- Director, Hellman Family Foundation Alzheimer’s Disease Research Program
Research in our laboratory focuses on molecular mechanisms of plasticity and neurodegeneration. A long-term goal of our research is to understand how neuronal activity elicits changes in gene expression that are important for learning and memory. Memory disturbances occur in several neurodegenerative diseases, and we have developed models of several of them including Huntington’s disease (HD), Parkinson’s Disease (PD), amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. A better understanding of the mechanisms that control memory formation and neurodegeneration will yield crucial insights into the pathogenesis of neurodegenerative diseases and the memory disorders that often characterize them.