- Association of American Physicians
Our laboratory focuses on virus-host cell interactions of two pathogens: the human immunodeficiency virus (HIV-1) and the hepatitis C virus (HCV). Specifically, we are interested in the molecular mechanisms of HIV transcription and latency, the central role of the HIV transactivator Tat and its control of transcription elongation, T cell activation and immune aging. In HCV research, we study the role of lipid droplets as an assembly platform for HCV virions and identify new host-viral protein interactions as potential therapeutic targets in infected liver cells. We recently developed a new focus on the role of reversible protein acetylation in autoimmunity with special emphasis on type I diabetes.