1983.  Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.. J Clin Invest. 71(4):1023-31.
Reitman JS, Mahley RW, Fry DL.  1982.  Yucatan miniature swine as a model for diet-induced atherosclerosis.. Atherosclerosis. 43(1):119-32.
Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR et al..  1982.  Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.. J Lipid Res. 23(6):911-4.
Rall SC, Weisgraber KH, Innerarity TL, Mahley RW.  1982.  Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.. Proc Natl Acad Sci U S A. 79(15):4696-700.
Rall SC, Weisgraber KH, Mahley RW.  1982.  Human apolipoprotein E. The complete amino acid sequence.. J Biol Chem. 257(8):4171-8.
Weisgraber KH, Rall SC, Mahley RW.  1981.  Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.. J Biol Chem. 256(17):9077-83.
Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL et al..  1981.  Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.. J Clin Invest. 68(4):1075-85.
Mahley RW, Hui DY, Innerarity TL, Weisgraber KH.  1981.  Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.. J Clin Invest. 68(5):1197-206.
Pitas RE, Innerarity TL, Weinstein JN, Mahley RW.  1981.  Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy.. Arteriosclerosis. 1(3):177-85.
Melchior GW, Mahley RW, Buckhold DK.  1981.  Chylomicron metabolism during dietary-induced hypercholesterolemia in dogs.. J Lipid Res. 22(4):598-609.
Hui DY, Innerarity TL, Mahley RW.  1981.  Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.. J Biol Chem. 256(11):5646-55.
Innerarity TL, Kempner ES, Hui DY, Mahley RW.  1981.  Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites.. Proc Natl Acad Sci U S A. 78(7):4378-82.
Fry DL, Mahley RW, Oh SY, Swyt CR.  1981.  Aortic transmural serum protein transport: effect of concentration, time, and location.. Am J Physiol. 240(1):H54-61.
Fry DL, Mahley RW, Oh SY.  1981.  Effect of arterial stretch on transmural albumin and Evan's blue dye transport.. Am J Physiol. 240(4):H645-9.
Mahley RW.  1981.  Cellular and molecular biology of lipoprotein metabolism in atherosclerosis.. Diabetes. 30(Suppl 2):60-5.
Weisgraber KH, Bersot TP, Mahley RW, Franceschini G, Sirtori CR.  1980.  A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins.. J Clin Invest. 66(5):901-7.
Mahley RW, Innerarity TL, Brown MS, Ho YK, Goldstein JL.  1980.  Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species.. J Lipid Res. 21(8):970-80.
Weisgraber KH, Mahley RW.  1980.  Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography.. J Lipid Res. 21(3):316-25.
Weisgraber KH, Troxler RF, Rall SC, Mahley RW.  1980.  Comparison of the human, canine and swine E apoproteins.. Biochem Biophys Res Commun. 95(1):374-80.
Mahley RW, Weisgraber KH, Melchior GW, Innerarity TL, Holcombe KS.  1980.  Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.. Proc Natl Acad Sci U S A. 77(1):225-9.
Mahley RW, Johnson DK, Pucak GJ, Fry DL.  1980.  Atherosclerosis in the Erythrocebus patas, an old world monkey.. Am J Pathol. 98(2):401-24.
Hui DY, Harmony JA, Innerarity TL, Mahley RW.  1980.  Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.. J Biol Chem. 255(24):11775-81.
Fry DL, Mahley RW, Oh SY, Lewis SJ, Plowman F, Swyt CR.  1980.  Quantitative microautoradiography of arteries: comparison of radioactivity to silver.. Am J Physiol. 239(2):H289-95.
Mahley RW, Innerarity TL, Weisgraber KH.  1980.  Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins.. Ann N Y Acad Sci. 348:265-80.
Mahley RW, Weisgraber KH, Innerarity TL.  1979.  Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors.. Biochim Biophys Acta. 575(1):81-91.
Pitas RE, Nelson GJ, Jaffe RM, Mahley RW.  1979.  Effects of diets high in saturated fat and cholesterol on the lipid composition of canine platelets.. Lipids. 14(5):469-77.
Reitman JS, Mahley RW.  1979.  Changes induced in the lipoproteins of Yucatan miniature swine by cholesterol feeding.. Biochim Biophys Acta. 575(3):446-57.
Mahley RW, Innerarity TL, Bersot TP, Lipson A, Margolis S.  1978.  Alterations in human high-density lipoproteins, with or without increased plasma-cholesterol, induced by diets high in cholesterol.. Lancet. 2(8094):807-9.
Weisgraber KH, Innerarity TL, Mahley RW.  1978.  Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.. J Biol Chem. 253(24):9053-62.
Tall AR, Atkinson D, Small DM, Mahley RW.  1977.  Characterization of the lipoproteins of atherosclerotic swine.. J Biol Chem. 252(20):7288-93.
Mahley RW, Innerarity TL, Pitas RE, Weisgraber KH, Brown JH, Gross E.  1977.  Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.. J Biol Chem. 252(20):7279-87.
Mahley RW, Holcombe KS.  1977.  Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat.. J Lipid Res. 18(3):314-24.
Fry DL, Mahley RW, Weisgraber KH, Oh SY.  1977.  Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall.. Am J Physiol. 233(1):H66-79.
Mahley RW, Innerarity TL, Weisgraber KH, Fry DL.  1977.  Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.. Am J Pathol. 87(1):205-26.
Mahley RW, Weisgraber KH, Innerarity T, Brewer HB.  1976.  Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey.. Biochemistry. 15(9):1928-33.
Mahley RW, Nelson AW, Ferrans VJ, Fry DL.  1976.  Thrombosis in association with atherosclerosis induced by dietary perturbations in dogs.. Science. 192(4244):1139-41.
Mahley RW, Weisgraber KH, Innerarity T.  1976.  Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey.. Biochemistry. 15(14):2979-85.
Bersot TP, Mahley RW, Brown MS, Goldstein JL.  1976.  Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.. J Biol Chem. 251(8):2395-8.
Mahley RW, Weisgraber KH, Innerarity T, Brewer HB, Assmann G.  1975.  Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding.. Biochemistry. 14(13):2817-23.
Mahley RW, Weisgraber KH.  1974.  An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins.. Biochemistry. 13(9):1964-9.
Assmann G, Mahley RW, Davis B, Holcombe KS.  1974.  Cholesterol esterification by the rat liver Golgi apparatus.. Scand J Clin Lab Invest Suppl. 137:23-8.
Mahley RW, Gray ME, LeQuire VS.  1972.  Role of plasma lipoproteins in cortisone-induced fat embolism.. Am J Pathol. 66(1):43-64.
Mahley RW, Bennett BD, Morré DJ, Gray ME, Thistlethwaite W, LeQuire VS.  1971.  Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine.. Lab Invest. 25(5):435-44.
Morré DJ, Hamilton RL, Mollenhauer HH, Mahley RW, Cunningham WP, Cheetham RD, LeQuire VS.  1970.  Isolation of a Golgi apparatus-rich fraction from rat liver. I. Method and morphology.. J Cell Biol. 44(3):484-91.
Mahley RW, Bersot TP, LeQuire VS, Levy RI, Windmueller HG, Brown WV.  1970.  Identity of very low density lipoprotein apoproteins of plasma and liver Golgi apparatus.. Science. 168(3929):380-2.
Engel E, Culbertson JC, Mahley RW, Fenichel GM.  1970.  Barr body studies from the hair.. Lancet. 1(7650):789.
Mahley RW, Hamilton RL, LeQuire VS.  1969.  Characterization of lipoprotein particles isolated from the Golgi apparatus of rat liver.. J Lipid Res. 10(4):433-9.

Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW. Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function. J Alzheimers Dis. 2019; 68(3):991-1011.

Mahley RW. Apolipoprotein E: Remarkable Protein Sheds Light on Cardiovascular and Neurological Diseases. Clin Chem. 2017 01; 63(1):14-20.

Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538(7624):201-206.

Mahley RW. Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. J Mol Med (Berl). 2016 07; 94(7):739-46.

Mahley RW. Central Nervous System Lipoproteins: ApoE and Regulation of Cholesterol Metabolism. Arterioscler Thromb Vasc Biol. 2016 07; 36(7):1305-15.

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Huang Y, Mahley RW. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiol Dis. 2014 Dec; 72 Pt A:3-12.

Mahley RW. Shinya Yamanaka, M.D., Ph.D. - 2012 Nobel Prize Laureate: how his dream of a research career provides vision for the next generation of young scientists. Anadolu Kardiyol Derg. 2013 May; 13(3):204-6.

Mahley RW, Huang Y. Apolipoprotein e sets the stage: response to injury triggers neuropathology. Neuron. 2012 Dec 06; 76(5):871-85.

Mahley RW, Huang Y. Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology. J Med Chem. 2012 Nov 08; 55(21):8997-9008.

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Hodoglugil U, Mahley RW. Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations. Ann Hum Genet. 2012 Mar; 76(2):128-41.

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Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17; 287(8):5253-66.

Hodoglugil U, Williamson DW, Yu Y, Farrer LA, Mahley RW. Glucuronic acid epimerase is associated with plasma triglyceride and high-density lipoprotein cholesterol levels in Turks. Ann Hum Genet. 2011 May; 75(3):398-417.

Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13; 286(19):17217-26.

Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem. 2011 Feb 18; 286(7):5215-21.

Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S, Aulchenko YS, Zhang W, Yuan X, Lim N, Luan J, Ashford S, Wheeler E, Young EH, Hadley D, Thompson JR, Braund PS, Johnson T, Struchalin M, Surakka I, Luben R, Khaw KT, Rodwell SA, Loos RJ, Boekholdt SM, Inouye M, Deloukas P, Elliott P, Schlessinger D, Sanna S, Scuteri A, Jackson A, Mohlke KL, Tuomilehto J, Roberts R, Stewart A, Kesäniemi YA, Mahley RW, Grundy SM, McArdle W, Cardon L, Waeber G, Vollenweider P, Chambers JC, Boehnke M, Abecasis GR, Salomaa V, Järvelin MR, Ruokonen A, Barroso I, Epstein SE, Hakonarson HH, Rader DJ, Reilly MP, Witteman JC, Hall AS, Samani NJ, Strachan DP, Barter P, van Duijn CM, Kooner JS, Peltonen L, Wareham NJ, McPherson R, Mooser V, Sandhu MS. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2264-76.

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Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JR, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day IN, de Geus EJ, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen AL, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PR, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurethsson G, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WH, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, Barroso I. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Feb; 42(2):105-16.

Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, Langenberg C, Prokopenko I, Saxena R, Sladek R, Aulchenko Y, Evans D, Waeber G, Erdmann J, Burnett MS, Sattar N, Devaney J, Willenborg C, Hingorani A, Witteman JC, Vollenweider P, Glaser B, Hengstenberg C, Ferrucci L, Melzer D, Stark K, Deanfield J, Winogradow J, Grassl M, Hall AS, Egan JM, Thompson JR, Ricketts SL, König IR, Reinhard W, Grundy S, Wichmann HE, Barter P, Mahley R, Kesaniemi YA, Rader DJ, Reilly MP, Epstein SE, Stewart AF, Van Duijn CM, Schunkert H, Burling K, Deloukas P, Pastinen T, Samani NJ, McPherson R, Davey Smith G, Frayling TM, Wareham NJ, Meigs JB, Mooser V, Spector TD. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec; 5(12):e1000768.

Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell. 2009 Dec 04; 5(6):634-45.

Hodoglugil U, Williamson DW, Mahley RW. Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population. J Lipid Res. 2010 Feb; 51(2):422-30.

Mahley RW, Huang Y. Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches. Ann Neurol. 2009 Jun; 65(6):623-5.

Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Cohen JC, Grundy SM, Mooser VE, Mitchell BD. Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring). 2009 Apr; 17(4):737-44.

Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res. 2009 Apr; 50 Suppl:S183-8.

Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID. Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population. Obesity (Silver Spring). 2008 Nov; 16(11):2468-71.

Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-88.

Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23.

Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X, Johnson T, Ashford S, Inouye M, Luben R, Sims M, Hadley D, McArdle W, Barter P, Kesäniemi YA, Mahley RW, McPherson R, Grundy SM, Bingham SA, Khaw KT, Loos RJ, Waeber G, Barroso I, Strachan DP, Deloukas P, Vollenweider P, Wareham NJ, Mooser V. LDL-cholesterol concentrations: a genome-wide association study. Lancet. 2008 Feb 09; 371(9611):483-91.

Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1343-6.

Mahley RW, Huang Y, Weisgraber KH. Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease. Curr Alzheimer Res. 2007 Dec; 4(5):537-40.

Stirnadel H, Lin X, Ling H, Song K, Barter P, Kesäniemi YA, Mahley R, McPherson R, Waeber G, Bersot T, Cohen J, Grundy S, Mitchell B, Mooser V, Waterworth D. Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study. Atherosclerosis. 2008 Apr; 197(2):868-76.

Barter P, McPherson YR, Song K, Kesäniemi YA, Mahley R, Waeber G, Bersot T, Mooser V, Waterworth D, Grundy SM. Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia. J Clin Endocrinol Metab. 2007 Jun; 92(6):2041-5.

Mahley RW, Huang Y. Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing. J Clin Invest. 2007 Jan; 117(1):94-8.

Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB. Human prions and plasma lipoproteins. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11312-7.

Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW. Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J. 2007 Feb; 7(1):10-28.

Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y. Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci. 2006 May 10; 26(19):4985-94.

Mahley RW, Huang Y, Weisgraber KH. Putting cholesterol in its place: apoE and reverse cholesterol transport. J Clin Invest. 2006 May; 116(5):1226-9.

Huang Y, Mahley RW. Commentary on "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis. Alzheimers Dement. 2006 Apr; 2(2):71-3.

Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5644-51.

Mahley RW, Bersot TP. High density lipoprotein cholesterol in coronary artery patients: is it as low as expected? Anadolu Kardiyol Derg. 2006 Mar; 6(1):94-6; author reply 96.

Hodoglugil U, Mahley RW. Smoking and obesity make a bad problem worse: genetics and lifestyle affect high density lipoprotein levels in Turks. Anadolu Kardiyol Derg. 2006 Mar; 6(1):60-7.

Mahley RW, Huang Y. Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl. 2006; 185:8-14.

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18700-5.

Chang S, ran Ma T, Miranda RD, Balestra ME, Mahley RW, Huang Y. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18694-9.

Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW. Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration. J Biol Chem. 2006 Feb 03; 281(5):2683-92.

