Nevan Krogan, PhD
Senior Investigator, Gladstone Institute of Data Science and Biotechnology

Other Professional Titles

Professor, Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, UCSF

Phone

(415) 734-2980

Fax

(415) 514-9736

Assistant

Lauren Weiser
(415) 734-4809
Nikki Treacy
(415) 476-6109

Areas of Investigation

The Krogan lab utilizes genetics, proteomics, and computational biology to map both physical and functional interactions and to derive mechanistic insights into how specific pathways, complexes and proteins function in various processes. To help accomplish this, they have created several ‘Cell Mapping Initiatives’ aimed at comprehensively detailing these complex interactions among genes and proteins using a combination of physical interaction, genetic interaction, and computational approaches. They have established numerous collaborations with experts under the umbrella of the Cancer Cell Map Initiative (CCMI), the Psychiatric Cell Mapping Initiative (PCMI) and the Host Pathogen Map Initiative (HPMI). This work will enable them to analyze the molecular networks effected by cancer, psychiatric disorders like Autism, Schizophrenia and Depression, infectious diseases like TB, MRSA, HIV and influenza. The Krogan lab adopts these approaches to study different diseases, with the aim of gaining insight into the molecular mechanisms of health and pathogenesis.

Lab Focus

How do biological networks change under different stress conditions in a given organism and how do they evolve across different species?
What global changes can be seen in post-translational modification in the host proteome infected by HIV?
What genetic interactions exist between RNAi and mutant viruses?
Will hepatitis C, influenza and West Nile virus protein interactions with human proteins reflect similar or differing methods of host infection when compared to HIV?

Achievements

Developed computational and experimental tools for the functional interrogation of different biological systems using protein-protein and genetic interaction mapping approaches
Deepened our understanding of how HIV proteins function during the course of infection by identifying several hundred host-pathogen protein interactions, most of which had not been previously identified.
Uncovered a new subunit of the Vif/Cul5 protein complex, called CBFß, that targets the APOBEC3 family of enzymes, restriction factors that inhibit HIV infection, for ubiquitination and degradation.

Professional titles

Professor, Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, UCSF

Education

1997
BS
  • University of Regina, Canada
2014
PhD
  • University of Toronto, Canada

Honors and Awards

2014 Top 40 Under 40, Cell
2012 Alumni Crowning Achievement Award, University of Regina
2009 Searle Scholar, Searle Foundation
2009 Keck Distinguished Young Scholar, W.M. Keck Foundation
2005 L.W. Macpherson Microbiology Award
2004 Hannah Farkas-Himsley and Alexander Memorial Award
2001 Canadian Institute of Health Research (CIHR) Doctoral Fellowship
1999 PGS-B Award, Natural Sciences and Engineering Research Council
1997 Society of Chemical Industry Merit Award
1995 Canadian Cancer Society Studentship