Celebrating the 25th Anniversary of the Gladstone Institute of Neurological Disease
Friday, September 15, 2023

Diseases that affect the brain or other parts of the central nervous system are among the most disabling and complex conditions plaguing humankind. As populations around the world are living longer, neurodegenerative disorders have been rising in prevalence at an unprecedented pace. For 25 years, scientists at the Gladstone Institute of Neurological Disease have been at the forefront of neurological research to better understand and ultimately find effective treatments for disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, and related conditions.

This 1-day symposium will showcase foundational achievements of the past, groundbreaking discoveries of the present, and the exciting future potential of disease-focused neuroscience. It will feature presentations by current investigators, distinguished alumni, and invited panelists from across the Bay Area. 

Gain insights into their transformative studies and innovative technologies, and into the unique strategies they are using to develop novel therapeutic approaches in this rapidly evolving area of biomedicine. 

Program

8:15am Continental Breakfast
9am Embracing Unorthodoxy to Advance Disease-Focused Neuroscience from Molecules and Cells to Networks and Translation
Lennart Mucke, MD, Director and Senior Investigator, Gladstone Institute of Neurological Disease
Joseph B. Martin Distinguished Professor of Neuroscience and Professor of Neurology, UC San Francisco
9:50am Making History with an Eye on the Future
Robert W. Mahley, MD, PhD, Senior Investigator and President Emeritus and Founder, Gladstone Institutes
Professor, Departments of Pathology and Medicine, UC San Francisco
10am Blood Drivers of Neurodegeneration
Katerina Akassoglou, PhD, Senior Investigator, Gladstone Institute of Neurological Disease
Director, Gladstone-UCSF Center for Neurovascular Brain Immunology
Professor of Neurology, UC San Francisco
10:35am Break
10:50am Network Abnormalities and Interneuron Dysfunction in Alzheimer’s Disease
Jorge Palop, PhD, Associate Investigator, Gladstone Institute of Neurological Disease
Associate Professor of Neurology, UC San Francisco
11:25am Circulatory Factors as Regulators of Brain Aging and Disease
Tony Wyss-Coray, PhD, Director, Phil and Penny Knight Initiative for Brain Resilience
D.H. Chen Distinguished Professor of Neurology and Neurological Sciences, Stanford University
12pm Lunch
12:45pm Deconstructing Cellular and Circuit Mechanisms in Epilepsy
Jeanne Paz, PhD, Associate Investigator, Gladstone Institute of Neurological Disease
Associate Professor of Neurology, UC San Francisco
1:20pm Neuroimmune Modulation by Alzheimer’s Disease Risk Factors and Therapeutic Opportunities
Li Gan, PhD, Director, Helen and Robert Appel Alzheimer’s Disease Research Institute
Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases, Weill Cornell Medicine
1:55pm Break
2:10pm Multi-Omic Dissection of Noncoding Genetic Drivers of Neurodegenerative Disease Risk
Ryan Corces, PhD, Assistant Investigator, Gladstone Institute of Neurological Disease
Assistant Professor of Neurology, UC San Francisco
2:45pm Understanding and Targeting Energy Failure
Ken Nakamura, MD, PhD, Associate Investigator, Gladstone Institute of Neurological Disease 
Professor of Neurology, UC San Francisco 
 
Neal Bennett, PhD, Staff Scientist, Nakamura Lab, Gladstone Institute of Neurological Disease
3:20pm Break
3:30pm A 25-Year Journey of Tracing Neuronal ApoE4 in Alzheimer's Disease
Yadong Huang, MD, PhD, Senior Investigator, Gladstone Institute of Neurological Disease
Director, Center for Translational Advancement, Gladstone Institutes
Professor of Neurology and Pathology, UC San Francisco
4:05pm A Central Role for the Brain’s Barriers in Alzheimer’s Disease
Andrew Yang, PhD, Assistant Investigator, Gladstone Institute of Neurological Disease
Assistant Professor of Neurology and Anatomy, UC San Francisco
4:40pm Panel Discussion
Future of Biomedicine and Translational Neurobiology
  • Hana El-Samad, PhD, Senior Vice President and Director of Science Integration, Innovation and Insights, Altos Labs
  • Li Gan, PhD, Director, Helen and Robert Appel Alzheimer’s Disease Research Institute, and Burton P. and Judith B. Resnick Distinguished Professor in Neurodegenerative Diseases, Weill Cornell Medicine
  • Stephen Hauser, MD, Professor of Neurology, and Director, Weill Institute for Neurosciences, UC San Francisco
  • Peter Kotsonis, PhD, Vice Chancellor of Business Development, Innovation and Partnerships, UC San Francisco
  • Bruce Miller, MD, A.W. and Mary Margaret Clausen Distinguished Professor of Neurology and Director, Memory and Aging Center, UC San Francisco
5:25pm Closing Remarks 
S. Andrew Josephson, MD, Chair and Carmen Castro Franceschi and Gladyne K. Mitchell Neurohospitalist Distinguished Professor, Department of Neurology 
Weill Institute for Neurosciences, UC San Francisco

Deepak Srivastava, MD, President, Gladstone Institutes
Professor, Departments of Pediatrics and Biochemistry and Biophysics, UC San Francisco
Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology, UC San Francisco

 

Details

Dates
September 15, 2023
Time
9:00am-6:00pm PDT
Location
Mahley Auditorium
Audience
Gladstone and UCSF, Scientific
Contact(s)





Diversity, Equity, and Inclusion

At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.

We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.