Hodoglugil U, Tanyolaç S, Williamson DW, Huang Y, Mahley RW. Apolipoprotein A-V: a potential modulator of plasma triglyceride levels in Turks. J Lipid Res. 2006 Jan; 47(1):144-53.

Mahley RW, Can S, Ozbayrakçi S, Bersot TP, Tanir S, Palaoglu KE, Pépin GM. Modulation of high-density lipoproteins in a population in istanbul, Turkey, with low levels of high-density lipoproteins. Am J Cardiol. 2005 Aug 15; 96(4):547-55.

Hodoglugil U, Williamson DW, Huang Y, Mahley RW. An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks. Clin Genet. 2005 Aug; 68(2):118-27.

Yu Y, Wyszynski DF, Waterworth DM, Wilton SD, Barter PJ, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Ma Q, Sharma SS, Montgomery DS, Middleton LT, Sundseth SS, Mooser V, Grundy SM, Farrer LA. Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. J Lipid Res. 2005 Oct; 46(10):2202-13.

Hodoglugil U, Williamson DW, Huang Y, Mahley RW. Common polymorphisms of ATP binding cassette transporter A1, including a functional promoter polymorphism, associated with plasma high density lipoprotein cholesterol levels in Turks. Atherosclerosis. 2005 Dec; 183(2):199-212.

Wyszynski DF, Waterworth DM, Barter PJ, Cohen J, Kesäniemi YA, Mahley RW, McPherson R, Waeber G, Bersot TP, Sharma SS, Nolan V, Middleton LT, Sundseth SS, Farrer LA, Mooser V, Grundy SM. Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project). Am J Cardiol. 2005 Jan 15; 95(2):194-8.

Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem. 2004 Oct 22; 279(43):44795-801.

Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J Biol Chem. 2004 Jun 11; 279(24):25511-6.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci. 2004 Mar 10; 24(10):2527-34.

Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci. 2004; 23(3):189-204.

Bersot TP, Pépin GM, Mahley RW. Risk determination of dyslipidemia in populations characterized by low levels of high-density lipoprotein cholesterol. Am Heart J. 2003 Dec; 146(6):1052-9.

Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y. Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J Biol Chem. 2004 Jan 30; 279(5):3862-8.

Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10966-71.

Bersot TP, Palaoglu KE, Mahley RW. Managing dyslipidemia in Turkey: suggested guidelines for a population characterized by low levels of high density lipoprotein cholesterol. Anadolu Kardiyol Derg. 2002 Dec; 2(4):315-22.

Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV. DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. Clin Genet. 2002 Jul; 62(1):68-73.

Shohet RV, Vega GL, Bersot TP, Mahley RW, Grundy SM, Guerra R, Cohen JC. Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC). Hum Mutat. 2002 May; 19(5):536-42.

Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem. 2002 Jun 14; 277(24):21821-8.

Mahley RW, Arslan P, Pekcan G, Pépin GM, Agaçdiken A, Karaagoglu N, Rakicioglu N, Nursal B, Dayanikli P, Palaoglu KE, Bersot TP. Plasma lipids in Turkish children: impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL. J Lipid Res. 2001 Dec; 42(12):1996-2006.

Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8838-43.

Dichek HL, Johnson SM, Akeefe H, Lo GT, Sage E, Yap CE, Mahley RW. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J Lipid Res. 2001 Feb; 42(2):201-10.

Nguyen TT, Kruckeberg KE, O'Brien JF, Ji ZS, Karnes PS, Crotty TB, Hay ID, Mahley RW, O'Brien T. Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (delta149 Leu)]. J Clin Endocrinol Metab. 2000 Nov; 85(11):4354-8.

Mahley RW, Pépin J, Palaoglu KE, Malloy MJ, Kane JP, Bersot TP. Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase. High density lipoprotein characterization and gender-specific effects of apolipoprotein e genotype. J Lipid Res. 2000 Aug; 41(8):1290-301.

Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L. Apolipoprotein E and cognitive performance. Nature. 2000 Mar 23; 404(6776):352-4.

Mahley RW, Rall SC. Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet. 2000; 1:507-37.

Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L. Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience. 2000; 97(2):207-10.

Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A. Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages. J Mol Med (Berl). 2000; 78(4):217-27.

Huang Y, Ji ZS, Brecht WJ, Rall SC, Taylor JM, Mahley RW. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arterioscler Thromb Vasc Biol. 1999 Dec; 19(12):2952-9.

Mahley RW, Huang Y, Rall SC. Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes. J Lipid Res. 1999 Nov; 40(11):1933-49.

Mahley RW, Rall SC. Is epsilon4 the ancestral human apoE allele? Neurobiol Aging. 1999 Jul-Aug; 20(4):429-30.

Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci. 1999 Jun 15; 19(12):4867-80.

Mahley RW, Huang Y. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr Opin Lipidol. 1999 Jun; 10(3):207-17.

Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW, Wieland H, Luley C. Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites. Arterioscler Thromb Vasc Biol. 1999 May; 19(5):1306-15.

Bersot TP, Vega GL, Grundy SM, Palaoglu KE, Atagündüz P, Ozbayrakçi S, Gökdemir O, Mahley RW. Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population. J Lipid Res. 1999 Mar; 40(3):432-8.

Mahley RW, Ji ZS. Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J Lipid Res. 1999 Jan; 40(1):1-16.

Huang Y, Liu XQ, Rall SC, Taylor JM, von Eckardstein A, Assmann G, Mahley RW. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem. 1998 Oct 09; 273(41):26388-93.

Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10914-9.

Huang Y, Liu XQ, Rall SC, Mahley RW. Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J Biol Chem. 1998 Jul 10; 273(28):17483-90.

Vega GL, Gao J, Bersot TP, Mahley RW, Verstraete R, Grundy SM, White A, Cohen JC. The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity. J Lipid Res. 1998 Jul; 39(7):1520-4.

Zhu Y, Bellosta S, Langer C, Bernini F, Pitas RE, Mahley RW, Assmann G, von Eckardstein A. Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7585-90.

Ji ZS, Pitas RE, Mahley RW. Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than e4. J Biol Chem. 1998 May 29; 273(22):13452-60.

Fan J, Ji ZS, Huang Y, de Silva H, Sanan D, Mahley RW, Innerarity TL, Taylor JM. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J Clin Invest. 1998 May 15; 101(10):2151-64.

Pitas RE, Ji ZS, Weisgraber KH, Mahley RW. Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E. Biochem Soc Trans. 1998 May; 26(2):257-62.

Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J Biol Chem. 1998 Jan 23; 273(4):1896-903.

Ji ZS, Dichek HL, Miranda RD, Mahley RW. Heparan sulfate proteoglycans participate in hepatic lipaseand apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J Biol Chem. 1997 Dec 12; 272(50):31285-92.

Huang Y, Rall SC, Mahley RW. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):2817-24.

Huang Y, Schwendner SW, Rall SC, Sanan DA, Mahley RW. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J Biol Chem. 1997 Sep 05; 272(36):22685-94.

Mahley RW. The J. David Gladstone Institutes. Mol Med. 1997 Sep; 3(9):569-71.

Hussain MM, Goldberg IJ, Weisgraber KH, Mahley RW, Innerarity TL. Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity. Arterioscler Thromb Vasc Biol. 1997 Jul; 17(7):1407-13.

