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Recent Advances

January 28, 2016

SAN FRANCISCO, CA—In a pair of new studies, Gladstone scientists discovered a specific neural circuit that controls walking, and they found that input to this circuit is disrupted in Parkinson’s disease.

January 19, 2016

SAN FRANCISCO, CA—Study seeks to improve translation of Alzheimer’s disease studies with virtual version of the Morris water maze—the most commonly used memory assessment in mice.

January 12, 2016

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells.

November 30, 2015

SAN FRANCISCO, CA—Researchers from the Gladstone Institutes have shown for the first time that the protein BRCA1 is required for normal learning and memory and is depleted by Alzheimer’s disease.

October 9, 2015

SAN FRANCISCO, CA—A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS).

September 21, 2015

SAN FRANCISCO, CA—Scientists from the Gladstone Institutes have discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively reversed tau-related dysfunction in an animal model of frontotemporal dementia (FTD).

September 14, 2015

SAN FRANCISCO, CA—A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria—the brain’s cellular power plants—can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.

July 23, 2015

SAN FRANCISCO, CA—The Gladstone Institutes announces the creation of Cure Network Ventures Inc. and Cure Network Dolby Acceleration Partners, LLC, a business endeavor with Dolby Family Ventures and Evotec AG, which will focus on Alzheimer’s disease.

June 8, 2015

SAN FRANCISCO—Scientists from the Gladstone Institutes and the University of Michigan have identified a cellular mechanism that can be targeted to treat ALS. The researchers revealed that increasing levels of a certain key protein successfully protected against cell death in both genetic and sporadic versions of the disease.

February 10, 2015

SAN FRANCISCO, CA—Scientists from the Gladstone Institutes and the University of California, San Francisco report in the Journal of Neuroscience that raising levels of the life-extending protein klotho can protect against learning and memory deficits in a mouse model of Alzheimer’s disease.

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