Mohammad Mandegar, a researcher at the Gladstone Institutes, comments on a study revealing a new CRISPR protein, C2c2, that targets RNA.
To repair cardiac damage after a heart attack, numerous clinical studies have experimented with injecting a variety of potentially therapeutic cells into patients, but very little of the introduced material sticks around. So Sheng Ding of the Gladstone Institutes has been working on another idea: produce progenitor cells that will grow into new heart tissue.
Researchers have developed a method to directly reprogram cells using a combination of nine chemical compounds. The procedure bypasses the induced pluripotency step that has been used in previous chemical methods of cell reprogramming, as well as the gene introduction step that has been a focus of other attempts to reprogram cells directly.
Researchers from the Gladstone Institutes have reprogrammed non-cardiac cells to serve as healthy replacement cells in damaged heart tissue. The work, which is described in Science, offers rare hope for a mostly hopeless health condition.
Scientists have found a new way to transform human skin cells into heart-like cells in mice by using chemicals instead of genetic modification, in what some experts are calling a major breakthrough.
A new discovery could lead to medicines that repair damage to the heart and nervous system by reprogramming our own cells to play new roles. Previous attempts to reprogram cells introduced new genes to cells to change their behavior. The new method uses chemicals instead, an approach more like the drugs we take today.
In a major breakthrough, Sheng Ding, PhD, and his team at the Gladstone Institutes say they've identified a cocktail of molecules that can coax human skin cells into becoming living, beating heart cells. And what's more, when they implanted them into a damaged mouse heart, they bolstered the existing heart muscle.
Scientists have turned skin into brain and beating heart cells, using a technique similar to the astonishing powers of regeneration of animals like salamanders. They said their revolutionary new method was a significant step towards the day when coronary and Alzheimer’s patients can be treated with their own reprogrammed tissue.
It has long been known that a protein called tau collects in the brain cells of people with Alzheimer’s, but their exact role in the disease was unclear. Now a study in mice has shown how tau interferes with the strengthening of connections between neurons–the key mechanism by which we form memories.
Bats are the only mammals with powered flight, but the evolutionary history of bats wings has been poorly understood. However, new research has provided the first comprehensive look at the genetic origins of their incredible wings.