McGeer PL, Walker DG, Pitas RE, Mahley RW, McGeer EG. Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro. Brain Res. 1997 Feb 21; 749(1):135-8.

Huang Y, Schwendner SW, Rall SC, Mahley RW. Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J Biol Chem. 1996 Nov 15; 271(46):29146-51.

Weisgraber KH, Mahley RW. Human apolipoprotein E: the Alzheimer's disease connection. FASEB J. 1996 Nov; 10(13):1485-94.

Mahley RW. Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer's disease. Isr J Med Sci. 1996 Jun; 32(6):414-29.

Mahley RW, Nathan BP, Pitas RE. Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease. Ann N Y Acad Sci. 1996 Jan 17; 777:139-45.

Bellosta S, Nathan BP, Orth M, Dong LM, Mahley RW, Pitas RE. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem. 1995 Nov 10; 270(45):27063-71.

Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE. Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. J Clin Invest. 1995 Nov; 96(5):2170-9.

Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9480-4.

Nathan BP, Chang KC, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem. 1995 Aug 25; 270(34):19791-9.

Hussain MM, Innerarity TL, Brecht WJ, Mahley RW. Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits. Saturation of the sequestration step of the remnant clearance pathway. J Biol Chem. 1995 Apr 14; 270(15):8578-87.

Mahley RW, Nathan BP, Bellosta S, Pitas RE. Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease. Curr Opin Lipidol. 1995 Apr; 6(2):86-91.

Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V, Onat H, Fulks P, Mahley LL, Vakar F. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res. 1995 Apr; 36(4):839-59.

Ji ZS, Sanan DA, Mahley RW. Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans. J Lipid Res. 1995 Mar; 36(3):583-92.

Ji ZS, Mahley RW. Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG. Arterioscler Thromb. 1994 Dec; 14(12):2025-31.

Fazio S, Sanan DA, Lee YL, Ji ZS, Mahley RW, Rall SC. Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142). Arterioscler Thromb. 1994 Nov; 14(11):1873-9.

Thomas DL, Mahley RW, Badur S, Palaoglu E, Quinn TC. The epidemiology of hepatitis C in Turkey. Infection. 1994 Nov-Dec; 22(6):411-4.

Mahley RW, Ji ZS, Brecht WJ, Miranda RD, He D. Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism. Ann N Y Acad Sci. 1994 Sep 10; 737:39-52.

Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem. 1994 Sep 02; 269(35):22358-65.

Fan J, Wang J, Bensadoun A, Lauer SJ, Dang Q, Mahley RW, Taylor JM. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8724-8.

Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA. Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure. 1994 Aug 15; 2(8):713-8.

Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. J Clin Invest. 1994 Aug; 94(2):860-9.

Lüttmann S, von Eckardstein A, Wei W, Funke H, Köhler E, Mahley RW, Assmann G. Electrophoretic screening for genetic variation in apolipoprotein C-III: identification of a novel apoC-III variant, apoC-III(Asp45-->Asn), in a Turkish patient. J Lipid Res. 1994 Aug; 35(8):1431-40.

de Silva HV, Más-Oliva J, Taylor JM, Mahley RW. Identification of apolipoprotein B-100 low density lipoproteins, apolipoprotein B-48 remnants, and apolipoprotein E-rich high density lipoproteins in the mouse. J Lipid Res. 1994 Jul; 35(7):1297-310.

Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science. 1994 May 06; 264(5160):850-2.

Ji ZS, Lauer SJ, Fazio S, Bensadoun A, Taylor JM, Mahley RW. Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. J Biol Chem. 1994 May 06; 269(18):13429-36.

Ji ZS, Fazio S, Mahley RW. Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia. J Biol Chem. 1994 May 06; 269(18):13421-8.

Ji ZS, Fazio S, Lee YL, Mahley RW. Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J Biol Chem. 1994 Jan 28; 269(4):2764-72.

de Silva HV, Lauer SJ, Wang J, Simonet WS, Weisgraber KH, Mahley RW, Taylor JM. Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. J Biol Chem. 1994 Jan 21; 269(3):2324-35.

Chiesa G, Johnson DF, Yao Z, Innerarity TL, Mahley RW, Young SG, Hammer RH, Hobbs HH. Expression of human apolipoprotein B100 in transgenic mice. Editing of human apolipoprotein B100 mRNA. J Biol Chem. 1993 Nov 15; 268(32):23747-50.

Lund-Katz S, Weisgraber KH, Mahley RW, Phillips MC. Conformation of apolipoprotein E in lipoproteins. J Biol Chem. 1993 Nov 05; 268(31):23008-15.

Bersot TP, Russell SJ, Thatcher SR, Pomernacki NK, Mahley RW, Weisgraber KH, Innerarity TL, Fox CS. A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder. J Lipid Res. 1993 Jul; 34(7):1149-54.

Thomas DL, Mahley RW, Badur S, Palaoglu KE, Quinn TC. Epidemiology of hepatitis E virus infection in Turkey. Lancet. 1993 Jun 19; 341(8860):1561-2.

Ji ZS, Brecht WJ, Miranda RD, Hussain MM, Innerarity TL, Mahley RW. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J Biol Chem. 1993 May 15; 268(14):10160-7.

de Silva HV, Lauer SJ, Mahley RW, Weisgraber KH, Taylor JM. Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice. Biochem Soc Trans. 1993 May; 21(2):483-7.

Schmidt EB, Illingworth DR, Bacon S, Russell SJ, Thatcher SR, Mahley RW, Weisgraber KH. Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100. Metabolism. 1993 Feb; 42(2):137-9.

Schmidt EB, Illingworth DR, Bacon S, Mahley RW, Weisgraber KH. Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100. Atherosclerosis. 1993 Jan 25; 98(2):213-7.

Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE. Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. J Lipid Res. 1992 Nov; 33(11):1677-88.

Rall SC, Mahley RW. The role of apolipoprotein E genetic variants in lipoprotein disorders. J Intern Med. 1992 Jun; 231(6):653-9.

Illingworth DR, Vakar F, Mahley RW, Weisgraber KH. Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100. Lancet. 1992 Mar 07; 339(8793):598-600.

Hussain MM, Maxfield FR, Más-Oliva J, Tabas I, Ji ZS, Innerarity TL, Mahley RW. Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J Biol Chem. 1991 Jul 25; 266(21):13936-40.

Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science. 1991 Jun 28; 252(5014):1817-22.

Mahley RW, Weisgraber KH, Innerarity TL, Rall SC. Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism. JAMA. 1991 Jan 02; 265(1):78-83.

Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS. Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein. J Biol Chem. 1990 Dec 25; 265(36):22453-9.

Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, Grundy SM, Friedl W, Davignon J, McCarthy BJ. Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia. J Lipid Res. 1990 Aug; 31(8):1337-49.

Crook D, Weisgraber KH, Boyles JK, Mahley RW. Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets. Arteriosclerosis. 1990 Jul-Aug; 10(4):633-47.

Crook D, Weisgraber KH, Rall SC, Mahley RW. Isolation and characterization of several plasma apolipoproteins of common marmoset monkey. Arteriosclerosis. 1990 Jul-Aug; 10(4):625-32.

Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem. 1990 Jun 25; 265(18):10771-9.

Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E. Ann N Y Acad Sci. 1990; 598:37-48.

