Alexis Komor, PhD
The Komor Lab studies the chemical biology of DNA damage and repair. They focus on the functional investigation of human genetic variation and development of precision genome-editing methodologies using chemical biology. Research is centered around five major pillars:
- Using “nontraditional” genome-editing agents to understand genetic variation
- Functional investigation of mutations in DNA damage repair genes
- Development of new precision genome-editing technologies
- Mechanistic study of “nontraditional” genome-editing tools
- Genome-editing outreach
The long-term goal of the Komor Lab’s research is to combat the variant interpretation problem that looms over the field of precision medicine: There are currently over 685 million human single nucleotide variants identified, and less than 1 percent have a defined clinical interpretation. This issue is particularly endemic to rare genetic variants and those discovered in minoritized populations and indigenous people, highlighting the need for a significant increase in studies that functionally assess human genetic variants in a more equitable manner. They have therefore initiated a research program aimed at developing new laboratory-based strategies and systems to study how mutations in DNA repair genes (their area of expertise) affect enzymatic activity, cellular function, and ultimately human health.
Diversity, Equity, and Inclusion
At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.
We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.