Heritable diseases—say Huntington’s, sickle cell anemia, or cystic fibrosis—are typically thought of as the result of a certain mutation in one gene. But as Deepak Srivastava and Casey Gifford discovered, sometimes variants of a few genes collectively can cause disease. This, it turns out, is what happened to the Legkiy family. STAT News explains.
Los Angeles Times
Deepak Srivastava has first-hand experience with the power of stem cells. In his own lab, he has studied early heart development and how cells can be reprogrammed to repair damaged heart tissue. He is now president of the Gladstone Institutes and he's about to begin a yearlong term as president of the International Society for Stem Cell Research. He speaks with the Los Angeles Times about what scientists have accomplished with stem cells, and what's coming next.
Experts weigh in after the President’s State of the Union address where he announced the desire to eliminate the HIV epidemic in our country within 10 years.
After years of debating whether hearts have their own stem cells, researchers have concluded they don't. Deepak Srivastava comments on a study that provides evidence suggesting human hearts probably lack stem cells.
Researchers have long used stem cells and fetal matter to test potential HIV/AIDS medications, but the current US administration could put an end to that. Warner Greene speaks to Rolling Stone about how fetal tissue has become a standard tool in modern biomedical research, and how a ban on this tissue could negatively impact science.
The National Institutes of Health (NIH) announced that it will soon embark on a major research effort to find scientific alternatives to human fetal tissue, as a result of the recent directive from the US Department of Health and Human Services for internal NIH scientists to stop procuring human fetal tissue for use in research. Warner Greene tells TIME why the administration's decision has been devastating for his research program.
The Washington Post
The Washington Post reports that the US administration has shut down at least one government-run study that uses fetal tissue implanted into mice even before federal health officials reach a decision on whether to continue such research. Warner Greene, who was a collaborator on that study, describes how this could impact his research for an HIV cure.
Researchers at the National Institutes of Health (NIH) have been ordered not to acquire new fetal tissue for their research since September, as the US administration began an audit of using the tissue funded by the NIH and other agencies. STAT News asks Warner Greene how this will affect his research to examine how HIV reservoirs get established.
The US administration has ordered scientists employed by the National Institutes of Health to stop acquiring new human fetal tissue for experiments, reports ScienceInsider. Warner Greene explains how this has impacted his HIV research and the scientific field.
This article by WIRED magazine describes work at Gladstone by Bruce Conklin, Jennifer Doudna, and Todd McDevitt to establish the epicenter of a whole new field of medicine: genome surgery. Their efforts are perhaps the most concentrated push in a national effort to create the tools and rules necessary for doctors to widely adopt genome editing as part of standard care for the 25 million Americans estimated to be living with one of 6,000 diseases caused by a glitch in their DNA.