Hussain MM, Mahley RW, Boyles JK, Lindquist PA, Brecht WJ, Innerarity TL. Chylomicron metabolism. Chylomicron uptake by bone marrow in different animal species. J Biol Chem. 1989 Oct 25; 264(30):17931-8.

Steinberg D, Carew TE, Fielding C, Fogelman AM, Mahley RW, Sniderman AD, Zilversmit DB. Lipoproteins and the pathogenesis of atherosclerosis. Circulation. 1989 Sep; 80(3):719-23.

Hussain MM, Mahley RW, Boyles JK, Fainaru M, Brecht WJ, Lindquist PA. Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake. J Biol Chem. 1989 Jun 05; 264(16):9571-82.

Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. J Clin Invest. 1989 Jun; 83(6):2125-30.

Lalazar A, Mahley RW. Human apolipoprotein E. Receptor binding activity of truncated variants with carboxyl-terminal deletions. J Biol Chem. 1989 May 25; 264(15):8447-50.

Rall SC, Newhouse YM, Clarke HR, Weisgraber KH, McCarthy BJ, Mahley RW, Bersot TP. Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant. J Clin Invest. 1989 Apr; 83(4):1095-101.

Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest. 1989 Mar; 83(3):1015-31.

Weisgraber KH, Newhouse YM, Taylor JM, Tuan B, Nestruck AC, Davignon J, Mahley RW. Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes. Arteriosclerosis. 1989 Jan-Feb; 9(1):50-7.

Mahley RW, Hui DY, Innerarity TL, Beisiegel U. Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake. Arteriosclerosis. 1989 Jan-Feb; 9(1 Suppl):I14-8.

Weisgraber KH, Newhouse YM, Mahley RW. Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1212-7.

Weisgraber KH, Innerarity TL, Newhouse YM, Young SG, Arnold KS, Krauss RM, Vega GL, Grundy SM, Mahley RW. Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9758-62.

Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, Shooter EM, Gebicke-Haerter PJ. Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. J Cell Biol. 1988 Sep; 107(3):1207-13.

Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA. Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. J Mol Biol. 1988 Jul 05; 202(1):179-81.

Beisiegel U, Weber W, Havinga JR, Ihrke G, Hui DY, Wernette-Hammond ME, Turck CW, Innerarity TL, Mahley RW. Apolipoprotein E-binding proteins isolated from dog and human liver. Arteriosclerosis. 1988 May-Jun; 8(3):288-97.

Koo C, Wernette-Hammond ME, Garcia Z, Malloy MJ, Uauy R, East C, Bilheimer DW, Mahley RW, Innerarity TL. Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors. J Clin Invest. 1988 May; 81(5):1332-40.

Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988 Apr 29; 240(4852):622-30.

Lalazar A, Weisgraber KH, Rall SC, Giladi H, Innerarity TL, Levanon AZ, Boyles JK, Amit B, Gorecki M, Mahley RW. Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions. J Biol Chem. 1988 Mar 15; 263(8):3542-5.

Fainaru M, Funke H, Boyles JK, Ludwig EH, Innerarity TL, Mahley RW. Metabolism of canine beta-very low density lipoproteins in normal and cholesterol-fed dogs. Arteriosclerosis. 1988 Mar-Apr; 8(2):130-9.

Friedman G, Wernette-Hammond ME, Hui DY, Mahley RW, Innerarity TL. Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells. J Lipid Res. 1987 Dec; 28(12):1482-94.

Corsini A, Spilman CH, Innerarity TL, Arnold KS, Rall SC, Boyles JK, Mahley RW. Receptor binding activity of lipid recombinants of apolipoprotein B-100 thrombolytic fragments. J Lipid Res. 1987 Dec; 28(12):1410-23.

Innerarity TL, Young SG, Poksay KS, Mahley RW, Smith RS, Milne RW, Marcel YL, Weisgraber KH. Structural relationship of human apolipoprotein B48 to apolipoprotein B100. J Clin Invest. 1987 Dec; 80(6):1794-8.

Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, Grundy SM. Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6919-23.

Ludwig EH, Blackhart BD, Pierotti VR, Caiati L, Fortier C, Knott T, Scott J, Mahley RW, Levy-Wilson B, McCarthy BJ. DNA sequence of the human apolipoprotein B gene. DNA. 1987 Aug; 6(4):363-72.

Ignatius MJ, Shooter EM, Pitas RE, Mahley RW. Lipoprotein uptake by neuronal growth cones in vitro. Science. 1987 May 22; 236(4804):959-62.

Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ. Human apolipoprotein B: complete cDNA sequence and identification of structural domains of the protein. Biochem Soc Trans. 1987 Apr; 15(2):195-9.

Marcel YL, Innerarity TL, Spilman C, Mahley RW, Protter AA, Milne RW. Mapping of human apolipoprotein B antigenic determinants. Arteriosclerosis. 1987 Mar-Apr; 7(2):166-75.

Gebicke-Haerter PJ, Darby JK, Shooter EM, Riccardi VM, Weisgraber KH, Boyles JK, Mahley RW. Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. Exp Neurol. 1987 Feb; 95(2):323-35.

Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta. 1987 Jan 13; 917(1):148-61.

Scott J, Pease RJ, Powell LM, Wallis SC, McCarthy BJ, Mahley RW, Levy-Wilson B, Knott TJ. Apolipoprotein B gene: plasma cholesterol and atherosclerosis. Biochem Soc Symp. 1987; 53:155-63.

Innerarity TL, Weisgraber KH, Rall SC, Mahley RW. Functional domains of apolipoprotein E and apolipoprotein B. Acta Med Scand Suppl. 1987; 715:51-9.

Mahley RW. The molecular basis of atherosclerosis: concepts derived from studies of lipoprotein metabolism and cell biology. Clin Invest Med. 1986 Nov; 9(4):304-8.

Knott TJ, Wallis SC, Powell LM, Pease RJ, Lusis AJ, Blackhart B, McCarthy BJ, Mahley RW, Levy-Wilson B, Scott J. Complete cDNA and derived protein sequence of human apolipoprotein B-100. Nucleic Acids Res. 1986 Sep 25; 14(18):7501-3.

Mahley RW, Innerarity TL, Hui DY, Weisgraber KH, Pitas RE. Pathology: plasma cholesterol levels determined by lipoprotein interactions with cell surface receptors. West J Med. 1986 Sep; 145(3):372.

Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM. Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem. 1986 Jul 25; 261(21):9858-64.

Rall SC, Weisgraber KH, Mahley RW, Ehnholm C, Schamaun O, Olaisen B, Blomhoff JP, Teisberg P. Identification of homozygosity for a human apolipoprotein A-I variant. J Lipid Res. 1986 Apr; 27(4):436-41.

Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW. Isolation and characterization of the apolipoprotein E receptor from canine and human liver. J Biol Chem. 1986 Mar 25; 261(9):4256-67.

Weisgraber KH, Rall SC, Mahley RW, Milne RW, Marcel YL, Sparrow JT. Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3. J Biol Chem. 1986 Feb 15; 261(5):2068-76.

Ignatius MJ, Gebicke-Härter PJ, Skene JH, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM. Expression of apolipoprotein E during nerve degeneration and regeneration. Proc Natl Acad Sci U S A. 1986 Feb; 83(4):1125-9.

