- Society for Neuroscience
Our laboratory seek to understand the neuronal processes underlying cognitive impairments in neurodegenerative disorders, such as Alzheimer’s disease (AD), and in neuropsychiatric conditions associated with abnormal synchronization of neuronal networks, such as schizophrenia, autism, and epilepsy. We aim to identify molecular, circuit, and network mechanisms of cognitive dysfunction and to develop novel therapeutic approaches to restore brain functions in AD and related disorders. To study these complex diseases, my laboratory primarily uses mouse models that recapitulate key aspects of the cognitive dysfunction and pathology of these conditions. We use in vivo physiology in behaving mice, including electroencephalography (EEG), local field potentials (LFP), and single-unit recordings, optogenetic approaches, genetic and pharmacological manipulations, and behavioral testing to dissect network and circuits mechanisms of brain dysfunction in mouse models of AD.