About five years ago, two scientists at the Gladstone Institutes — Robert Mahley and Yadong Huang — had seen enough clinical failures in Alzheimer’s drug research to urge a change in strategy. Out of that work, about three years later, came a stealth biotech in South San Francisco called E-Scape Bio. Endpoints tells the story.
Bloomberg Technology looks at a tiny microscope, created by Silicon Valley startup Inscopix, that can capture video of individual neurons firing in the brain. Anatol Kreitzer explains how his Gladstone laboratory uses the microscope to measure and understand how the brain functions during behavior.
The New York Times
In 2001, President George W. Bush issued an executive order banning federal funding for new sources of stem cells developed from preimplantation human embryos. The action stalled research and discouraged scientists.
Five years later, a Kyoto University scientist, Shinya Yamanaka, and his graduate student, Kazutoshi Takahashi, re-energized the field by devising a technique to “reprogram” any adult cell, such as a skin cell, and coax it back to its earliest “pluripotent” stage. From there it can become any type of cell, from a heart muscle cell to a neuron.
Imagine taking a pill to reverse the damage from a heart attack. Scientists at the Gladstone Institutes have made a breakthrough that could bring that kind of treatment a step closer to reality.
Steve Finkbeiner comments in The Scientist on a new study about the importance of donor age when creating induced pluripotent stem cells (iPSCs). He says that "iPSCs and cells differentiated from them will better model aging-related diseases if they retain their epigenetic signature of aging."
Tenaya Therapeutics launched on Wednesday, spinning out of San Francisco-based Gladstone. The company is backed by a $50 million Series A investment from The Column Group and will focus on regenerative medicine and discovering new drugs to treat heart failure.
The Atlantic highlights research by Jorge Palop that showed that enhancing gamma waves in the brain can improve the memories of mice with Alzheimer’s disease. New research builds on Palop's original discovery, suggesting that manipulating brain waves could be a new way to treat Alzheimer's.
Yadong Huang comments in The Scientist on new research that suggests a certain type of brain activity called gamma waves could be leveraged in the fight against Alzheimer's. Huang published related research earlier this year on the role of gamma waves in memory replay and consolidation.
SF Business Times
With a focus on reprogramming cells to regenerate heart muscle, Gladstone Institutes spinout Tenaya Therapeutics Inc. emerged Tuesday with $50 million from The Column Group.
New research has found that infected men could represent a much greater risk to women than mosquitos in regards to Zika infection. That’s because the same weakened immune response in the vagina that makes reproduction possible also leaves women uniquely vulnerable to the virus.