Bersot TP, Innerarity TL, Pitas RE, Rall SC, Weisgraber KH, Mahley RW. Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages. J Clin Invest. 1986 Feb; 77(2):622-30.

Innerarity TL, Arnold KS, Weisgraber KH, Mahley RW. Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages. Arteriosclerosis. 1986 Jan-Feb; 6(1):114-22.

Mahley RW, Innerarity TL, Weisgraber KH, Rall SC, Hui DY, Lalazar A, Boyles JK, Taylor JM, Levy-Wilson B. Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:821-8.

Weisgraber KH, Mahley RW. Characterization of apolipoprotein E-containing lipoproteins. Methods Enzymol. 1986; 129:145-66.

Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM. Cloning and expression of the human apolipoprotein E gene. Methods Enzymol. 1986; 128:811-23.

Taylor JM, Mahley RW, Fukazawa C. Cloning of the cDNA for rat and human apolipoprotein E mRNA. Methods Enzymol. 1986; 128:801-11.

Rall SC, Weisgraber KH, Mahley RW. Isolation and characterization of apolipoprotein E. Methods Enzymol. 1986; 128:273-87.

Innerarity TL, Pitas RE, Mahley RW. Lipoprotein-receptor interactions. Methods Enzymol. 1986; 129:542-65.

Innerarity TL, Hui DY, Bersot TP, Mahley RW. Type III hyperlipoproteinemia: a focus on lipoprotein receptor-apolipoprotein E2 interactions. Adv Exp Med Biol. 1986; 201:273-88.

Weisgraber KH, Newhouse YM, Seymour JL, Rall SC, Mahley RW. Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels. Anal Biochem. 1985 Dec; 151(2):455-61.

Mahley RW. Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology. Circulation. 1985 Nov; 72(5):943-8.

Koo C, Innerarity TL, Mahley RW. Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins. J Biol Chem. 1985 Oct 05; 260(22):11934-43.

Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest. 1985 Oct; 76(4):1501-13.

Cornhill JF, Barrett WA, Herderick EE, Mahley RW, Fry DL. Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis. Arteriosclerosis. 1985 Sep-Oct; 5(5):415-26.

Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Receptor interactions controlling lipoprotein metabolism. Can J Biochem Cell Biol. 1985 Aug; 63(8):898-905.

Paik YK, Chang DJ, Reardon CA, Davies GE, Mahley RW, Taylor JM. Nucleotide sequence and structure of the human apolipoprotein E gene. Proc Natl Acad Sci U S A. 1985 May; 82(10):3445-9.

Elshourbagy NA, Liao WS, Mahley RW, Taylor JM. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci U S A. 1985 Jan; 82(1):203-7.

Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Apolipoprotein E: receptor binding properties. Adv Exp Med Biol. 1985; 183:159-71.

Mahley RW, Innerarity TL, Rall SC, Weisgraber KH. Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia. Ann N Y Acad Sci. 1985; 454:209-21.

Pitas RE, Boyles J, Mahley RW, Bissell DM. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol. 1985 Jan; 100(1):103-17.

Hui DY, Innerarity TL, Milne RW, Marcel YL, Mahley RW. Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. A process independent of apolipoprotein B48. J Biol Chem. 1984 Dec 25; 259(24):15060-8.

Mahley RW, Innerarity TL, Rall SC, Weisgraber KH. Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 01; 25(12):1277-94.

Utermann G, Haas J, Steinmetz A, Paetzold R, Rall SC, Weisgraber KH, Mahley RW. Apolipoprotein A-IGiessen (Pro143----Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase. Eur J Biochem. 1984 Oct 15; 144(2):325-31.

Ehnholm C, Mahley RW, Chappell DA, Weisgraber KH, Ludwig E, Witztum JL. Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5566-70.

Funke H, Boyles J, Weisgraber KH, Ludwig EH, Hui DY, Mahley RW. Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells. Arteriosclerosis. 1984 Sep-Oct; 4(5):452-61.

Rall SC, Weisgraber KH, Mahley RW, Ogawa Y, Fielding CJ, Utermann G, Haas J, Steinmetz A, Menzel HJ, Assmann G. Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. J Biol Chem. 1984 Aug 25; 259(16):10063-70.

Innerarity TL, Weisgraber KH, Arnold KS, Rall SC, Mahley RW. Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. J Biol Chem. 1984 Jun 10; 259(11):7261-7.

McLean JW, Elshourbagy NA, Chang DJ, Mahley RW, Taylor JM. Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant. J Biol Chem. 1984 May 25; 259(10):6498-504.

Weisgraber KH, Rall SC, Innerarity TL, Mahley RW, Kuusi T, Ehnholm C. A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1. J Clin Invest. 1984 Apr; 73(4):1024-33.

Utermann G, Weisgraber KH, Weber W, Mahley RW. Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis. J Lipid Res. 1984 Apr; 25(4):378-82.

Menzel HJ, Assmann G, Rall SC, Weisgraber KH, Mahley RW. Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type. J Biol Chem. 1984 Mar 10; 259(5):3070-6.

Innerarity TL, Bersot TP, Arnold KS, Weisgraber KH, Davis PA, Forte TM, Mahley RW. Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma. Metabolism. 1984 Feb; 33(2):186-95.

Hui DY, Innerarity TL, Mahley RW. Defective hepatic lipoprotein receptor binding of beta-very low density lipoproteins from type III hyperlipoproteinemic patients. Importance of apolipoprotein E. J Biol Chem. 1984 Jan 25; 259(2):860-9.

Steinmetz A, Utermann G, Haas J, Menzel HJ, Rall SC, Weisgraber KH, Mahley RW. Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase. Agents Actions Suppl. 1984; 16:217-24.

Mahley RW, Angelin B. Type III hyperlipoproteinemia: recent insights into the genetic defect of familial dysbetalipoproteinemia. Adv Intern Med. 1984; 29:385-411.

Innerarity TL, Friedlander EJ, Rall SC, Weisgraber KH, Mahley RW. The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. J Biol Chem. 1983 Oct 25; 258(20):12341-7.

Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT. The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. J Biol Chem. 1983 Oct 25; 258(20):12348-54.

Rall SC, Weisgraber KH, Innerarity TL, Bersot TP, Mahley RW, Blum CB. Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype. J Clin Invest. 1983 Oct; 72(4):1288-97.

Schmitz G, Assmann G, Rall SC, Mahley RW. Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-i) with high density lipoproteins. Proc Natl Acad Sci U S A. 1983 Oct; 80(19):6081-5.

Bersot TP, Innerarity TL, Mahley RW, Havel RJ. Cholesteryl ester accumulation in mouse peritoneal macrophages induced by beta-migrating very low density lipoproteins from patients with atypical dysbetalipoproteinemia. J Clin Invest. 1983 Sep; 72(3):1024-33.

Mahley RW. Development of accelerated atherosclerosis. Concepts derived from cell biology and animal model studies. Arch Pathol Lab Med. 1983 Aug; 107(8):393-9.

Rouleau JL, Parmley WW, Stevens J, Wikman-Coffelt J, Sievers R, Mahley RW, Havel RJ. Verapamil suppresses atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol. 1983 Jun; 1(6):1453-60.

Gordon V, Innerarity TL, Mahley RW. Formation of cholesterol- and apoprotein E-enriched high density lipoproteins in vitro. J Biol Chem. 1983 May 25; 258(10):6202-12.

