SAN FRANCISCO, CA—In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
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SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have invented a new way to create three-dimensional human heart tissue from stem cells. The tissue can be used to model disease and test drugs, and it opens the door for a precision medicine approach to treating heart disease.
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have invented a new way to read and interpret the human genome. The computational method, called TargetFinder, can predict where non-coding DNA—the DNA that does not code for proteins—interacts with genes.
SAN FRANCISCO, CA—Scientists have long known that the protein tau is involved in dementia, but how it hinders cognitive function has remained uncertain. In a study published in the journal Neuron, researchers at the Gladstone Institutes reveal how tau disrupts the ability of brain cells to strengthen connections with other brain cells, preventing new memories from forming.
SAN FRANCISCO, CA—Combining the two most powerful biological tools of the 21st century, scientists at the Gladstone Institutes have modified how the genome of induced pluripotent stem cells (iPSCs) is read for the first time using a variation of the CRISPR-Cas9 system.
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered how to make a new type of cell that is in between embryonic stem cells and adult heart cells, and that may hold the key to treating heart disease.
SAN FRANCISCO, CA—Scientists at the Gladstone Institutes have discovered that three transcription factors—proteins that direct gene expression—interact with each other and the genome to influence how a heart forms in an embryo.
SAN FRANCISCO, CA—In a pair of new studies, Gladstone scientists discovered a specific neural circuit that controls walking, and they found that input to this circuit is disrupted in Parkinson’s disease.
SAN FRANCISCO, CA—Study seeks to improve translation of Alzheimer’s disease studies with virtual version of the Morris water maze—the most commonly used memory assessment in mice.