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Science for Admin

Bruce Conklin, MD
“Stem Cells and Genome Surgery”
Monday, February 26, 2018 - 12:00pm to 1:00pm
Room 107A/B

Bruce Conklin
Senior Investigator
Scientific Officer for Technology and Innovation

Conklin focuses on the genetic causes of severe human disease, such as cardiomyopathy and cardiac arrhythmia. He uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell-derived models of disease. These engineered human tissues are leading to safer drugs and better drug therapies. Conklin is also developing methods for therapeutic genome editing in select tissues.

Current projects use human induced pluripotent stem cells to model cardiac, hepatic. and retinal diseases. The Conklin laboratory has recently developed a method that significantly increases the ability of preform scarless single-base genome editing to induce or revert disease mutations. They have also developed CRISPR-inhibition cell lines for high-throughput gene inactivation screens. These studies allow the construction of robust in vitro human disease models and also provide a path towards precision medicine and therapeutic genome editing.

For nearly 25 years, Science for Admin has given Gladstone administrators the opportunity to learn first-hand about the science they enable. View all upcoming Science for Admin Events


Upcoming Events

David Knowles, PhD, Stanford University
“Probabilistic Models of Splicing (Dys)regulation in Human Disease”
Fri, May 25, 2018 - 9:00am
Joanna Wysocka, PhD
“Enhancer Dynamics in Development and Evolution”
Wed, May 30, 2018 - 12:00pm
Neerja Katiyar, Bioinformatics Core
Gladstone Data Sience Training Program
Wed, May 30, 2018 - 2:00pm
Get introduced to network biology studies and Cytoscape concepts.
Tue, Jun 05, 2018 - 1:00pm