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Center for Cell Circuitry

From tiny viruses to complex organs, circuits are fundamental to biology.  Circuits connect individual molecular components and allow cells to process signals and control decision-making. Therapeutically, cellular circuits have enormous potential; if these circuits can be mapped, we could repair broken circuits that lead to disease and disrupt specialized circuits in viruses and cancers.

The Gladstone Center for Cell Circuitry addresses this fundamental challenge by developing single-cell tools to map how cellular components connect into circuits. The center will develop new single-cell approaches that overcome limitations inherent in traditional techniques—which analyze bulk populations of cells, thereby obscuring individual cell behavior. In particular, the Center for Cell Circuitry will focus on the analysis of single-cell kinetics that are essential for circuit mapping. Ultimately, the center’s goal will be to control these circuits through therapeutic targeting in a variety of biological systems, including cellular reprogramming, neuroscience, cancer, and infectious disease.

The Center for Cell Circuitry is a 10-year initiative, launched in 2017 by Founding Director Leor Weinberger, PhD, senior investigator at Gladstone, William and Ute Bowes Distinguished Investigator, and professor of pharmaceutical chemistry, biochemistry and biophysics at UC San Francisco (UCSF). To connect investigators across disciplines, the center includes investigators from the Gladstone Institutes and UCSF, and is guided by a scientific advisory board composed of international leaders in biomedicine.