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Neurobiology of Disease—20 Years of Discovery

Neurobiology of Disease
Gladstone Institute of Neurological Disease Anniversary Symposium
Wednesday, November 14, 2018 - 9:00am to Thursday, November 15, 2018 - 5:00pm
Mahley Auditorium

Join us in celebrating the rich, 20-year history of our Gladstone Institute of Neurological Disease during this symposium.


Day 1—Wednesday, November 14, 2018
9:30am Continental Breakfast
10:00am Introduction and Overview, Lennart Mucke
10:30am “Neuronal ApoE4 Expression Resulting in Proteome-Wide Alterations and Compromising Bioenergetic Capacity by Disrupting Mitochondrial Function”
Robert W. Mahley, Gladstone Institutes and UCSF
11:00am “A New Hypothesis for the Initiation and Prevention of Parkinson’s Disease”
Dennis J. Selkoe, Harvard Medical School


Scientific Advisory Board Panel Discussion
Lennart Mucke, Moderator
12:30pm Lunch
1:30pm “How Microglial Dysfunction Contributes to AD and FTD”
Li Gan, Gladstone Institutes and UCSF
2:00pm “Pathophysiology of Tau and Emerging Therapeutic Strategies”
Lennart Mucke, Gladstone Institutes and UCSF
2:30pm “ApoE Genotype-Directed Drug Repurposing for Alzheimer’s Disease”
Yadong Huang, Gladstone Institutes and UCSF
3:00pm Break
3:30pm “Twenty Years Searching for Causes and Treatments for Neurodegenerative Disease at Gladstone”
Steven Finkbeiner, Gladstone Institutes and UCSF
4:00pm “Towards a New Integration of Neurology and Psychiatry”
Joseph B. Martin, Harvard Medical School
4:30pm Poster Session and Reception
6:00pm Adjourn
Day 2—Thursday, November 15, 2018
8:30am Continental Breakfast
9:30am “Cognitive and Circuit Changes in Normal Aging”
Carol A. Barnes, University of Arizona
10:00am “Deconstruction and Control of Epileptic Circuits in Dravet Syndrome”
Jeanne T. Paz, Gladstone Institutes and UCSF
10:30am   Break
11:00am “Interneuron and Network Dysfunction in Alzheimer’s Disease”
Jorge J. Palop, Gladstone Institutes and UCSF
11:30am “Leveraging Brain Rhythms as a Therapeutic Intervention for Neurodegeneration”
Li-Huei Tsai, Picower Institute/MIT
12:00pm Lunch
1:00pm “Understanding and Correcting Energy Failure in Neurodegeneration”
Ken Nakamura, Gladstone Institutes and UCSF
1:30pm “Mitochondria, Dopamine, and Parkinson’s Disease Pathogenesis”
D. James Surmeier, Northwestern University
2:00pm “Basal Ganglia Circuit Dysfunction in Hyperkinetic Movement Disorders”
Anatol C. Kreitzer, Gladstone Institutes and UCSF
2:30pm Break
3:00pm “Neurovascular Interactions: Mechanisms, Imaging, Therapeutics”
Katerina Akassoglou, Gladstone Institutes and UCSF
3:30pm “Microglia during Development and Aging: Antagonistic Pleiotropy?”
Richard Ransohoff, Third Rock Ventures
4:00pm “From Body to Mind: How Blood Proteins Regulate Brain Function”
Tony Wyss-Coray, Stanford University
4:30pm Adjourn

This year, the Gladstone Institute of Neurological Disease celebrates 20 years at the forefront of disease-focused neuroscience. Founded in 1998, the Institute emerged from a joint initiative between Gladstone and UCSF’s Department of Neurology.

Members of the Gladstone and UCSF communities are welcome to attend this celebratory symposium. Speakers from Gladstone and other centers of excellence from across the US will discuss the latest exciting developments in research on important major brain diseases and related fields of neuroscience.

Hosted By: 

Lennart Mucke, Director, Gladstone Institute of Neurological Disease