Related News

September 1, 2016
Cells edited with CRISPRi

CRISPR has enormous potential to cure intractable diseases. At the Gladstone Institutes, scientists are using the technology to advance scientific knowledge and pursue new therapies for heart disease, HIV, dementia, blindness, and more.

August 15, 2016
Dr. Steve Finkbeiner

Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

August 4, 2016
Josh Zimmerman and Todd McDevitt

With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders.

April 28, 2016
Drs. Huang, Ding, Srivastava

In a major breakthrough, Gladstone scientists transformed skin cells into heart cells and brain cells using a combination of chemicals and without adding external genes to the cells.

April 20, 2016
Drs. Bruce Conklin and Nathaniel Huebsch

Gladstone scientists have invented a new way to create micro heart muscle from stem cells using a unique dog bone dish. The three-dimensional tissue is ideal for disease modeling and drug testing.

March 10, 2016
Drs. Conklin and Mandegar

Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have manipulated the genome of induced pluripotent stem cells for the first time using a variation of the CRISPR system.

March 3, 2016
Heart cells created from ieCPCs

Gladstone scientists have discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease.

February 26, 2016
Dr. Shinya Yamanaka

Ten years ago, Shinya Yamanaka revolutionized biological research with his discovery of how to turn ordinary skin cells into stem cells with just four key genes.

February 24, 2016
Dr. Todd McDevitt

Todd McDevitt has rapidly enchanced how Gladstone thinks about bioengineering and stem cell biology.

January 5, 2016
Dr. Sheng Ding

Scientists at the Gladstone Institutes have successfully converted human skin cells into fully-functional pancreatic cells.

September 3, 2015
Dr. Steven Finkbeiner

Advanced imaging and computational technology facilitate the search for cures.

August 26, 2015
Dr. Sheng Ding

Using his unique chemical cocktail, Gladstone’s Sheng Ding has regenerated the cells that die in paralyzing spinal cord injuries.

August 6, 2015

Discovering the earliest signs of heart development brings us one step closer to our ultimate goal: creating a complete blueprint for building new hearts.

July 14, 2015
Dr. Bruce Conklin

The new system could serve as a drug-screening tool to make pregnancies safer.

June 9, 2015
Dr. Steve Finkbeiner

Revelations about a key cellular pathway have important implications for neurodegenerative diseases like ALS and frontotemporal dementia.

May 12, 2015
Dr. Todd McDevitt

The new strategy is more sustainable and less risky than the current standard therapies.

March 12, 2015
Heart tissue from iPS cells

Scientists have discovered why some heart tissue turns into bone, and they may have learned how to stop it.

February 2, 2015

By helping cells switch their type, we may have discovered a new way to repair damaged hearts, and potentially revolutionize the future of medicine.

Roddenberry Center for Stem Cell Biology and Regenerative Medicine

Gladstone strategically built a diverse community of scientific and clinical experts whose mission is to make ground-breaking scientific discoveries and bring these advances to the clinic.

 

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iPSC Discovery

Shinya Yamanaka’s discovery of induced pluripotent stem (iPS) cells in 2006 fundamentally changed biomedical research. He showed that skin cells can be reprogrammed into stem cells that, like embryonic stem cells, can develop into virtually any cell type in the body.

 

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