Adaptive steps in chemoresistance or metastasis can be conceptualized as cells exploring and climbing the hills of fitness landscapes, such as cell survival or invasiveness as a function of gene expression. Gábor Balazsi will discuss the role of fitness landscapes in chemoresistance and metastatic processes and provide examples of inferring such landscapes with the help of protein distribution–controlling synthetic gene circuits.
The Center for Cell Circuitry Seminar connects investigators across disciplines to develop single-cell tools to map how cellular components connect into circuits. The center aims to develop new single-cell approaches that overcome limitations inherent in traditional techniques that analyze bulk populations of cells, thereby obscuring individual cell behavior.
Diversity, Equity, and Inclusion
At Gladstone, we are committed to providing events and professional development activities that resonate with our community’s diverse members. Our goal is to develop creative programming that encompasses a wide variety of ideas and perspectives to inspire, educate, and engage with everyone within our walls.
We want to effect positive change through our events and activities by providing a platform for discussions on important topics related to increasing diversity and inclusiveness in the sciences.