Mahley RW, Innerarity TL. Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta. 1983 May 24; 737(2):197-222.

Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia. J Clin Invest. 1983 Apr; 71(4):1023-31.

Angelin B, Raviola CA, Innerarity TL, Mahley RW. Regulation of hepatic lipoprotein receptors in the dog. Rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids. J Clin Invest. 1983 Apr; 71(4):816-31.

Mahley RW. Apolipoprotein E and cholesterol metabolism. Klin Wochenschr. 1983 Mar 01; 61(5):225-32.

Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR. Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I. J Biol Chem. 1983 Feb 25; 258(4):2508-13.

Pitas RE, Innerarity TL, Mahley RW. Foam cells in explants of atherosclerotic rabbit aortas have receptors for beta-very low density lipoproteins and modified low density lipoproteins. Arteriosclerosis. 1983 Jan-Feb; 3(1):2-12.

Zannis VI, Breslow JL, Utermann G, Mahley RW, Weisgraber KH, Havel RJ, Goldstein JL, Brown MS, Schonfeld G, Hazzard WR, Blum C. Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. J Lipid Res. 1982 Aug; 23(6):911-4.

Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proc Natl Acad Sci U S A. 1982 Aug; 79(15):4696-700.

Fainaru M, Mahley RW, Hamilton RL, Innerarity TL. Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia. J Lipid Res. 1982 Jul; 23(5):702-14.

Reitman JS, Mahley RW, Fry DL. Yucatan miniature swine as a model for diet-induced atherosclerosis. Atherosclerosis. 1982 May; 43(1):119-32.

Rall SC, Weisgraber KH, Mahley RW. Human apolipoprotein E. The complete amino acid sequence. J Biol Chem. 1982 Apr 25; 257(8):4171-8.

Weisgraber KH, Innerarity TL, Mahley RW. Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem. 1982 Mar 10; 257(5):2518-21.

Mahley RW. Atherogenic hyperlipoproteinemia. The cellular and molecular biology of plasma lipoproteins altered by dietary fat and cholesterol. Med Clin North Am. 1982 Mar; 66(2):375-402.

Innerarity TL, Pitas RE, Mahley RW. Modulating effects of canine high density lipoproteins on cholesteryl ester synthesis induced by beta-very low density lipoproteins in macrophages. Possible in vitro correlates with atherosclerosis. Arteriosclerosis. 1982 Mar-Apr; 2(2):114-24.

Mahley RW, Hui DY, Innerarity TL, Weisgraber KH. Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. J Clin Invest. 1981 Nov; 68(5):1197-206.

Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW. Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. J Clin Invest. 1981 Oct; 68(4):1075-85.

Weisgraber KH, Rall SC, Mahley RW. Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem. 1981 Sep 10; 256(17):9077-83.

Innerarity TL, Kempner ES, Hui DY, Mahley RW. Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4378-82.

Hui DY, Innerarity TL, Mahley RW. Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors. J Biol Chem. 1981 Jun 10; 256(11):5646-55.

Pitas RE, Innerarity TL, Weinstein JN, Mahley RW. Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis. 1981 May-Jun; 1(3):177-85.

Melchior GW, Mahley RW, Buckhold DK. Chylomicron metabolism during dietary-induced hypercholesterolemia in dogs. J Lipid Res. 1981 May; 22(4):598-609.

Fry DL, Mahley RW, Oh SY. Effect of arterial stretch on transmural albumin and Evan's blue dye transport. Am J Physiol. 1981 Apr; 240(4):H645-9.

Fry DL, Mahley RW, Oh SY, Swyt CR. Aortic transmural serum protein transport: effect of concentration, time, and location. Am J Physiol. 1981 Jan; 240(1):H54-61.

Mahley RW. Cellular and molecular biology of lipoprotein metabolism in atherosclerosis. Diabetes. 1981; 30(Suppl 2):60-5.

Mahley RW. The role of dietary fat and cholesterol in atherosclerosis and lipoprotein metabolism. West J Med. 1981 Jan; 134(1):34-42.

Hui DY, Harmony JA, Innerarity TL, Mahley RW. Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B. J Biol Chem. 1980 Dec 25; 255(24):11775-81.

Innerarity TL, Pitas RE, Mahley RW. Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity. J Biol Chem. 1980 Dec 10; 255(23):11163-72.

Franceschini G, Sirtori CR, Capurso A, Weisgraber KH, Mahley RW. A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. J Clin Invest. 1980 Nov; 66(5):892-900.

Weisgraber KH, Bersot TP, Mahley RW, Franceschini G, Sirtori CR. A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins. J Clin Invest. 1980 Nov; 66(5):901-7.

Mahley RW, Innerarity TL, Brown MS, Ho YK, Goldstein JL. Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species. J Lipid Res. 1980 Nov; 21(8):970-80.

Pitas RE, Nelson GJ, Mahley RW. Effect of cholesterol supplementation of diets of thyroidectomized dogs on the fatty acid composition of erythrocyte phospholipids and plasma phosphatidylcholine. Biochim Biophys Acta. 1980 Sep 08; 619(3):699-704.

Innerarity TL, Pitas RE, Mahley RW. Receptor binding of cholesterol-induced high-density lipoproteins containing predominantly apoprotein E to cultured fibroblasts with mutations at the low-density lipoprotein receptor locus. Biochemistry. 1980 Sep 02; 19(18):4359-65.

Fry DL, Mahley RW, Oh SY, Lewis SJ, Plowman F, Swyt CR. Quantitative microautoradiography of arteries: comparison of radioactivity to silver. Am J Physiol. 1980 Aug; 239(2):H289-95.

Weisgraber KH, Troxler RF, Rall SC, Mahley RW. Comparison of the human, canine and swine E apoproteins. Biochem Biophys Res Commun. 1980 Jul 16; 95(1):374-80.

Pitas RE, Innerarity TL, Mahley RW. Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein. J Biol Chem. 1980 Jun 10; 255(11):5454-60.

Goldstein JL, Ho YK, Brown MS, Innerarity TL, Mahley RW. Cholesteryl ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins. J Biol Chem. 1980 Mar 10; 255(5):1839-48.

Sherrill BC, Innerarity TL, Mahley RW. Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process. J Biol Chem. 1980 Mar 10; 255(5):1804-7.

Weisgraber KH, Mahley RW. Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography. J Lipid Res. 1980 Mar; 21(3):316-25.

Mahley RW, Johnson DK, Pucak GJ, Fry DL. Atherosclerosis in the Erythrocebus patas, an old world monkey. Am J Pathol. 1980 Feb; 98(2):401-24.

Mahley RW, Innerarity TL, Weisgraber KH. Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins. Ann N Y Acad Sci. 1980; 348:265-80.

Mahley RW, Weisgraber KH, Melchior GW, Innerarity TL, Holcombe KS. Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):225-9.

Reitman JS, Mahley RW. Changes induced in the lipoproteins of Yucatan miniature swine by cholesterol feeding. Biochim Biophys Acta. 1979 Dec 18; 575(3):446-57.

Mahley RW, Weisgraber KH, Innerarity TL. Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors. Biochim Biophys Acta. 1979 Oct 26; 575(1):81-91.

Mahley RW, Innerarity TL, Weisgraber KB, Oh SY. Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins. J Clin Invest. 1979 Sep; 64(3):743-50.

