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Recent Advances

April 28, 2016

SAN FRANCISCO, CA—In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.

March 10, 2016

SAN FRANCISCO, CA—Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have modified how the genome of induced pluripotent stem cells (iPSCs) is read for the first time using a variation of the CRISPR-Cas9 system.

February 11, 2016

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo.

January 6, 2016

SAN FRANCISCO, CA—Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human skin cells into fully-functional pancreatic cells.

November 23, 2015

SAN FRANCISCO, CA—Scientists have revealed that glucocorticoids, a class of steroid hormones that are commonly prescribed as drugs, enhance muscle endurance and alleviate muscular dystrophy through activation of the gene KLF15.

July 14, 2015

SAN FRANCISCO, CA—Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug-screening tool to make pregnancies safer.

March 12, 2015

SAN FRANCISCO, CA—Researchers from the Gladstone Institutes have used human cells to discover how blood flow in the heart protects against the hardening of valves in cardiovascular disease.

February 5, 2015

SAN FRANCISCO, CA—One of the most exciting scientific advances made in recent years is CRISPR—the ability to precisely edit the genome of cells. However, although this method has incredible potential, the process is extremely inefficient.

October 21, 2014

SAN FRANCISCO, CA—Deepak Srivastava, MD, the Director of the Gladstone Institute of Cardiovascular Disease and Director of the Roddenberry Center for Stem Cell Biology and Medicine, has been elected to the National Academy of Sciences’ Institute of Medicine (IOM).

February 20, 2014

SAN FRANCISCO, CA—The power of regenerative medicine appears to have turned science fiction into scientific reality—by allowing scientists to transform skin cells into cells that closely resemble beating heart cells.

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