Saptarsi Haldar, MD
Associate Investigator, Gladstone Institute of Cardiovascular Disease

Other Professional Titles

Associate Professor, Department of Medicine, University of California, San Francisco
Faculty, Cardiovascular Research Institute (CVRI), University of California, San Francisco
Faculty, Biomedical Sciences (BMS) Graduate Program, University of California, San Francisco

Phone

(415) 734-4058

Fax

(415) 355-0960

Assistant

Sue Cammack
(415) 734-2713

On The Web

Areas of Investigation

Our laboratory focuses on understanding gene regulation in the cardiovascular system, skeletal muscle, and other metabolic tissues, with the ultimate goal of finding novel therapeutic strategies to prevent and treat cardio-metabolic and -myopathic diseases.  A major aspect of our work centers around transcriptional and epigenetic control of plasticity in cardiomyocytes, smooth muscle, and skeletal muscle in physiology and disease. To study these pathways, we use a range of in vitro and in vivo approaches, including manipulating genes in mice and leveraging genome-wide analyses and chemical biology. We have made several important observations through our work. For example, we identified that acetyl-lysine “reader” proteins of the BET family play a critical role in cardiac transcription and heart failure pathogenesis. Importantly, we showed that inhibition of BET proteins using a potent and specific small molecule could treat heart failure in animal models. Over the past decade, we have also demonstrated that the zinc finger transcription factor KLF15 functions as a nodal regulator of cardiovascular plasticity and multi-organ metabolic homeostasis. Collectively, our work has led to novel pathophysiologic and therapeutic insights for diseases, such as heart failure, aortic aneurysms, diabetes, and skeletal myopathies. Because epigenetic regulators and chromatin-associated proteins are often tractable drug targets, my laboratory actively seeks to discover new targets and translate our findings into novel therapeutics for cardiovascular disease.

Lab Focus

What are the precise mechanisms by which cells in the cardiovascular system control their gene expression?
Can understanding the molecular mechanisms that govern chromatin state and enhancer plasticity during cellular stress provide new insights into the pathogenesis of cardiovascular and metabolic diseases?
Are there novel components of the gene regulatory machinery that can be targeted in heart failure and other cardiovascular diseases?

Achievements

Discovered that BET bromodomain epigenetic regulators function as critical drivers of heart failure pathogenesis and vascular injury responses that can be pharmacologically targeted in vivo
Identified additional novel epigenetic and transcriptional regulators of cardiac hypertrophy and heart failure pathogenesis
Mapped dynamic genome-wide enhancer landscapes of cardiomyocytes and vascular smooth muscle
Defined the transcription factor KLF15 as a nodal regulator of cardiovascular function and multi-organ metabolic homeostasis
Discovered a major mechanism of action for glucocorticoid hormones in skeletal muscle that have important implications for treatment of muscular dystrophy

Affiliations

  • Sarnoff Cardiovascular Foundation
  • American Heart Association Council on Basic Cardiovascular Sciences

Professional titles

Associate Professor, Department of Medicine, University of California, San Francisco
Faculty, Cardiovascular Research Institute (CVRI), University of California, San Francisco
Faculty, Biomedical Sciences (BMS) Graduate Program, University of California, San Francisco

Education

1995
BS
  • Cornell University
2000
MD
  • John Hopkins University School of Medicine

Honors and Awards

2014 Associate Scientific Advisory Board, Science Translational Medicine
2014 Featured Alumnus Invited Presentation, Sarnoff Cardiovascular Foundation
2013 Hartwell Foundation Individual Biomedical Research Award
2013 NIH Loan Repayment Award
2012 ASCI/AAP Best Research Poster Award (overall winner)
2009 Jeremiah Stamler Distinguished Young Investigator Award
2007 Visconsi Scholar, CWRU School of Medicine
2007 NIH K08 Career Development Award
1998 Stanley J. Sarnoff Fellowship for Cardiovascular Science
1995 Tau Beta Pi, National Engineering Honor Society
1994 George M. Jaffin Research Award in Biomechanics
1993 NASA Award in Biomechanics Research