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Bruce Conklin, MD
“Stem Cells and Genome Surgery”
Monday, February 26, 2018 - 12:00pm to 1:00pm
Room 107A/B

Bruce Conklin
Senior Investigator
Scientific Officer for Technology and Innovation

Conklin focuses on the genetic causes of severe human disease, such as cardiomyopathy and cardiac arrhythmia. He uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell-derived models of disease. These engineered human tissues are leading to safer drugs and better drug therapies. Conklin is also developing methods for therapeutic genome editing in select tissues.

Current projects use human induced pluripotent stem cells to model cardiac, hepatic. and retinal diseases. The Conklin laboratory has recently developed a method that significantly increases the ability of preform scarless single-base genome editing to induce or revert disease mutations. They have also developed CRISPR-inhibition cell lines for high-throughput gene inactivation screens. These studies allow the construction of robust in vitro human disease models and also provide a path towards precision medicine and therapeutic genome editing.


For nearly 25 years, Science for Admin has given Gladstone administrators the opportunity to learn firsthand about the science they enable. View all upcoming Science for Admin Events

 

Upcoming Events

Quaid Morris, PhD, University of Toronto
“Deciphering Post-Transcriptional Regulation, Computationally”
Mon, Nov 19, 2018 - 12:00pm
“Targeting Bioactive Lipids for Regenerative Engineering and Stem Cell Biomanufacturing”
Edward Botchwey, PhD, Georgia Tech
Mon, Nov 26, 2018 - 3:00pm
Deepak Srivastava, MD
“Convergence of Genetics and Cellular Reprogramming for Human Disease”
Wed, Nov 28, 2018 - 11:00am
Dannie Durand, PhD, Carnegie Mellon Univeristy
“Evolutionary Remodeling of the Sporulation Initiation Pathway in Firmicutes”
Wed, Nov 28, 2018 - 3:00pm