SAN FRANCISCO, CA—There is new hope in the fight against Huntington’s disease. Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered how the major genetic risk factor for Alzheimer’s disease causes memory impairment.
SAN FRANCISCO, CA—Scientists have long known that the protein tau is involved in dementia, but how it hinders cognitive function has remained uncertain. In a study published in the journal Neuron, researchers at the Gladstone Institutes reveal how tau disrupts the ability of brain cells to strengthen connections with other brain cells, preventing new memories from forming.
SAN FRANCISCO, CA—In a pair of new studies, Gladstone scientists discovered a specific neural circuit that controls walking, and they found that input to this circuit is disrupted in Parkinson’s disease.
SAN FRANCISCO, CA—Study seeks to improve translation of Alzheimer’s disease studies with virtual version of the Morris water maze—the most commonly used memory assessment in mice.
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells.
SAN FRANCISCO, CA—Researchers from the Gladstone Institutes have shown for the first time that the protein BRCA1 is required for normal learning and memory and is depleted by Alzheimer’s disease.
SAN FRANCISCO, CA—A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS).
SAN FRANCISCO, CA—Scientists from the Gladstone Institutes have discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively reversed tau-related dysfunction in an animal model of frontotemporal dementia (FTD).
SAN FRANCISCO, CA—A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria—the brain’s cellular power plants—can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.