- American Heart Association (Fellow)
Our laboratory focuses on the structure and function of apolipoprotein (apo) E, including its critical role in cholesterol homeostasis, atherosclerosis and neurodegenerative disorders such as Alzheimer's disease and traumatic brain injury. Several areas are under investigation, including:
ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders; small-molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4 on mitochondria and the cytoskeleton; small-molecule protease inhibitors to block the formation of toxic fragments of apoE4;
Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver;
Plasma HDL cholesterol (HDL-C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL-C levels established by the Turkish Heart Study.