Areas of Investigation
Shipman’s laboratory is broadly interested in engineering new functions into living cells. Recently, they developed a novel method to record information into the DNA of cells with molecular recording devices. These can be used to better understand the molecular timing of developing systems and to create living molecular diagnostics compatible with long-term monitoring of in vivo physiology.
Shipman’s team also aims to engineer arbitrary neural circuits from the ground up using human stem cell–derived neurons as the building material. From simple circuits, they hope to discover the fundamental molecular rules that govern connectivity in the brain. This understanding will be critical to solving neurodevelopment and neuropsychiatric disease.
Lastly, Shipman’s laboratory is interested in engineering synthetic organelles like mitochondria to extend the capacity of eukaryotic cells. This approach will provide new insight into the fundamental biology of developing systems, and may lead to new methods to treat diseases of degeneration and aging.
- Wesleyan Univertisy
- University of California San Francisco