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The Krogan lab utilizes genetics, proteomics, and computational biology to map both physical and functional interactions and to derive mechanistic insights into how specific pathways, complexes and proteins function in various processes. To help accomplish this, they have created several ‘Cell Mapping Initiatives’ aimed at comprehensively detailing these complex interactions among genes and proteins using a combination of physical interaction, genetic interaction, and computational approaches. They have established numerous collaborations with experts under the umbrella of the Cancer Cell Map Initiative (CCMI), the Psychiatric Cell Mapping Initiative (PCMI) and the Host Pathogen Map Initiative (HPMI). This work will enable them to analyze the molecular networks effected by cancer, psychiatric disorders like Autism, Schizophrenia and Depression, infectious diseases like TB, MRSA, HIV and influenza. The Krogan lab adopts these approaches to study different diseases, with the aim of gaining insight into the molecular mechanisms of health and pathogenesis.
- University of Regina, Canada
- University of Toronto, Canada