The San Francisco Business Times published its inaugural Upstart 50 list to showcase the Bay Area’s cutting-edge innovation ecosystem. The Inventor category, in which Deepak Srivastava is honored, celebrates the people behind the companies and technologies that are changing the world.
San Francisco Business Times
The Stem Cellar, CIRM
CIRM, California’s Stem Cell Agency, shares what was learned during the patient advocate event held at Gladstone in September. Among others, speakers Deepak Srivastava and Steve Finkbeiner talked about the progress being made in stem cell research.
Some viral pathogens are becoming appealing drug targets because they modify chromatin and other epigenetic machinery. Melanie Ott explains how epigenetic drugs could be used to lure the HIV virus out of latency in this article featured in The Scientist.
Another story published by The Scientist explores how scientists rely on various methods to culture stem cells without depending on mouse feeder cells. Todd McDevitt explains why he uses suspension culture for industrial-scale, as well as making tissues.
An article in The Atlantic explains how scientists realized that healthy microbiomes, from corals to humans, are similar, but that every unhealthy microbiome is unhealthy in its own way. Gladstone’s Katherine Pollard, an expert on the topic, weighs in.
The science and tech website Futurism features a recent study by Melanie Ott and her team that showed how a drug in cancer clinical trials could eventually be used to treat HIV.
About five years ago, two scientists at the Gladstone Institutes — Robert Mahley and Yadong Huang — had seen enough clinical failures in Alzheimer’s drug research to urge a change in strategy. Out of that work, about three years later, came a stealth biotech in South San Francisco called E-Scape Bio. Endpoints tells the story.
Bloomberg Technology looks at a tiny microscope, created by Silicon Valley startup Inscopix, that can capture video of individual neurons firing in the brain. Anatol Kreitzer explains how his Gladstone laboratory uses the microscope to measure and understand how the brain functions during behavior.
The New York Times
In 2001, President George W. Bush issued an executive order banning federal funding for new sources of stem cells developed from preimplantation human embryos. The action stalled research and discouraged scientists.
Five years later, a Kyoto University scientist, Shinya Yamanaka, and his graduate student, Kazutoshi Takahashi, re-energized the field by devising a technique to “reprogram” any adult cell, such as a skin cell, and coax it back to its earliest “pluripotent” stage. From there it can become any type of cell, from a heart muscle cell to a neuron.
Imagine taking a pill to reverse the damage from a heart attack. Scientists at the Gladstone Institutes have made a breakthrough that could bring that kind of treatment a step closer to reality.