- Molecular Biology
- University of Basel (Switzerland)
The recent development of RNA-guided immune systems including CRISPR as programmable tools for genome editing and regulation has spurred a revolution in biology by enabling nearly unlimited genetic manipulation, even in previously difficult contexts such as human cells. This has provided unparalleled insight into mammalian biology and revolutionized medical strategies to treat human disease.
Over the last decade, Fellmann’s work has centered on establishing and optimizing RNA‐guided immune systems and applying them to the study of signaling pathways in cancer, with a particular focus on RAS‐mutant tumors. By combining molecular biology and bioengineering, his lab will study the mechanistic interplay between CRISPR‐Cas enzymes and mammalian DNA repair pathways, and use this knowledge to engineer next‐generation approaches for genome manipulation and precision medicine. The team will apply these tools to study the plasticity of cellular signaling networks in RAS‐mutant and TERT promoter-mutant cancer, and build advanced in vivo models of complex human disease, with the ultimate goal of developing innovative therapies for patients