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Steve Finkbeiner, MD, PhD
Director and Senior Investigator, Center for Systems and Therapeutics

Other Professional Titles

Director, Taube/Koret Center for Neurodegenerative Disease Research at Gladstone;
Investigator, Roddenberry Stem Cell Center;
Professor, Neurology and Physiology, University of California, San Francisco

Phone

(415) 734-2508

Fax

(415) 355-0824

Assistant

Kelley Nelson
(415) 734-2509

Areas of Investigation

Research in our laboratory focuses on molecular mechanisms of plasticity and neurodegeneration. A long-term goal of our research is to understand how neuronal activity elicits changes in gene expression that are important for learning and memory. Memory disturbances occur in several neurodegenerative diseases, and we have developed models of several of them including Huntington’s disease (HD), Parkinson’s Disease (PD), amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. A better understanding of the mechanisms that control memory formation and neurodegeneration will yield crucial insights into the pathogenesis of neurodegenerative diseases and the memory disorders that often characterize them.

Lab Focus

Which genes are critical for forming memories and how do they do so?
How do genetic mutations in selected genes lead to elective degeneration in certain types of neurons in HD, PD, and ALS?
What are the critical coping mechanisms that brain cells generate to mitigate the effects of genetic mutations that cause neurodegeneration?
With our unique robotic microscope technology, can we identify the major determinants of cell fate during normal development of stem cells and in neurodegenerative disease?
How can we effectively advance the discoveries we make in the laboratory into medicines to help patients?

Achievements

Found that proteins bound to the cytoplasmic portion of one subtype of glutamate receptor, the N-methyl-D-aspartate receptor, play a critical role coupling local calcium influx through the channel to elicit adaptive gene transcription in neurons. This may be a general mechanism by which diverse calcium channels achieve specific and distinct neuronal responses.
Developed primary culture models of activity-dependent gene transcription and of HD. These models faithfully recapitulate critical features of these processes and allow us to test hypotheses about their underlying mechanisms.
Showed that the nucleus is a critical subcellular site in which mutant huntingtin induces neurodegeneration. However, mutant huntingtin need not aggregate into inclusions to induce neurodegeneration.
Developed an automated imaging system that we call a “robotic microscope.” This instrument enables us to track living neurons over long time periods to quickly quantify the adaptive or maladaptive responses of thousands of neurons. Along with special statistical methods, we now have the ability to determine whether and to what extent a variable that is observed on one day can predict the fate of that neuron on another day. This ability will enable us to unravel confounding cause-and-effect mechanisms.

Affiliations

  • Director, Hellman Family Foundation Alzheimer’s Disease Research Program
  • American Neurological Association
  • Society for Neuroscience
  • American Society for Cell Biology
  • Biophysical Society
  • Vertex Pharmaceuticals (Scientific Advisory Board)
  • LINK Medicine (Scientific Advisory Board)
  • FivePrime Therapeutics, Inc. (Consultant)

Professional titles

Director, Taube/Koret Center for Neurodegenerative Disease Research at Gladstone;
Investigator, Roddenberry Stem Cell Center;
Professor, Neurology and Physiology, University of California, San Francisco

Education

1986
BS
  • Wheaton College
1991
MD
  • Yale University
1991
PhD
  • Yale University

Honors and Awards

2011 Award for Outstanding Research Achievement, Nature Biotechnology
2008 Distinguished Leadership Award, Huntington's Disease Society of America
2008 UCSF Annual Outstanding Faculty Mentorship Award, Graduate Student Association, University of California, San Francisco
2005 Therapeutics Initiative Award, Huntington's Disease Society of America
2005 Taube Prize for Outstanding Work on Huntington's Disease
2005 Lieberman Award for Outstanding Work in Huntington's Disease
2001 W.M. Keck Research Excellence Award
2001 Klingenstein Award in Neuroscience
1999 Charles E. Culpepper Medical Scholar Award