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Taube/Koret Center for Neurodegenerative Disease Research

In 2009, Gladstone joined forces with Taube Philanthropies and the Koret Foundation to found the Taube/Koret Center for Neurodegenerative Disease Research. The Center focuses on new solutions for overcoming crippling neurodegenerative disorders such as Huntington's Disease, which robs patients of their independence by causing things such as short-term memory loss, involuntary movements of the head and trouble with swallowing. Eventually, fatalities occur from complications such as choking or heart failure. No approved drugs exist to even slow the progression of this relentless disorder.

Gladstone’s Taube/Koret Center plays a vital role in decreasing such human suffering by addressing what is known in the biomedical industry as the valley of death. This is the barren territory that few traverse successfully, as many research institutions fail to move a promising biomedical discovery through all the rigorous tests required before a drug company wants to transform the discovery into a pharmaceutical product to help patients. To help Gladstone discoveries successfully cross through the valley, the Taube/Koret Center subsidizes the myriad of early-stage, de-risking tests necessary to make a drug candidate more attractive to pharmaceutical-industry partners, such as tests that reveal at what concentrations a therapeutic compound becomes efficacious—or toxic. 

The Center is also an example of how Gladstone leverages donations for maximum benefit to patients. Using the inaugural $3.6 million gift from the Koret Foundation and Taube Philanthropies, Gladstone has since attracted an additional $22 million from other sources to advance the Taube/Koret Center's research.