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Dr. Ott’s research focuses on two pathogens—human immunodeficiency virus (HIV-1) and hepatitis C virus (HCV)—and how they interact with cells in a host. She studies the molecular mechanisms by which HIV infects and replicates in CD4 T cells, and how it wreaks havoc on part of the body’s immune system. In HCV research, Dr. Ott is examining ways by which HCV viral particles assemble within liver cells—in an attempt to understand the interactions between viral proteins, fat metabolism, and mitochondria in these infected cells.
Dr. Ott joined GIVI in 2002 as a Visiting Investigator, and later became a Staff Research Investigator and then a Senior Investigator. In 1999 and 2000, Dr. Ott was honored with the Young Researcher Award at the European Conference on Experimental AIDS Research. In 2006, she won the Hellman Award, established by F. Warren Hellman at UCSF to support the research of promising assistant professors with the capacity for great distinction in their research. She is also a recipient of the Chancellor’s Award for Public Service with UCSF for her work as founder and co-chair of the student-outreach committee at Gladstone. The committee promotes science education in local schools and specifically targets underserved youth. Dr. Ott is a member of many scientific and professional societies, including the Association of American Physicians. She also serves as a permanent member of the AIDS Molecular Cellular Biology study section at the National Institutes of Health and is a member of scientific advisory boards of several scientific institutions, including the Pette Institute of Virology and the Helmholtz organization in Germany. Prior to joining Gladstone, Dr. Ott started her own research group at the German Cancer Research Center in Heidelberg, Germany.
A native of Germany, Dr. Ott earned an MD from the University of Frankfurt/Main, Germany, and a PhD in molecular medicine from the Picower Graduate School in Manhasset, New York.
Gladstone provides the rich and vibrant research environment critical for the success of our highly collaborative research; we enjoy close and interdisciplinary interactions with our colleagues at Gladstone, UCSF and other Bay Area universities and benefit from the climate of scientific excellence and collegiality here at Gladstone.