Dr. Kasler's research focuses on how epigenetic factors—a type of non-genetic factor that can impact a cell’s genetic makeup early during development—regulate the immune system. Recently, Dr. Kasler found that the epigenetic factor HDAC7 is essential for regulating the development of T cells, a major component of the body’s immune system. He has begun coordinating a large-scale effort to apply his findings on HDAC7 to the problem of Type 1 Diabetes, a life-threatening autoimmune disease that often begins in childhood. Dr. Kasler is currently using mouse models to evaluate the role that HDAC7 and related molecules play in this disease, with the hope of identifying much-needed therapies.
Dr. Kasler has received numerous honors and awards, including the ARCS Foundation Fellowship and the Gladstone Award for Excellence in Scientific Research. He came to Gladstone as a postdoctoral fellow in 2001 in the laboratory of Eric Verdin.
Dr. Kasler completed a bachelor’s degree in biology from Duke University, before earning his PhD in molecular and cellular biology from the University of California, Berkeley.