Innerarity TL, Pitas RE, Mahley RW. Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem. 1979 May 25; 254(10):4186-90.

Pitas RE, Nelson GJ, Jaffe RM, Mahley RW. Effects of diets high in saturated fat and cholesterol on the lipid composition of canine platelets. Lipids. 1979 May; 14(5):469-77.

Pitas RE, Innerarity TL, Arnold KS, Mahley RW. Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. Proc Natl Acad Sci U S A. 1979 May; 76(5):2311-5.

Mahley RW, Weisgraber KH, Innerarity TL, Windmueller HG. Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1746-50.

Weisgraber KH, Innerarity TL, Mahley RW. Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts. J Biol Chem. 1978 Dec 25; 253(24):9053-62.

Weisgraber KH, Bersot TP, Mahley RW. Isolation and characterization of an apoprotein from the d less than 1.006 lipoproteins of human and canine lymph homologous with the rat A-IV apoprotein. Biochem Biophys Res Commun. 1978 Nov 14; 85(1):287-92.

Mahley RW, Innerarity TL, Bersot TP, Lipson A, Margolis S. Alterations in human high-density lipoproteins, with or without increased plasma-cholesterol, induced by diets high in cholesterol. Lancet. 1978 Oct 14; 2(8094):807-9.

Atkinson D, Tall AR, Small DM, Mahley RW. Structural organization of the lipoprotein HDLc from atherosclerotic swine. Structural features relating the particle surface and core. Biochemistry. 1978 Sep 19; 17(19):3930-3.

Weisgraber KH, Mahley RW. Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem. 1978 Sep 10; 253(17):6281-8.

Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP. Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex. J Biol Chem. 1978 Sep 10; 253(17):6289-95.

Pitas RE, Nelson GJ, Jaffe RM, Mahley RW. delta 15,18-tetracosadienoic acid content of sphingolipids from platelets and erythrocytes of animals fed diets high in saturated or polyunsaturated fats. Lipids. 1978 Aug; 13(8):551-6.

Innerarity TL, Mahley RW. Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins. Biochemistry. 1978 Apr 18; 17(8):1440-7.

Mahley RW, Innerarity TL. Properties of lipoproteins responsible for high affinity binding to cell surface receptors of fibroblasts and smooth muscle cells. Adv Exp Med Biol. 1978; 109:99-127.

Tall AR, Atkinson D, Small DM, Mahley RW. Characterization of the lipoproteins of atherosclerotic swine. J Biol Chem. 1977 Oct 25; 252(20):7288-93.

Mahley RW, Innerarity TL, Pitas RE, Weisgraber KH, Brown JH, Gross E. Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins. J Biol Chem. 1977 Oct 25; 252(20):7279-87.

Weisgraber KH, Mahley RW, Assmann G. The rat arginine-rich apoprotein and its redistribution following injection of iodinated lipoproteins into normal and hypercholesterolemic rats. Atherosclerosis. 1977 Oct; 28(2):121-40.

Fry DL, Mahley RW, Weisgraber KH, Oh SY. Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall. Am J Physiol. 1977 Jul; 233(1):H66-79.

Mahley RW, Innerarity TL. Interaction of canine and swine lipoproteins with the low density lipoprotein receptor of fibroblasts as correlated with heparin/manganese precipitability. J Biol Chem. 1977 Jun 10; 252(11):3980-6.

Mahley RW, Holcombe KS. Alterations of the plasma lipoproteins and apoproteins following cholesterol feeding in the rat. J Lipid Res. 1977 May; 18(3):314-24.

Mahley RW, Innerarity TL, Weisgraber KH, Fry DL. Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro. Am J Pathol. 1977 Apr; 87(1):205-26.

Mahley RW. Lipoproteins and arterial smooth muscle cells: regulation of cellular metabolism by swine lipoproteins. Adv Exp Med Biol. 1977; 82:909-14.

Brown BG, Mahley R, Assmann G. Swine aortic smooth muscle in tissue culture. Some effects of purified swine lipoproteins on cell growth and morphology. Circ Res. 1976 Sep; 39(3):415-24.

Mahley RW, Weisgraber KH, Innerarity T. Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey. Biochemistry. 1976 Jul 13; 15(14):2979-85.

Mahley R, Nelson AW, Ferrans VJ, Fry DL. Thrombosis in association with atherosclerosis induced by dietary perturbations in dogs. Science. 1976 Jun 11; 192(4244):1139-41.

Mahley RW, Weisgraber KH, Innerarity T, Brewer HB. Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey. Biochemistry. 1976 May 04; 15(9):1928-33.

Bersot TP, Mahley RW, Brown MS, Goldstein JL. Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts. J Biol Chem. 1976 Apr 25; 251(8):2395-8.

Mahley RW, Weisgraber KH, Innerarity T, Brewer HB, Assmann G. Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry. 1975 Jul; 14(13):2817-23.

Mahley RW, Weisgraber KH. Canine lipoproteins and atherosclerosis. I. Isolation and characterization of plasma lipoproteins from control dogs. Circ Res. 1974 Nov; 35(5):713-21.

Mahley RW, Weisgraber KH, Innerarity T. Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia. Circ Res. 1974 Nov; 35(5):722-33.

Wetmore S, Mahley RW, Brown WV, Schachter H. Incorporation of sialic acid into sialidase-treated apolipoprotein of human, very low density lipoprotein by a pork liver sialytransferase. Can J Biochem. 1974 Aug; 52(8):654-64.

Mahley RW, Weisgraber KH. An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins. Biochemistry. 1974 Apr 23; 13(9):1964-9.

Assmann G, Mahley RW, Davis B, Holcombe KS. Cholesterol esterification by the rat liver Golgi apparatus. Scand J Clin Lab Invest Suppl. 1974; 137:23-8.

Mahley RW, Gray ME, LeQuire VS. Role of plasma lipoproteins in cortisone-induced fat embolism. Am J Pathol. 1972 Jan; 66(1):43-64.

Mahley RW, Bennett BD, Morré DJ, Gray ME, Thistlethwaite W, LeQuire VS. Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine. Lab Invest. 1971 Nov; 25(5):435-44.

Mahley RW, Bersot TP, LeQuire VS, Levy RI, Windmueller HG, Brown WV. Identity of very low density lipoprotein apoproteins of plasma and liver Golgi apparatus. Science. 1970 Apr 17; 168(3929):380-2.

Engel E, Culbertson JC, Mahley RW, Fenichel GM. Barr body studies from the hair. Lancet. 1970 Apr 11; 1(7650):789.

Morré DJ, Hamilton RL, Mollenhauer HH, Mahley RW, Cunningham WP, Cheetham RD, Lequire VS. Isolation of a Golgi apparatus-rich fraction from rat liver. I. Method and morphology. J Cell Biol. 1970 Mar; 44(3):484-91.

Mahley RW, Hamilton RL, Lequire VS. Characterization of lipoprotein particles isolated from the Golgi apparatus of rat liver. J Lipid Res. 1969 Jul; 10(4):433-9.

Mahley RW, Gray ME, Hamilton RL, LeQuire VS. Lipid transport in liver. II. Electron microscopic and biochemical studies of alterations in lipoprotein transport induced by cortisone in the rabbit. Lab Invest. 1968 Oct; 19(4):358-69.