A team of researchers at the Gladstone Institutes has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to reversibly and accurately suppress gene expression in induced pluripotent stem cells (iPSCs) and derivative T cells and heart cells.
Dr. Robert Grant, lead investigator of the iPrEx trial—the first study to show the effectiveness of pre-exposure prophylaxis (PrEP) in preventing HIV—weighs in on a new clinical trial for a small vaginal ring that can protect women from contracting HIV.
A team of researchers at the Gladstone Institutes have manufactured a new type of stem cell that is in between an embryonic stem cell and an adult heart cell. The new technique offers hope for treating heart disease.
Researchers have discovered how to make a remarkable new type of cardiac stem cell that may allow hearts to repair themselves. The new study produced these transplantable cells using a revolutionary new technique, which allowed researchers to temporarily “freeze” a stem cell in its development.
In a step forward for diabetes treatment, scientists successfully converted human skin cells into pancreatic cells that created insulin and protected mice from developing diabetes. The researchers say the findings open the door for disease modeling, drug screening and making personalized cell therapy a step closer for diabetes patients.
Scientists have converted human skin cells into the insulin-producing cells of the pancreas. The development could lead to new treatments for patients with diabetes using tissue transplants derived from their own skin cells.
Scientists have found a way of turning skin cells into healthy pancreatic cells, which could replace those damaged in type 1 diabetes. The breakthrough could spell the end to the grind of insulin injections.
SF Business Times
Scientists at the Gladstone Institutes have reprogrammed human skin cells into insulin-producing cells that may offer a new strategy for attacking Type 1 diabetes.
Researchers at the nonprofit Gladstone Institutes in San Francisco have linked the BRCA1 protein, a product of the BRCA1 gene, to normal learning and memory functions. Moreover, this protein appears to be depleted in the brains of people with Alzheimer’s disease.
The faulty BRCA1 gene, which is associated with breast and ovarian cancer, is linked to Alzheimer's disease, researchers believe. Scientists found that depletion of BRCA1 proteins can result in cognitive problems. They now hope to test whether increasing BRCA1 levels could prevent or reverse neurodegeneration and memory problems.