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Recent Publications


"A Hardwired HIV Latency Program."

Cell, 2015.
V.160, i.5


"An Evolutionary Role for HIV Latency in Enhancing Viral Transmission."

Cell, 2015.
V.160, i.5

LabChip2015Jan "Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting. "

Lab on a Chip, 2015


"The case for transmissible antivirals to control population-wide infectious disease. "

Trends in Biotechnology, Cell Press, 2014


"Screening for noise in gene expression identifies drug synergies."

Science, 2014


"Stochastic Fate Selection in HIV-Infected Patients."

Cell, 2013

Rouzine13A"Design Requirements for Interfering Particles To Maintain Coadaptive Stability with HIV-1."

Journal of Virology, 2013

cell2012graphicLSW"An Endogenous Accelerator for Viral Gene Expression Confers a Fitness Advantage"

Cell, 2012

PNAS2012-L"Transcriptional burst frequency and burst size are equally modulated across the human genome."

Proceedings of the National Academy of Sciences, 2012.

The Laboratory for Quantitative and Synthetic Virology

Our lab is interested in understanding the fundamental principles of gene regulatory circuits and how viral 'master circuits' exploit these principles to control virus replication. Ultimately, our goal is to exploit these circuitry principles to engineer the next generation of antiviral therapies.

The lab employs a coupled computational experimental approach that relies on quantitative time-lapse fluorescence microscopy with mathematical modeling to study viral gene expression circuits and expression 'noise' at the single-cell level.

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A 12-hour microscopy movie of human T cells infected with an HIV virus engineered to express red and green fluorescent proteins at different stages of infection. These movies enable us to analyze viral circuitry to identify weak points that can be exploited by novel therapies.


National Institute of General Medical Sciences

HINT (NIAID) HIV Immune Networks Team

Alfred P Sloan Foundation


Bill & Melinda Gates Foundation

W. M. Keck Foundation

Califorani HIV/AIDS Research Program

Weinberger Lab
Gladstone Institute of Virology and Immunology
University of California, San Francisco
1650 Owens Street, San Francisco, CA 94158.
Phone: (415) 734-4857