CRISPR has enormous potential to cure intractable diseases. At the Gladstone Institutes, scientists are using the technology to advance scientific knowledge and pursue new therapies for heart disease, HIV, dementia, blindness, and more.
Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.
With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders.
In a major breakthrough, Gladstone scientists transformed skin cells into heart cells and brain cells using a combination of chemicals and without adding external genes to the cells.
Gladstone scientists have invented a new way to create micro heart muscle from stem cells using a unique dog bone dish. The three-dimensional tissue is ideal for disease modeling and drug testing.
Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have manipulated the genome of induced pluripotent stem cells for the first time using a variation of the CRISPR system.
Gladstone scientists have discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease.
Ten years ago, Shinya Yamanaka revolutionized biological research with his discovery of how to turn ordinary skin cells into stem cells with just four key genes.
Todd McDevitt has rapidly enchanced how Gladstone thinks about bioengineering and stem cell biology.
Scientists at the Gladstone Institutes have successfully converted human skin cells into fully-functional pancreatic cells.
Advanced imaging and computational technology facilitate the search for cures.
Using his unique chemical cocktail, Gladstone’s Sheng Ding has regenerated the cells that die in paralyzing spinal cord injuries.
Discovering the earliest signs of heart development brings us one step closer to our ultimate goal: creating a complete blueprint for building new hearts.
The new system could serve as a drug-screening tool to make pregnancies safer.
Revelations about a key cellular pathway have important implications for neurodegenerative diseases like ALS and frontotemporal dementia.
The new strategy is more sustainable and less risky than the current standard therapies.
Scientists have discovered why some heart tissue turns into bone, and they may have learned how to stop it.
By helping cells switch their type, we may have discovered a new way to repair damaged hearts, and potentially revolutionize the future of medicine.