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July 3, 2018
2018 Roddenberry Scholars at Gladstone

The path to medical breakthroughs lies in bold, ambitious science

April 10, 2018
Gladstone scientists Kazutoshi Takahashi and Tim Rand

Researchers at the Gladstone Institutes provide answers to decade-old questions

 

January 18, 2018
Dr. Sheng Ding

Activating a single gene is sufficient to change skin cells into stem cells. [Photo: Gladstone Institutes]

October 10, 2017
Gladstone scientists Li Gan (right) and Chao Wang (left)

Scientists develop a cheaper, quicker, and more reliable stem cell–based technology to facilitate drug discovery

September 21, 2017
Yadong Huang, Senior Investigator at Gladstone

A new center at Gladstone aims to find unforeseen uses for existing drugs

August 2, 2017
Sheng Ding (right) and Tao Xu (left)

The discovery could improve treatments for autoimmune diseases and cancer

May 17, 2017

Gladstone scientists show that a cancer drug is effective in treating common causes of heart failure

April 24, 2017

Gladstone scientists are the first to produce a type of stem cell–derived neuron that could potentially help restore movement

April 14, 2017

Scientists have developed sophisticated models to unravel complex human biology in their pursuit of cures.

March 20, 2017
Gladstone scientists combine expertise in Alzheimer’s research with legacy as leaders in stem cell technology

Gladstone scientists combine expertise in Alzheimer’s research with legacy as leaders in stem cell technology

December 26, 2016
Drs. Finkbeiner and Skibinski

New details learned about a key cellular protein could lead to treatments for neurodegenerative diseases, such as Parkinson’s, Huntington’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS). 

December 15, 2016
Drs. Srivastava and Ang

Research on a gene mutation that causes holes in the hearts of infants revealed insights into how the heart develops and how it stays healthy.

December 6, 2016
Drs. Srivastava, Conklin, Bruneau, Haldar

A new biopharmaceutical company, Tenaya Therapeutics Inc., will build on discoveries in cardiovascular disease research made at the Gladstone Institutes, concentrating on regenerative medicine and drug discovery for heart failure.

October 24, 2016
Drs. Bruce Conklin and Shinya Yamanaka

How do you improve a Nobel Prize-winning discovery? Add a debilitating disease-causing gene mutation.

 

September 1, 2016
Cells edited with CRISPRi

CRISPR has enormous potential to cure intractable diseases. At the Gladstone Institutes, scientists are using the technology to advance scientific knowledge and pursue new therapies for heart disease, HIV, dementia, blindness, and more.

August 15, 2016
Dr. Steve Finkbeiner

Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

August 4, 2016
Josh Zimmerman and Todd McDevitt

With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders.

April 28, 2016
Drs. Huang, Ding, Srivastava

In a major breakthrough, Gladstone scientists transformed skin cells into heart cells and brain cells using a combination of chemicals and without adding external genes to the cells.

April 20, 2016
Drs. Bruce Conklin and Nathaniel Huebsch

Gladstone scientists have invented a new way to create micro heart muscle from stem cells using a unique dog bone dish. The three-dimensional tissue is ideal for disease modeling and drug testing.

March 10, 2016
Drs. Conklin and Mandegar

Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have manipulated the genome of induced pluripotent stem cells for the first time using a variation of the CRISPR system.

March 3, 2016
Heart cells created from ieCPCs

Gladstone scientists have discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease.

February 26, 2016
Dr. Shinya Yamanaka

Ten years ago, Shinya Yamanaka revolutionized biological research with his discovery of how to turn ordinary skin cells into stem cells with just four key genes.

February 24, 2016
Dr. Todd McDevitt

Todd McDevitt has rapidly enchanced how Gladstone thinks about bioengineering and stem cell biology.

January 5, 2016
Dr. Sheng Ding

Scientists at the Gladstone Institutes have successfully converted human skin cells into fully-functional pancreatic cells.

September 3, 2015
Dr. Steven Finkbeiner

Advanced imaging and computational technology facilitate the search for cures.

August 26, 2015
Dr. Sheng Ding

Using his unique chemical cocktail, Gladstone’s Sheng Ding has regenerated the cells that die in paralyzing spinal cord injuries.

August 6, 2015

Discovering the earliest signs of heart development brings us one step closer to our ultimate goal: creating a complete blueprint for building new hearts.

July 14, 2015
Dr. Bruce Conklin

The new system could serve as a drug-screening tool to make pregnancies safer.

June 9, 2015
Dr. Steve Finkbeiner

Revelations about a key cellular pathway have important implications for neurodegenerative diseases like ALS and frontotemporal dementia.

May 12, 2015
Dr. Todd McDevitt

The new strategy is more sustainable and less risky than the current standard therapies.

March 12, 2015
Heart tissue from iPS cells

Scientists have discovered why some heart tissue turns into bone, and they may have learned how to stop it.

February 2, 2015

By helping cells switch their type, we may have discovered a new way to repair damaged hearts, and potentially revolutionize the future of medicine.

Roddenberry Center for Stem Cell Biology and Regenerative Medicine

Gladstone strategically built a diverse community of scientific and clinical experts whose mission is to make ground-breaking scientific discoveries and bring these advances to the clinic.

 

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iPSC Discovery

Shinya Yamanaka’s discovery of induced pluripotent stem (iPS) cells in 2006 fundamentally changed biomedical research. He showed that skin cells can be reprogrammed into stem cells that, like embryonic stem cells, can develop into virtually any cell type in the body.

 

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