Todd McDevitt, PhD
Senior Investigator, Gladstone Institute of Cardiovascular Disease

Other Professional Titles

Professor, University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences

Phone

(415) 734-2875

Fax

(415) 355-0960

Assistant

Sue Cammack
(415) 734-2713

On The Web

Areas of Investigation

We are studying stem cell differentiation and morphogenesis to engineer three-dimensional, multicellular systems that can be used to study principles of stem cell and developmental biology. We are designing many new technologies to better control and assess stem cell phenotypes, with a particular focus on scalable methods and non-destructive analyses that are directly and immediately relevant to biomanufacturing needs. We are creating novel biotherapeutic approaches based on factors derived from stem cells to facilitate regenerative molecular therapies and engineer new platforms that can model and treat a variety of biomedical problems, including cardiovascular disease, neurological and immunological disorders, and traumatic musculoskeletal injuries.

Lab Focus

What are the roles of physical and biochemical factors in the extracellular environment that regulate decisions in stem-cell fate, particularly in 3D environments?
What are the critical mechanisms that regulate differentiation and morphogenesis of embryonic tissues during development, and how can we engineer these processes?
How can we create functional 3D models of human tissues from pluripotent stem cells, such as heart, spinal cord, bone, and cartilage?
How can we engineer technologies to deliver factors secreted from stem cells to regenerate tissue, ameliorate disease, and modulate the inflammatory and immune system?
What tools and technologies do we need to develop that we can directly integrate into bioprocessing systems to manufacture stem cells at high yields?

Achievements

Developed scalable systems to culture homogeneous populations of stem-cell aggregates in 3D
Achieved spatiotemporal control of morphogen presentation from biomaterials incorporated within 3D environments of stem cell aggregates
Created acellular materials derived from differentiating pluripotent stem cells
Generated label-free, highly efficient strategies to separate pluripotent stem cells and differentiated progeny
Established 3D computational models of stem cell differentiation and morphogenesis
Delivered stem cell morphogens from engineered biomaterials to promote healing and regeneration of injured tissues

Affiliations

  • Tissue Engineering & Regenerative Medicine International Society (TERMIS)
  • American Heart Association
  • Society for Biomaterials
  • International Society for Stem Cell Research
  • Biomedical Engineering Society
  • American Chemical Society 

  • Society for Biological Engineers, American Institute of Chemical Engineers
  • Journal of Biomedical Materials Research (Editorial Board)
  • BMC Biotechnology (Editorial Board)
  • Biochemical Engineering Journal (Editorial Board)

Professional titles

Professor, University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences

Education

1997
BS
  • Duke University
2001
PhD
  • University of Washington

Honors and Awards

2014 CIRM Research Leadership Award
2014 American Institute of Medical and Biological Engineering (AIMBE) College of Fellows (Elected)
2014 Top Medical Researcher, Atlanta Business Chronicle
2013 “40 Under 40,” Georgia Trend magazine
2013 Best Advisor Award, Georgia Tech Bioengineering Graduate Program
2013 Carol Ann and David D. Flanagan Professorship
2013 Best of BIOT (invited webinar), American Chemical Society
2011 Most Influential Georgians (Notables), Georgia Trend Magazine
2011 UK-US Collaboration Development Award
2011 “Above and Beyond” (Eagle) Award, Georgia Tech Biomedical Engineering Society
2010 Most Influential Georgians (Notables), Georgia Trend Magazine
2010 Young Investigator Award, Society for Biomaterials
2010 Junior Faculty Outstanding Undergraduate Research Mentor Award, Georgia Tech
2009 Petit Institute Interdisciplinary Research and Education Award
2009 Petit Faculty Fellow, Institute for Bioengineering and Bioscience
2008 UK-US Stem Cell Collaboration Development Award
2004 New Investigator Award, American Heart Association, Council on Basic Cardiovascular Sciences